Health-related quality of life in multiple system atrophy
Identifieur interne : 001B25 ( PascalFrancis/Corpus ); précédent : 001B24; suivant : 001B26Health-related quality of life in multiple system atrophy
Auteurs : Anette Schrag ; Felix Geser ; Michaela Stampfer-Kountchev ; Klaus Seppi ; Martin Sawires ; Martin Köllensperger ; Christoph Scherfler ; Niall Quinn ; Maria T. Pellecchia ; Paolo Barone ; Francesca Del Sorbo ; Alberto Albanese ; Karen Ostergaard ; Erik Dupont ; Adriana Cardozo ; Eduardo Tolosa ; Christer F. Nilsson ; Hakan Widner ; Olle Lindvall ; Nir Giladi ; Tanya Gurevich ; Christine Daniels ; Günther Deuschl ; Miguel Coelho ; Cristina Sampaio ; Michael Abele ; Thomas Klockgether ; Nicole Schimke ; Karla M. Eggert ; Wolfgang Oertel ; Ruth Djaldetti ; Carlo Colosimo ; Giuseppe Meco ; Werner Poewe ; Gregor K. WenningSource :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI ≥ 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
| pA |
|
|---|
Format Inist (serveur)
| NO : | PASCAL 06-0352376 INIST |
|---|---|
| ET : | Health-related quality of life in multiple system atrophy |
| AU : | SCHRAG (Anette); GESER (Felix); STAMPFER-KOUNTCHEV (Michaela); SEPPI (Klaus); SAWIRES (Martin); KÖLLENSPERGER (Martin); SCHERFLER (Christoph); QUINN (Niall); PELLECCHIA (Maria T.); BARONE (Paolo); DEL SORBO (Francesca); ALBANESE (Alberto); OSTERGAARD (Karen); DUPONT (Erik); CARDOZO (Adriana); TOLOSA (Eduardo); NILSSON (Christer F.); WIDNER (Hakan); LINDVALL (Olle); GILADI (Nir); GUREVICH (Tanya); DANIELS (Christine); DEUSCHL (Günther); COELHO (Miguel); SAMPAIO (Cristina); ABELE (Michael); KLOCKGETHER (Thomas); SCHIMKE (Nicole); EGGERT (Karla M.); OERTEL (Wolfgang); DJALDETTI (Ruth); COLOSIMO (Carlo); MECO (Giuseppe); POEWE (Werner); WENNING (Gregor K.) |
| AF : | Department of Clinical Neurosciences, Royal Free & University College Medical School/London/Royaume-Uni (1 aut.); Clinical Department of Neurology, Innsbruck Medical University/Autriche (2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 34 aut., 35 aut.); University College London, Institute of Neurology, Queen Square/London/Royaume-Uni (8 aut.); Department of Neurological Sciences, University Federico II/Naples/Italie (9 aut., 10 aut.); Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore/Milano/Italie (11 aut., 12 aut.); Aarhus University Hospital, Department of Neurology/Aarhus/Danemark (13 aut., 14 aut.); Universitat de Barcelona, Hospital Clinic, Department of Neurology/Espagne (15 aut., 16 aut.); Department of Clinical Neuroscience, Division of Neurology, University of Lund/Suède (17 aut., 18 aut., 19 aut.); Tel Aviv Sourasky Medical Center, Movement Disorders Unit, Department of Neurology/Israël (20 aut., 21 aut.); Department of Neurology, Christian-Albrechts University of Kiel/Kiel/Allemagne (22 aut., 23 aut.); Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa/Portugal (24 aut., 25 aut.); University of Bonn, Department of Neurology/Allemagne (26 aut., 27 aut.); Philipps-University Marburg, Department of Neurology/Allemagne (28 aut., 29 aut., 30 aut.); Department of Neurology, Rabin Medical Center/Petach-Tiqva/Israël (31 aut.); University of Roma, "La Sapienza, " Department of Neuroscience/Italie (32 aut., 33 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 6; Pp. 809-815; Bibl. 24 ref. |
| LA : | Anglais |
| EA : | Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI ≥ 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. |
| CC : | 002B17; 002B17F; 002B17G |
| FD : | Système nerveux pathologie; Atrophie multisystématisée; Etat dépressif; Qualité vie; Trouble fonctionnel |
| FG : | Trouble humeur |
| ED : | Nervous system diseases; Multiple system atrophy; Depression; Quality of life; Dysfunction |
| EG : | Mood disorder |
| SD : | Sistema nervioso patología; Atrofia multisistematizada; Estado depresivo; Calidad vida; Trastorno funcional |
| LO : | INIST-20953.354000138863880120 |
| ID : | 06-0352376 |
Links to Exploration step
Pascal:06-0352376Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Health-related quality of life in multiple system atrophy</title><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name><affiliation><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, Royal Free & University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Stampfer Kountchev, Michaela" sort="Stampfer Kountchev, Michaela" uniqKey="Stampfer Kountchev M" first="Michaela" last="Stampfer-Kountchev">Michaela Stampfer-Kountchev</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name><affiliation><inist:fA14 i1="03"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pellecchia, Maria T" sort="Pellecchia, Maria T" uniqKey="Pellecchia M" first="Maria