MovDisordV3, PascalFrancis, Corpus, bibRecord, 001A50

Relative risk of spread of symptoms among the focal onset primary dystonias

Identifieur interne : 001A50 ( PascalFrancis/Corpus ); précédent : 001A49; suivant : 001A51

Relative risk of spread of symptoms among the focal onset primary dystonias

Auteurs : Elliott M. Weiss ; Tamara Hershey ; Morvarid Karimi ; Brad Racette ; Samer D. Tabbal ; Jonathan W. Mink ; Randal C. Paniello ; Joel S. Perlmutter

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0435088

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Dystonie, Blépharospasme, Facteur risque, Pronostic.

English descriptors

KwdEn :
- Blepharospasm, Dystonia, Nervous system diseases, Prognosis, Risk factor.

Abstract

Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`08`	`1`		`@1 PERLMUTTER (Joel S.)`
A14	`01`			`@1 Department of Neurology, Washington University School of Medicine @2 St. Louis, Missouri @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 8 aut.`
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A14	`03`			`@1 Department of Radiology, Washington University School of Medicine @2 St. Louis, Missouri @3 USA @Z 2 aut. @Z 8 aut.`
A14	`04`			`@1 Department of Neurology, University of Rochester Medical Center @2 Rochester, New York @3 USA @Z 6 aut.`
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A14	`06`			`@1 Department of Pediatrics, University of Rochester Medical Center @2 Rochester, New York @3 USA @Z 6 aut.`
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C01	`01`		`ENG`	@0 Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias.
C02	`01`	`X`		`@0 002B17`
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C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
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C03	`02`	`X`	`SPA`	`@0 Distonía @5 02`
C03	`03`	`X`	`FRE`	`@0 Blépharospasme @5 03`
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C03	`05`	`X`	`ENG`	`@0 Prognosis @5 10`
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C07	`01`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 37`
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C07	`02`	`X`	`FRE`	`@0 Mouvement involontaire @5 38`
C07	`02`	`X`	`ENG`	`@0 Involuntary movement @5 38`
C07	`02`	`X`	`SPA`	`@0 Movimiento involuntario @5 38`
C07	`03`	`X`	`FRE`	`@0 Muscle strié pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Striated muscle disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Músculo estriado patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Trouble neurologique @5 40`
C07	`04`	`X`	`ENG`	`@0 Neurological disorder @5 40`
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C07	`07`	`X`	`SPA`	`@0 Encéfalo patología @5 43`
C07	`08`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 44`
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N21				`@1 289`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 06-0435088 INIST
ET :	Relative risk of spread of symptoms among the focal onset primary dystonias
AU :	WEISS (Elliott M.); HERSHEY (Tamara); KARIMI (Morvarid); RACETTE (Brad); TABBAL (Samer D.); MINK (Jonathan W.); PANIELLO (Randal C.); PERLMUTTER (Joel S.)
AF :	Department of Neurology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut.); Department of Psychiatry, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut.); Department of Radiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut., 8 aut.); Department of Neurology, University of Rochester Medical Center/Rochester, New York/Etats-Unis (6 aut.); Department of Neurobiology and Anatomy, University of Rochester Medical Center/Rochester, New York/Etats-Unis (6 aut.); Department of Pediatrics, University of Rochester Medical Center/Rochester, New York/Etats-Unis (6 aut.); Department of Otolaryngology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (7 aut.); Department of Anatomy and Neurobiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (8 aut.); Program of Physical Therapy, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 8; Pp. 1175-1181; Bibl. 29 ref.
LA :	Anglais
EA :	Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias.
CC :	002B17; 002B17H; 002B17A01
FD :	Système nerveux pathologie; Dystonie; Blépharospasme; Facteur risque; Pronostic
FG :	Extrapyramidal syndrome; Mouvement involontaire; Muscle strié pathologie; Trouble neurologique; Oeil pathologie; Paupière pathologie; Encéphale pathologie; Système nerveux central pathologie
ED :	Nervous system diseases; Dystonia; Blepharospasm; Risk factor; Prognosis
EG :	Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Eye disease; Eyelid disease; Cerebral disorder; Central nervous system disease
SD :	Sistema nervioso patología; Distonía; Blefaroespasmo; Factor riesgo; Pronóstico
LO :	INIST-20953.354000142193570190
ID :	06-0435088

