MovDisordV3, PascalFrancis, Corpus, bibRecord, 001A00

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

Identifieur interne : 001A00 ( PascalFrancis/Corpus ); précédent : 001999; suivant : 001A01

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

Auteurs : Robert Iansek ; Frances Huxham ; Jennifer Mcginley

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0518096

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Congélation, Noyau gris central.

English descriptors

KwdEn :
- Basal ganglion, Freezing, Nervous system diseases, Parkinson disease.

Abstract

Festination and freezing of gait (FOG) are poorly understood gait disorders that cause disability and falls in people with Parkinson disease (PD). In PD, basal ganglia malfunction leads to motor set deficits (hypokinesia), while altered motor cue production leads to a sequence effect, whereby movements becomes progressively smaller as in festination. We suggest both factors may contribute to FOG. Disturbance of set maintenance by the basal ganglia in PD has previously been examined in gait, but limited systematic evaluation of the sequence effect exists. In this study, we investigated the step-to-step amplitude relationship in 10 PD subjects with clinical evidence of festination and FOG. Four conditions were examined: off levodopa, ojfwith attentional strategies, off with visual cues, and on levodopa. Participants demonstrated a sequence effect (F = 6.24; P = 0.001), which was reversed only by use of visual cues. In contrast, medication, attentional strategies, and visual cues all improved hypokinesia. Variability was marked both within and between participants in all conditions. The variability of FOG is suggested to relate to a combination of factors, including the sequence effect and its variability, as well as the severity of hypokinesia and its response to medications.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 06-0518096 INIST
ET :	The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?
AU :	IANSEK (Robert); HUXHAM (Frances); MCGINLEY (Jennifer)
AF :	Geriatric Research Unit, Kingston Centre Southern Health/Melbourne/Australie (1 aut., 2 aut., 3 aut.); MONARC, Monash University/Melbourne/Australie (1 aut., 2 aut.); Murdoch Children's Research Institute/Melbourne/Australie (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 9; Pp. 1419-1424; Bibl. 26 ref.
LA :	Anglais
EA :	Festination and freezing of gait (FOG) are poorly understood gait disorders that cause disability and falls in people with Parkinson disease (PD). In PD, basal ganglia malfunction leads to motor set deficits (hypokinesia), while altered motor cue production leads to a sequence effect, whereby movements becomes progressively smaller as in festination. We suggest both factors may contribute to FOG. Disturbance of set maintenance by the basal ganglia in PD has previously been examined in gait, but limited systematic evaluation of the sequence effect exists. In this study, we investigated the step-to-step amplitude relationship in 10 PD subjects with clinical evidence of festination and FOG. Four conditions were examined: off levodopa, ojfwith attentional strategies, off with visual cues, and on levodopa. Participants demonstrated a sequence effect (F = 6.24; P = 0.001), which was reversed only by use of visual cues. In contrast, medication, attentional strategies, and visual cues all improved hypokinesia. Variability was marked both within and between participants in all conditions. The variability of FOG is suggested to relate to a combination of factors, including the sequence effect and its variability, as well as the severity of hypokinesia and its response to medications.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Congélation; Noyau gris central
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux central
ED :	Nervous system diseases; Parkinson disease; Freezing; Basal ganglion
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Central nervous system
SD :	Sistema nervioso patología; Parkinson enfermedad; Congelación; Núcleo basal
LO :	INIST-20953.354000158780860180
ID :	06-0518096

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Pascal:06-0518096

Le document en format XML

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<front><div type="abstract" xml:lang="en">Festination and freezing of gait (FOG) are poorly understood gait disorders that cause disability and falls in people with Parkinson disease (PD). In PD, basal ganglia malfunction leads to motor set deficits (hypokinesia), while altered motor cue production leads to a sequence effect, whereby movements becomes progressively smaller as in festination. We suggest both factors may contribute to FOG. Disturbance of set maintenance by the basal ganglia in PD has previously been examined in gait, but limited systematic evaluation of the sequence effect exists. In this study, we investigated the step-to-step amplitude relationship in 10 PD subjects with clinical evidence of festination and FOG. Four conditions were examined: off levodopa, ojfwith attentional strategies, off with visual cues, and on levodopa. Participants demonstrated a sequence effect (F = 6.24; P = 0.001), which was reversed only by use of visual cues. In contrast, medication, attentional strategies, and visual cues all improved hypokinesia. Variability was marked both within and between participants in all conditions. The variability of FOG is suggested to relate to a combination of factors, including the sequence effect and its variability, as well as the severity of hypokinesia and its response to medications.</div>
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<AF>Geriatric Research Unit, Kingston Centre Southern Health/Melbourne/Australie (1 aut., 2 aut., 3 aut.); MONARC, Monash University/Melbourne/Australie (1 aut., 2 aut.); Murdoch Children's Research Institute/Melbourne/Australie (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 9; Pp. 1419-1424; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>Festination and freezing of gait (FOG) are poorly understood gait disorders that cause disability and falls in people with Parkinson disease (PD). In PD, basal ganglia malfunction leads to motor set deficits (hypokinesia), while altered motor cue production leads to a sequence effect, whereby movements becomes progressively smaller as in festination. We suggest both factors may contribute to FOG. Disturbance of set maintenance by the basal ganglia in PD has previously been examined in gait, but limited systematic evaluation of the sequence effect exists. In this study, we investigated the step-to-step amplitude relationship in 10 PD subjects with clinical evidence of festination and FOG. Four conditions were examined: off levodopa, ojfwith attentional strategies, off with visual cues, and on levodopa. Participants demonstrated a sequence effect (F = 6.24; P = 0.001), which was reversed only by use of visual cues. In contrast, medication, attentional strategies, and visual cues all improved hypokinesia. Variability was marked both within and between participants in all conditions. The variability of FOG is suggested to relate to a combination of factors, including the sequence effect and its variability, as well as the severity of hypokinesia and its response to medications.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Congélation; Noyau gris central</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux central</FG>
<ED>Nervous system diseases; Parkinson disease; Freezing; Basal ganglion</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Central nervous system</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Congelación; Núcleo basal</SD>
<LO>INIST-20953.354000158780860180</LO>
<ID>06-0518096</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

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