T." last="Pellecchia">Maria T. Pellecchia</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Del Sorbo, Francesca" sort="Del Sorbo, Francesca" uniqKey="Del Sorbo F" first="Francesca" last="Del Sorbo">Francesca Del Sorbo</name><affiliation><inist:fA14 i1="05"><s1>Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore</s1><s2>Milano</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation><inist:fA14 i1="05"><s1>Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore</s1><s2>Milano</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name><affiliation><inist:fA14 i1="06"><s1>Aarhus University Hospital, Department of Neurology</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dupont, Erik" sort="Dupont, Erik" uniqKey="Dupont E" first="Erik" last="Dupont">Erik Dupont</name><affiliation><inist:fA14 i1="06"><s1>Aarhus University Hospital, Department of Neurology</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name><affiliation><inist:fA14 i1="07"><s1>Universitat de Barcelona, Hospital Clinic, Department of Neurology</s1><s3>ESP</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation><inist:fA14 i1="07"><s1>Universitat de Barcelona, Hospital Clinic, Department of Neurology</s1><s3>ESP</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Nilsson, Christer F" sort="Nilsson, Christer F" uniqKey="Nilsson C" first="Christer F." last="Nilsson">Christer F. Nilsson</name><affiliation><inist:fA14 i1="08"><s1>Department of Clinical Neuroscience, Division of Neurology, University of Lund</s1><s3>SWE</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Widner, Hakan" sort="Widner, Hakan" uniqKey="Widner H" first="Hakan" last="Widner">Hakan Widner</name><affiliation><inist:fA14 i1="08"><s1>Department of Clinical Neuroscience, Division of Neurology, University of Lund</s1><s3>SWE</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name><affiliation><inist:fA14 i1="08"><s1>Department of Clinical Neuroscience, Division of Neurology, University of Lund</s1><s3>SWE</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><inist:fA14 i1="09"><s1>Tel Aviv Sourasky Medical Center, Movement Disorders Unit, Department of Neurology</s1><s3>ISR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name><affiliation><inist:fA14 i1="09"><s1>Tel Aviv Sourasky Medical Center, Movement Disorders Unit, Department of Neurology</s1><s3>ISR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Christian-Albrechts University of Kiel</s1><s2>Kiel</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Christian-Albrechts University of Kiel</s1><s2>Kiel</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Coelho, Miguel" sort="Coelho, Miguel" uniqKey="Coelho M" first="Miguel" last="Coelho">Miguel Coelho</name><affiliation><inist:fA14 i1="11"><s1>Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa</s1><s3>PRT</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name><affiliation><inist:fA14 i1="11"><s1>Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa</s1><s3>PRT</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name><affiliation><inist:fA14 i1="12"><s1>University of Bonn, Department of Neurology</s1><s3>DEU</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation><inist:fA14 i1="12"><s1>University of Bonn, Department of Neurology</s1><s3>DEU</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name><affiliation><inist:fA14 i1="13"><s1>Philipps-University Marburg, Department of Neurology</s1><s3>DEU</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><affiliation><inist:fA14 i1="13"><s1>Philipps-University Marburg, Department of Neurology</s1><s3>DEU</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name><affiliation><inist:fA14 i1="13"><s1>Philipps-University Marburg, Department of Neurology</s1><s3>DEU</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Djaldetti, Ruth" sort="Djaldetti, Ruth" uniqKey="Djaldetti R" first="Ruth" last="Djaldetti">Ruth Djaldetti</name><affiliation><inist:fA14 i1="14"><s1>Department of Neurology, Rabin Medical Center</s1><s2>Petach-Tiqva</s2><s3>ISR</s3><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation><inist:fA14 i1="15"><s1>University of Roma, "La Sapienza, " Department of Neuroscience</s1><s3>ITA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation><inist:fA14 i1="15"><s1>University of Roma, "La Sapienza, " Department of Neuroscience</s1><s3>ITA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0352376</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0352376 INIST</idno><idno type="RBID">Pascal:06-0352376</idno><idno type="wicri:Area/PascalFrancis/Corpus">001B25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Health-related quality of life in multiple system