Links to Exploration step

Pascal:06-0435088

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Relative risk of spread of symptoms among the focal onset primary dystonias</title>
<author><name sortKey="Weiss, Elliott M" sort="Weiss, Elliott M" uniqKey="Weiss E" first="Elliott M." last="Weiss">Elliott M. Weiss</name>
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<author><name sortKey="Hershey, Tamara" sort="Hershey, Tamara" uniqKey="Hershey T" first="Tamara" last="Hershey">Tamara Hershey</name>
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<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry, Washington University School of Medicine</s1>
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<s2>St. Louis, Missouri</s2>
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<author><name sortKey="Karimi, Morvarid" sort="Karimi, Morvarid" uniqKey="Karimi M" first="Morvarid" last="Karimi">Morvarid Karimi</name>
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<author><name sortKey="Racette, Brad" sort="Racette, Brad" uniqKey="Racette B" first="Brad" last="Racette">Brad Racette</name>
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<author><name sortKey="Tabbal, Samer D" sort="Tabbal, Samer D" uniqKey="Tabbal S" first="Samer D." last="Tabbal">Samer D. Tabbal</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
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<author><name sortKey="Mink, Jonathan W" sort="Mink, Jonathan W" uniqKey="Mink J" first="Jonathan W." last="Mink">Jonathan W. Mink</name>
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<s2>Rochester, New York</s2>
<s3>USA</s3>
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</affiliation>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurobiology and Anatomy, University of Rochester Medical Center</s1>
<s2>Rochester, New York</s2>
<s3>USA</s3>
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</inist:fA14>
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<affiliation><inist:fA14 i1="06"><s1>Department of Pediatrics, University of Rochester Medical Center</s1>
<s2>Rochester, New York</s2>
<s3>USA</s3>
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</inist:fA14>
</affiliation>
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<author><name sortKey="Paniello, Randal C" sort="Paniello, Randal C" uniqKey="Paniello R" first="Randal C." last="Paniello">Randal C. Paniello</name>
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<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name>
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<s2>St. Louis, Missouri</s2>
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<sZ>1 aut.</sZ>
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<sZ>5 aut.</sZ>
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<affiliation><inist:fA14 i1="03"><s1>Department of Radiology, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="08"><s1>Department of Anatomy and Neurobiology, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="09"><s1>Program of Physical Therapy, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
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<sZ>8 aut.</sZ>
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</author>
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<series><title level="j" type="main">Movement disorders</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blepharospasm</term>
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<term>Nervous system diseases</term>
<term>Prognosis</term>
<term>Risk factor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Dystonie</term>
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<term>Facteur risque</term>
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<front><div type="abstract" xml:lang="en">Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias.</div>
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<fA11 i1="01" i2="1"><s1>WEISS (Elliott M.)</s1>
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<fA11 i1="05" i2="1"><s1>TABBAL (Samer D.)</s1>
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<sZ>2 aut.</sZ>
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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="02"><s1>Department of Psychiatry, Washington University School of Medicine</s1>
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<fA14 i1="03"><s1>Department of Radiology, Washington University School of Medicine</s1>
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<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="04"><s1>Department of Neurology, University of Rochester Medical Center</s1>
<s2>Rochester, New York</s2>
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<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurobiology and Anatomy, University of Rochester Medical Center</s1>
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<sZ>6 aut.</sZ>
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<fA14 i1="06"><s1>Department of Pediatrics, University of Rochester Medical Center</s1>
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<sZ>6 aut.</sZ>
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<fA14 i1="07"><s1>Department of Otolaryngology, Washington University School of Medicine</s1>
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<sZ>7 aut.</sZ>
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<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Program of Physical Therapy, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
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<fC03 i1="03" i2="X" l="SPA"><s0>Blefaroespasmo</s0>
<s5>03</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Facteur risque</s0>
<s5>09</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Risk factor</s0>
<s5>09</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Paupière pathologie</s0>
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<fC07 i1="06" i2="X" l="ENG"><s0>Eyelid disease</s0>
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<fC07 i1="06" i2="X" l="SPA"><s0>Párpado patología</s0>
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<fC07 i1="07" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
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<fC07 i1="07" i2="X" l="ENG"><s0>Cerebral disorder</s0>
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<fC07 i1="07" i2="X" l="SPA"><s0>Encéfalo patología</s0>
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<ET>Relative risk of spread of symptoms among the focal onset primary dystonias</ET>
<AU>WEISS (Elliott M.); HERSHEY (Tamara); KARIMI (Morvarid); RACETTE (Brad); TABBAL (Samer D.); MINK (Jonathan W.); PANIELLO (Randal C.); PERLMUTTER (Joel S.)</AU>
<AF>Department of Neurology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut.); Department of Psychiatry, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut.); Department of Radiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut., 8 aut.); Department of Neurology, University of Rochester Medical Center/Rochester, New York/Etats-Unis (6 aut.); Department of Neurobiology and Anatomy, University of Rochester Medical Center/Rochester, New York/Etats-Unis (6 aut.); Department of Pediatrics, University of Rochester Medical Center/Rochester, New York/Etats-Unis (6 aut.); Department of Otolaryngology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (7 aut.); Department of Anatomy and Neurobiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (8 aut.); Program of Physical Therapy, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 8; Pp. 1175-1181; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of spread by site of onset of dystonia has not been well characterized. We retrospectively identified 602 patients with PTD out of 1,500 dystonia patients in our electronic database and extracted age at onset, site of onset, family history, and spread. Survival analyses were performed for groups based on site of onset, and hazard ratios compared relative risk of spread across groups. Patients with adult-onset blepharospasm were more likely to spread (31% past the head) than those with dystonia starting in the neck (9%), larynx (12%), or upper extremities (16%). Hazard ratios proved that the blepharospasm group had the greatest relative risk of spread. The rate of spread after onset varied significantly between the different groups. Most spread occurred in the first 1 to 2 years after onset of blepharospasm, whereas the risk of spread was relatively constant over time in cervical and laryngeal dystonia. Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias.</EA>
<CC>002B17; 002B17H; 002B17A01</CC>
<FD>Système nerveux pathologie; Dystonie; Blépharospasme; Facteur risque; Pronostic</FD>
<FG>Extrapyramidal syndrome; Mouvement involontaire; Muscle strié pathologie; Trouble neurologique; Oeil pathologie; Paupière pathologie; Encéphale pathologie; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Dystonia; Blepharospasm; Risk factor; Prognosis</ED>
<EG>Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Eye disease; Eyelid disease; Cerebral disorder; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Distonía; Blefaroespasmo; Factor riesgo; Pronóstico</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Relative risk of spread of symptoms among the focal onset primary dystonias

Relative risk of spread of symptoms among the focal onset primary dystonias

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