Validity of the 30-item geriatric depression scale in patients with Parkinson's disease
Identifieur interne : 001965 ( PascalFrancis/Corpus ); précédent : 001964; suivant : 001966Validity of the 30-item geriatric depression scale in patients with Parkinson's disease
Auteurs : William M. Mcdonald ; Paul E. Holtzheimer ; Michael Haber ; Jerrold L. Vitek ; Kimberly Mcwhorter ; Mahlon DelongSource :
- Movement disorders [ 0885-3185 ] ; 2006.
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- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Depression in Parkinson's disease (dPD) is difficult to diagnose because depressive symptoms can overlap with symptoms of Parkinson's disease (PD). Subject-rated scales such as the 30-item Geriatric Depression Scale (GDS) may be useful in screening for dPD. There were 57 patients (33 men, 24 women; mean age, 58.6 years [SD ± 8.4]) enrolled in a study of pallidotomy for intractable PD who were evaluated for depression before and after surgery. Subjects were evaluated using the 17-item Hamilton Depression Rating Scale (HDRS), Structured Clinical Interview for Diagnostic and Statistical Manual-III (SCID), and the GDS. SCID was used to diagnose major depression with confirmation by an expert geropsychiatrist. Receiver-operating curves (ROC) were used to identify cutoff points with maximal discriminant validity for diagnosing dPD. A total of 213 evaluation time points were included for the 52 patients with time points that included a valid SCID diagnosis, GDS, and HDRS. A ROC established points of maximum specificity/sensitivity for the GDS at a cutoff of 9/10 (sensitivity = 0.809, specificity = 0.837, positive predictive value [PPV] = 0.584, negative predictive value [NPV] = 0.939) and for the HDRS at a cutoff of 12/13 (sensitivity = 0.810, specificity = 0.821, PPV = 0.580, NPV = 0.934). The GDS was moderately correlated with the HDRS (Pearson's r = 0.54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients.
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Format Inist (serveur)
NO : | PASCAL 06-0538577 INIST |
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ET : | Validity of the 30-item geriatric depression scale in patients with Parkinson's disease |
AU : | MCDONALD (William M.); HOLTZHEIMER (Paul E.); HABER (Michael); VITEK (Jerrold L.); MCWHORTER (Kimberly); DELONG (Mahlon) |
AF : | Department of Psychiatry and Behavioral Sciences, Emory University/Atlanta, Georgia/Etats-Unis (1 aut., 2 aut., 5 aut.); Department of Biostatistics, Emory University/Atlanta, Georgia/Etats-Unis (3 aut.); Center for Neurological Restoration, Cleveland Clinic Foundation/Cleveland, Ohio/Etats-Unis (4 aut.); Department of Neurology, Emory University/Atlanta, Georgia/Etats-Unis (6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 10; Pp. 1618-1622; Bibl. 26 ref. |
LA : | Anglais |
EA : | Depression in Parkinson's disease (dPD) is difficult to diagnose because depressive symptoms can overlap with symptoms of Parkinson's disease (PD). Subject-rated scales such as the 30-item Geriatric Depression Scale (GDS) may be useful in screening for dPD. There were 57 patients (33 men, 24 women; mean age, 58.6 years [SD ± 8.4]) enrolled in a study of pallidotomy for intractable PD who were evaluated for depression before and after surgery. Subjects were evaluated using the 17-item Hamilton Depression Rating Scale (HDRS), Structured Clinical Interview for Diagnostic and Statistical Manual-III (SCID), and the GDS. SCID was used to diagnose major depression with confirmation by an expert geropsychiatrist. Receiver-operating curves (ROC) were used to identify cutoff points with maximal discriminant validity for diagnosing dPD. A total of 213 evaluation time points were included for the 52 patients with time points that included a valid SCID diagnosis, GDS, and HDRS. A ROC established points of maximum specificity/sensitivity for the GDS at a cutoff of 9/10 (sensitivity = 0.809, specificity = 0.837, positive predictive value [PPV] = 0.584, negative predictive value [NPV] = 0.939) and for the HDRS at a cutoff of 12/13 (sensitivity = 0.810, specificity = 0.821, PPV = 0.580, NPV = 0.934). The GDS was moderately correlated with the HDRS (Pearson's r = 0.54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients. |
CC : | 002B17; 002B17G; 002B17F |
FD : | Système nerveux pathologie; Etat dépressif; Parkinson maladie; Trouble humeur; Validité; Gériatrie; Homme |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie |
ED : | Nervous system diseases; Depression; Parkinson disease; Mood disorder; Validity; Geriatrics; Human |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Sistema nervioso patología; Estado depresivo; Parkinson enfermedad; Trastorno humor; Validez; Geriatría; Hombre |
LO : | INIST-20953.354000158877800070 |
ID : | 06-0538577 |
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Pascal:06-0538577Le document en format XML
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<front><div type="abstract" xml:lang="en">Depression in Parkinson's disease (dPD) is difficult to diagnose because depressive symptoms can overlap with symptoms of Parkinson's disease (PD). Subject-rated scales such as the 30-item Geriatric Depression Scale (GDS) may be useful in screening for dPD. There were 57 patients (33 men, 24 women; mean age, 58.6 years [SD ± 8.4]) enrolled in a study of pallidotomy for intractable PD who were evaluated for depression before and after surgery. Subjects were evaluated using the 17-item Hamilton Depression Rating Scale (HDRS), Structured Clinical Interview for Diagnostic and Statistical Manual-III (SCID), and the GDS. SCID was used to diagnose major depression with confirmation by an expert geropsychiatrist. Receiver-operating curves (ROC) were used to identify cutoff points with maximal discriminant validity for diagnosing dPD. A total of 213 evaluation time points were included for the 52 patients with time points that included a valid SCID diagnosis, GDS, and HDRS. A ROC established points of maximum specificity/sensitivity for the GDS at a cutoff of 9/10 (sensitivity = 0.809, specificity = 0.837, positive predictive value [PPV] = 0.584, negative predictive value [NPV] = 0.939) and for the HDRS at a cutoff of 12/13 (sensitivity = 0.810, specificity = 0.821, PPV = 0.580, NPV = 0.934). The GDS was moderately correlated with the HDRS (Pearson's r = 0.54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients.</div>
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<server><NO>PASCAL 06-0538577 INIST</NO>
<ET>Validity of the 30-item geriatric depression scale in patients with Parkinson's disease</ET>
<AU>MCDONALD (William M.); HOLTZHEIMER (Paul E.); HABER (Michael); VITEK (Jerrold L.); MCWHORTER (Kimberly); DELONG (Mahlon)</AU>
<AF>Department of Psychiatry and Behavioral Sciences, Emory University/Atlanta, Georgia/Etats-Unis (1 aut., 2 aut., 5 aut.); Department of Biostatistics, Emory University/Atlanta, Georgia/Etats-Unis (3 aut.); Center for Neurological Restoration, Cleveland Clinic Foundation/Cleveland, Ohio/Etats-Unis (4 aut.); Department of Neurology, Emory University/Atlanta, Georgia/Etats-Unis (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 10; Pp. 1618-1622; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>Depression in Parkinson's disease (dPD) is difficult to diagnose because depressive symptoms can overlap with symptoms of Parkinson's disease (PD). Subject-rated scales such as the 30-item Geriatric Depression Scale (GDS) may be useful in screening for dPD. There were 57 patients (33 men, 24 women; mean age, 58.6 years [SD ± 8.4]) enrolled in a study of pallidotomy for intractable PD who were evaluated for depression before and after surgery. Subjects were evaluated using the 17-item Hamilton Depression Rating Scale (HDRS), Structured Clinical Interview for Diagnostic and Statistical Manual-III (SCID), and the GDS. SCID was used to diagnose major depression with confirmation by an expert geropsychiatrist. Receiver-operating curves (ROC) were used to identify cutoff points with maximal discriminant validity for diagnosing dPD. A total of 213 evaluation time points were included for the 52 patients with time points that included a valid SCID diagnosis, GDS, and HDRS. A ROC established points of maximum specificity/sensitivity for the GDS at a cutoff of 9/10 (sensitivity = 0.809, specificity = 0.837, positive predictive value [PPV] = 0.584, negative predictive value [NPV] = 0.939) and for the HDRS at a cutoff of 12/13 (sensitivity = 0.810, specificity = 0.821, PPV = 0.580, NPV = 0.934). The GDS was moderately correlated with the HDRS (Pearson's r = 0.54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients.</EA>
<CC>002B17; 002B17G; 002B17F</CC>
<FD>Système nerveux pathologie; Etat dépressif; Parkinson maladie; Trouble humeur; Validité; Gériatrie; Homme</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Depression; Parkinson disease; Mood disorder; Validity; Geriatrics; Human</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Estado depresivo; Parkinson enfermedad; Trastorno humor; Validez; Geriatría; Hombre</SD>
<LO>INIST-20953.354000158877800070</LO>
<ID>06-0538577</ID>
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