atrophy</title><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name><affiliation><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, Royal Free & University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Stampfer Kountchev, Michaela" sort="Stampfer Kountchev, Michaela" uniqKey="Stampfer Kountchev M" first="Michaela" last="Stampfer-Kountchev">Michaela Stampfer-Kountchev</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name><affiliation><inist:fA14 i1="03"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pellecchia, Maria T" sort="Pellecchia, Maria T" uniqKey="Pellecchia M" first="Maria T." last="Pellecchia">Maria T. Pellecchia</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Del Sorbo, Francesca" sort="Del Sorbo, Francesca" uniqKey="Del Sorbo F" first="Francesca" last="Del Sorbo">Francesca Del Sorbo</name><affiliation><inist:fA14 i1="05"><s1>Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore</s1><s2>Milano</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation><inist:fA14 i1="05"><s1>Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore</s1><s2>Milano</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name><affiliation><inist:fA14 i1="06"><s1>Aarhus University Hospital, Department of Neurology</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dupont, Erik" sort="Dupont, Erik" uniqKey="Dupont E" first="Erik" last="Dupont">Erik Dupont</name><affiliation><inist:fA14 i1="06"><s1>Aarhus University Hospital, Department of Neurology</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name><affiliation><inist:fA14 i1="07"><s1>Universitat de Barcelona, Hospital Clinic, Department of Neurology</s1><s3>ESP</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation><inist:fA14 i1="07"><s1>Universitat de Barcelona, Hospital Clinic, Department of Neurology</s1><s3>ESP</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Nilsson, Christer F" sort="Nilsson, Christer F" uniqKey="Nilsson C" first="Christer F." last="Nilsson">Christer F. Nilsson</name><affiliation><inist:fA14 i1="08"><s1>Department of Clinical Neuroscience, Division of Neurology, University of Lund</s1><s3>SWE</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Widner, Hakan" sort="Widner, Hakan" uniqKey="Widner H" first="Hakan" last="Widner">Hakan Widner</name><affiliation><inist:fA14 i1="08"><s1>Department of Clinical Neuroscience, Division of Neurology, University of Lund</s1><s3>SWE</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name><affiliation><inist:fA14 i1="08"><s1>Department of Clinical Neuroscience, Division of Neurology, University of Lund</s1><s3>SWE</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><inist:fA14 i1="09"><s1>Tel Aviv Sourasky Medical Center, Movement Disorders Unit, Department of Neurology</s1><s3>ISR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gurevich, Tanya" sort="Gurevich, Tanya" uniqKey="Gurevich T" first="Tanya" last="Gurevich">Tanya Gurevich</name><affiliation><inist:fA14 i1="09"><s1>Tel Aviv Sourasky Medical Center, Movement Disorders Unit, Department of Neurology</s1><s3>ISR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Christian-Albrechts University of Kiel</s1><s2>Kiel</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Christian-Albrechts University of Kiel</s1><s2>Kiel</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Coelho, Miguel" sort="Coelho, Miguel" uniqKey="Coelho M" first="Miguel" last="Coelho">Miguel Coelho</name><affiliation><inist:fA14 i1="11"><s1>Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa</s1><s3>PRT</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name><affiliation><inist:fA14 i1="11"><s1>Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa</s1><s3>PRT</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name><affiliation><inist:fA14 i1="12"><s1>University of Bonn, Department of Neurology</s1><s3>DEU</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation><inist:fA14 i1="12"><s1>University of Bonn, Department of Neurology</s1><s3>DEU</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name><affiliation><inist:fA14 i1="13"><s1>Philipps-University Marburg, Department of Neurology</s1><s3>DEU</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><affiliation><inist:fA14 i1="13"><s1>Philipps-University Marburg, Department of Neurology</s1><s3>DEU</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name><affiliation><inist:fA14 i1="13"><s1>Philipps-University Marburg, Department of Neurology</s1><s3>DEU</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Djaldetti, Ruth" sort="Djaldetti, Ruth" uniqKey="Djaldetti R" first="Ruth" last="Djaldetti">Ruth Djaldetti</name><affiliation><inist:fA14 i1="14"><s1>Department of