MovDisordV3, PascalFrancis, Corpus, bibRecord, 001B16

Does seasonal variation affect hallucinations in PD? A longitudinal study

Identifieur interne : 001B16 ( PascalFrancis/Corpus ); précédent : 001B15; suivant : 001B17

Does seasonal variation affect hallucinations in PD? A longitudinal study

Auteurs : Christopher G. Goetz ; John Michael Li ; Joanne Wuu ; Sue Leurgans

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0352385

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Hallucination, Parkinson maladie, Variation saisonnière, Chronobiologie.

English descriptors

KwdEn :
- Chronobiology, Hallucination, Nervous system diseases, Parkinson disease, Seasonal variation.

Abstract

The objective of this study was to examine the chronobiology of visual hallucinations in Parkinson's disease (PD) patients to test whether hallucinations are more severe during darker months (winter) than summer months. We extracted longitudinal data on the UPDRS Thought Disorder (TD) score, taken as part of regular patient management on sequential visits through a 1-year cycle in hallucinating PD patients. To reduce the confounding effects of medication adjustments, analysis was restricted to patients with a baseline evaluation that did not involve a medication change. The primary outcome was the seasonal change in hallucination severity, defined as a change in TD score or neuroleptic use. Using Wilcoxon rank-sum tests, we compared the exacerbation of hallucination by season, focusing on winter (December through February) versus summer (June through August). A total of 51 hallucinating patients met entry criteria, and their longitudinal data were analyzed. There was no difference in hallucination severity with changing season; the level of wintertime exacerbation was no greater than summertime exacerbation (P = 0.42). Although hallucinations frequently develop in dimmed environments and evening hours, the darkness of wintertime does not exacerbate hallucinations in PD subjects on stable medications. Because we found no evidence of seasonal variations, we cannot recommend phototherapy or other strategies affecting chronobiological systems as research priorities to treat PD hallucinations.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 06-0352385 INIST
ET :	Does seasonal variation affect hallucinations in PD? A longitudinal study
AU :	GOETZ (Christopher G.); LI (John Michael); WUU (Joanne); LEURGANS (Sue)
AF :	Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 6; Pp. 863-865; Bibl. 12 ref.
LA :	Anglais
EA :	The objective of this study was to examine the chronobiology of visual hallucinations in Parkinson's disease (PD) patients to test whether hallucinations are more severe during darker months (winter) than summer months. We extracted longitudinal data on the UPDRS Thought Disorder (TD) score, taken as part of regular patient management on sequential visits through a 1-year cycle in hallucinating PD patients. To reduce the confounding effects of medication adjustments, analysis was restricted to patients with a baseline evaluation that did not involve a medication change. The primary outcome was the seasonal change in hallucination severity, defined as a change in TD score or neuroleptic use. Using Wilcoxon rank-sum tests, we compared the exacerbation of hallucination by season, focusing on winter (December through February) versus summer (June through August). A total of 51 hallucinating patients met entry criteria, and their longitudinal data were analyzed. There was no difference in hallucination severity with changing season; the level of wintertime exacerbation was no greater than summertime exacerbation (P = 0.42). Although hallucinations frequently develop in dimmed environments and evening hours, the darkness of wintertime does not exacerbate hallucinations in PD subjects on stable medications. Because we found no evidence of seasonal variations, we cannot recommend phototherapy or other strategies affecting chronobiological systems as research priorities to treat PD hallucinations.
CC :	002B17; 002B17F; 002B24B07
FD :	Système nerveux pathologie; Hallucination; Parkinson maladie; Variation saisonnière; Chronobiologie
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Hallucination; Parkinson disease; Seasonal variation; Chronobiology
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Alucinación; Parkinson enfermedad; Variación estacional; Cronobiología
LO :	INIST-20953.354000138863880210
ID :	06-0352385

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Pascal:06-0352385

Le document en format XML

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<front><div type="abstract" xml:lang="en">The objective of this study was to examine the chronobiology of visual hallucinations in Parkinson's disease (PD) patients to test whether hallucinations are more severe during darker months (winter) than summer months. We extracted longitudinal data on the UPDRS Thought Disorder (TD) score, taken as part of regular patient management on sequential visits through a 1-year cycle in hallucinating PD patients. To reduce the confounding effects of medication adjustments, analysis was restricted to patients with a baseline evaluation that did not involve a medication change. The primary outcome was the seasonal change in hallucination severity, defined as a change in TD score or neuroleptic use. Using Wilcoxon rank-sum tests, we compared the exacerbation of hallucination by season, focusing on winter (December through February) versus summer (June through August). A total of 51 hallucinating patients met entry criteria, and their longitudinal data were analyzed. There was no difference in hallucination severity with changing season; the level of wintertime exacerbation was no greater than summertime exacerbation (P = 0.42). Although hallucinations frequently develop in dimmed environments and evening hours, the darkness of wintertime does not exacerbate hallucinations in PD subjects on stable medications. Because we found no evidence of seasonal variations, we cannot recommend phototherapy or other strategies affecting chronobiological systems as research priorities to treat PD hallucinations.</div>
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<ET>Does seasonal variation affect hallucinations in PD? A longitudinal study</ET>
<AU>GOETZ (Christopher G.); LI (John Michael); WUU (Joanne); LEURGANS (Sue)</AU>
<AF>Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 6; Pp. 863-865; Bibl. 12 ref.</SO>
<LA>Anglais</LA>
<EA>The objective of this study was to examine the chronobiology of visual hallucinations in Parkinson's disease (PD) patients to test whether hallucinations are more severe during darker months (winter) than summer months. We extracted longitudinal data on the UPDRS Thought Disorder (TD) score, taken as part of regular patient management on sequential visits through a 1-year cycle in hallucinating PD patients. To reduce the confounding effects of medication adjustments, analysis was restricted to patients with a baseline evaluation that did not involve a medication change. The primary outcome was the seasonal change in hallucination severity, defined as a change in TD score or neuroleptic use. Using Wilcoxon rank-sum tests, we compared the exacerbation of hallucination by season, focusing on winter (December through February) versus summer (June through August). A total of 51 hallucinating patients met entry criteria, and their longitudinal data were analyzed. There was no difference in hallucination severity with changing season; the level of wintertime exacerbation was no greater than summertime exacerbation (P = 0.42). Although hallucinations frequently develop in dimmed environments and evening hours, the darkness of wintertime does not exacerbate hallucinations in PD subjects on stable medications. Because we found no evidence of seasonal variations, we cannot recommend phototherapy or other strategies affecting chronobiological systems as research priorities to treat PD hallucinations.</EA>
<CC>002B17; 002B17F; 002B24B07</CC>
<FD>Système nerveux pathologie; Hallucination; Parkinson maladie; Variation saisonnière; Chronobiologie</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Hallucination; Parkinson disease; Seasonal variation; Chronobiology</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Alucinación; Parkinson enfermedad; Variación estacional; Cronobiología</SD>
<LO>INIST-20953.354000138863880210</LO>
<ID>06-0352385</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Does seasonal variation affect hallucinations in PD? A longitudinal study

Does seasonal variation affect hallucinations in PD? A longitudinal study

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