Neurology, Rabin Medical Center</s1><s2>Petach-Tiqva</s2><s3>ISR</s3><sZ>31 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation><inist:fA14 i1="15"><s1>University of Roma, "La Sapienza, " Department of Neuroscience</s1><s3>ITA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation><inist:fA14 i1="15"><s1>University of Roma, "La Sapienza, " Department of Neuroscience</s1><s3>ITA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation><inist:fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Depression</term><term>Dysfunction</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Quality of life</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Atrophie multisystématisée</term><term>Etat dépressif</term><term>Qualité vie</term><term>Trouble fonctionnel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI ≥ 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>21</s2></fA05><fA06><s2>6</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Health-related quality of life in multiple system atrophy</s1></fA08><fA11 i1="01" i2="1"><s1>SCHRAG (Anette)</s1></fA11><fA11 i1="02" i2="1"><s1>GESER (Felix)</s1></fA11><fA11 i1="03" i2="1"><s1>STAMPFER-KOUNTCHEV (Michaela)</s1></fA11><fA11 i1="04" i2="1"><s1>SEPPI (Klaus)</s1></fA11><fA11 i1="05" i2="1"><s1>SAWIRES (Martin)</s1></fA11><fA11 i1="06" i2="1"><s1>KÖLLENSPERGER (Martin)</s1></fA11><fA11 i1="07" i2="1"><s1>SCHERFLER (Christoph)</s1></fA11><fA11 i1="08" i2="1"><s1>QUINN (Niall)</s1></fA11><fA11 i1="09" i2="1"><s1>PELLECCHIA (Maria T.)</s1></fA11><fA11 i1="10" i2="1"><s1>BARONE (Paolo)</s1></fA11><fA11 i1="11" i2="1"><s1>DEL SORBO (Francesca)</s1></fA11><fA11 i1="12" i2="1"><s1>ALBANESE (Alberto)</s1></fA11><fA11 i1="13" i2="1"><s1>OSTERGAARD (Karen)</s1></fA11><fA11 i1="14" i2="1"><s1>DUPONT (Erik)</s1></fA11><fA11 i1="15" i2="1"><s1>CARDOZO (Adriana)</s1></fA11><fA11 i1="16" i2="1"><s1>TOLOSA (Eduardo)</s1></fA11><fA11 i1="17" i2="1"><s1>NILSSON (Christer F.)</s1></fA11><fA11 i1="18" i2="1"><s1>WIDNER (Hakan)</s1></fA11><fA11 i1="19" i2="1"><s1>LINDVALL (Olle)</s1></fA11><fA11 i1="20" i2="1"><s1>GILADI (Nir)</s1></fA11><fA11 i1="21" i2="1"><s1>GUREVICH (Tanya)</s1></fA11><fA11 i1="22" i2="1"><s1>DANIELS (Christine)</s1></fA11><fA11 i1="23" i2="1"><s1>DEUSCHL (Günther)</s1></fA11><fA11 i1="24" i2="1"><s1>COELHO (Miguel)</s1></fA11><fA11 i1="25" i2="1"><s1>SAMPAIO (Cristina)</s1></fA11><fA11 i1="26" i2="1"><s1>ABELE (Michael)</s1></fA11><fA11 i1="27" i2="1"><s1>KLOCKGETHER (Thomas)</s1></fA11><fA11 i1="28" i2="1"><s1>SCHIMKE (Nicole)</s1></fA11><fA11 i1="29" i2="1"><s1>EGGERT (Karla M.)</s1></fA11><fA11 i1="30" i2="1"><s1>OERTEL (Wolfgang)</s1></fA11><fA11 i1="31" i2="1"><s1>DJALDETTI (Ruth)</s1></fA11><fA11 i1="32" i2="1"><s1>COLOSIMO (Carlo)</s1></fA11><fA11 i1="33" i2="1"><s1>MECO (Giuseppe)</s1></fA11><fA11 i1="34" i2="1"><s1>POEWE (Werner)</s1></fA11><fA11 i1="35" i2="1"><s1>WENNING (Gregor K.)</s1></fA11><fA14 i1="01"><s1>Department of Clinical Neurosciences, Royal Free & University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></fA14><fA14 i1="03"><s1>University College London, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>8 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurological Sciences, University Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="05"><s1>Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore</s1><s2>Milano</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="06"><s1>Aarhus University Hospital, Department of Neurology</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="07"><s1>Universitat de Barcelona, Hospital Clinic, Department of Neurology</s1><s3>ESP</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Clinical Neuroscience, Division of Neurology, University of Lund</s1><s3>SWE</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="09"><s1>Tel Aviv Sourasky Medical Center, Movement Disorders Unit, Department of Neurology</s1><s3>ISR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Neurology, Christian-Albrechts University of Kiel</s1><s2>Kiel</s2><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="11"><s1>Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa</s1><s3>PRT</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="12"><s1>University of Bonn, Department of Neurology</s1><s3>DEU</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></fA14><fA14 i1="13"><s1>Philipps-University Marburg, Department of Neurology</s1><s3>DEU</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></fA14><fA14 i1="14"><s1>Department of Neurology, Rabin Medical Center</s1><s2>Petach-Tiqva</s2><s3>ISR</s3><sZ>31 aut.</sZ></fA14><fA14 i1="15"><s1>University of Roma, "La Sapienza, " Department of Neuroscience</s1><s3>ITA</s3><sZ>32 aut.</sZ><sZ>33 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>European MSA-Study Group</s1><s3>INC</s3></fA17><fA20><s1>809-815</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000138863880120</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0352376</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI ≥ 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17F</s0></fC02><fC02 i1="03" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Multiple system atrophy</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Etat dépressif</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Depression</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Estado depresivo</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Qualité vie</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Quality of life</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Calidad vida</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Trouble fonctionnel</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Dysfunction</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Trastorno funcional</s0><s5>10</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Trouble humeur</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Mood disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Trastorno humor</s0><s5>37</s5></fC07><fN21><s1>233</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 06-0352376 INIST</NO><ET>Health-related quality of life in multiple system atrophy</ET><AU>SCHRAG (Anette); GESER (Felix); STAMPFER-KOUNTCHEV (Michaela); SEPPI (Klaus); SAWIRES (Martin); KÖLLENSPERGER (Martin); SCHERFLER (Christoph); QUINN (Niall); PELLECCHIA (Maria T.); BARONE (Paolo); DEL SORBO (Francesca); ALBANESE (Alberto); OSTERGAARD (Karen); DUPONT (Erik); CARDOZO (Adriana); TOLOSA (Eduardo); NILSSON (Christer F.); WIDNER (Hakan); LINDVALL (Olle); GILADI (Nir); GUREVICH (Tanya); DANIELS (Christine); DEUSCHL (Günther); COELHO (Miguel); SAMPAIO (Cristina); ABELE (Michael); KLOCKGETHER (Thomas); SCHIMKE (Nicole); EGGERT (Karla M.); OERTEL (Wolfgang); DJALDETTI (Ruth); COLOSIMO (Carlo); MECO (Giuseppe); POEWE (Werner); WENNING (Gregor K.)</AU><AF>Department of Clinical Neurosciences, Royal Free & University College Medical School/London/Royaume-Uni (1 aut.); Clinical Department of Neurology, Innsbruck Medical University/Autriche (2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 34 aut., 35 aut.); University College London, Institute of Neurology, Queen Square/London/Royaume-Uni (8 aut.); Department of Neurological Sciences, University Federico II/Naples/Italie (9 aut., 10 aut.); Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore/Milano/Italie (11 aut., 12 aut.); Aarhus University Hospital, Department of Neurology/Aarhus/Danemark (13 aut., 14 aut.); Universitat de Barcelona, Hospital Clinic, Department of Neurology/Espagne (15 aut., 16 aut.); Department of Clinical Neuroscience, Division of Neurology, University of Lund/Suède (17 aut., 18 aut., 19 aut.); Tel Aviv Sourasky Medical Center, Movement Disorders Unit, Department of Neurology/Israël (20 aut., 21 aut.); Department of Neurology, Christian-Albrechts University of Kiel/Kiel/Allemagne (22 aut., 23 aut.); Faculdade de Medicina de Lisboa, Hopital Santa Maria, Centro de Neurosciencias de Lisboa/Portugal (24 aut., 25 aut.); University of Bonn, Department of Neurology/Allemagne (26 aut., 27 aut.); Philipps-University Marburg, Department of Neurology/Allemagne (28 aut., 29 aut., 30 aut.); Department of Neurology, Rabin Medical Center/Petach-Tiqva/Israël (31 aut.); University of Roma, "La Sapienza, " Department of Neuroscience/Italie (32 aut., 33 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 6; Pp. 809-815; Bibl. 24 ref.</SO><LA>Anglais</LA><EA>Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI ≥ 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.</EA><CC>002B17; 002B17F; 002B17G</CC><FD>Système nerveux pathologie; Atrophie multisystématisée; Etat dépressif; Qualité vie; Trouble fonctionnel</FD><FG>Trouble humeur</FG><ED>Nervous system diseases; Multiple system atrophy; Depression; Quality of life; Dysfunction</ED><EG>Mood disorder</EG><SD>Sistema nervioso patología; Atrofia multisistematizada; Estado depresivo; Calidad vida; Trastorno funcional</SD><LO>INIST-20953.354000138863880120</LO><ID>06-0352376</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B25 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001B25 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PascalFrancis
|étape= Corpus
|type= RBID
|clé= Pascal:06-0352376
|texte= Health-related quality of life in multiple system atrophy
}}
| This area was generated with Dilib version V0.6.23. |  |