MovDisordV3, PascalFrancis, Corpus, bibRecord, 001887

Stanley fahn lecture 2005 : The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

Identifieur interne : 001887 ( PascalFrancis/Corpus ); précédent : 001886; suivant : 001888

Stanley fahn lecture 2005 : The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

Auteurs : Heiko Braak ; Jürgen R. Bohl ; Christian M. Müller ; Udo Rüb ; Rob A. I. De Vos ; Kelly Del Tredici

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:07-0090852

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Corps inclusion, Anatomopathologie, Sporadique, Sénescence, Corps Lewy, Neurite.

English descriptors

KwdEn :
- Anatomic pathology, Inclusion body, Lewy body, Nervous system diseases, Neurite, Parkinson disease, Senescence, Sporadic.

Abstract

The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid- and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross-sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age- and gender-matched controls. Here, the staging hypothesis is critically reconsidered and discussed.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C03	`07`	`X`	`ENG`	`@0 Lewy body @5 13`
C03	`07`	`X`	`SPA`	`@0 Cuerpo Lewy @5 13`
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C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
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Format Inist (serveur)

NO :	PASCAL 07-0090852 INIST
ET :	Stanley fahn lecture 2005 : The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
AU :	BRAAK (Heiko); BOHL (Jürgen R.); MÜLLER (Christian M.); RÜB (Udo); DE VOS (Rob A. I.); DEL TREDICI (Kelly)
AF :	Institute for Clinical Neuroanatomy, J. W. Goethe University/Frankfurt/Main/Allemagne (1 aut., 3 aut., 4 aut., 6 aut.); Department of Neuropathology, Johannes Gutenberg University/Mainz/Allemagne (2 aut.); Laboratorium Pathologie Oost Nederland/Enschede/Pays-Bas (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 12; Pp. 2042-2051; Bibl. 110 ref.
LA :	Anglais
EA :	The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid- and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross-sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age- and gender-matched controls. Here, the staging hypothesis is critically reconsidered and discussed.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Corps inclusion; Anatomopathologie; Sporadique; Sénescence; Corps Lewy; Neurite
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Inclusion body; Anatomic pathology; Sporadic; Senescence; Lewy body; Neurite
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Cuerpo inclusión; Anatomía patológica; Esporádico; Senescencia; Cuerpo Lewy
LO :	INIST-20953.354000145356790020
ID :	07-0090852

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Pascal:07-0090852

Le document en format XML

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<front><div type="abstract" xml:lang="en">The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid- and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross-sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age- and gender-matched controls. Here, the staging hypothesis is critically reconsidered and discussed.</div>
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<fC01 i1="01" l="ENG"><s0>The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid- and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross-sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age- and gender-matched controls. Here, the staging hypothesis is critically reconsidered and discussed.</s0>
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<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Cuerpo inclusión</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Anatomopathologie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Anatomic pathology</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Anatomía patológica</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Sporadique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Sporadic</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Esporádico</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Sénescence</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Senescence</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Senescencia</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Corps Lewy</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Lewy body</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Cuerpo Lewy</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Neurite</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Neurite</s0>
<s5>14</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>057</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 07-0090852 INIST</NO>
<ET>Stanley fahn lecture 2005 : The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered</ET>
<AU>BRAAK (Heiko); BOHL (Jürgen R.); MÜLLER (Christian M.); RÜB (Udo); DE VOS (Rob A. I.); DEL TREDICI (Kelly)</AU>
<AF>Institute for Clinical Neuroanatomy, J. W. Goethe University/Frankfurt/Main/Allemagne (1 aut., 3 aut., 4 aut., 6 aut.); Department of Neuropathology, Johannes Gutenberg University/Mainz/Allemagne (2 aut.); Laboratorium Pathologie Oost Nederland/Enschede/Pays-Bas (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 12; Pp. 2042-2051; Bibl. 110 ref.</SO>
<LA>Anglais</LA>
<EA>The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid- and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross-sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age- and gender-matched controls. Here, the staging hypothesis is critically reconsidered and discussed.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Corps inclusion; Anatomopathologie; Sporadique; Sénescence; Corps Lewy; Neurite</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Inclusion body; Anatomic pathology; Sporadic; Senescence; Lewy body; Neurite</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Cuerpo inclusión; Anatomía patológica; Esporádico; Senescencia; Cuerpo Lewy</SD>
<LO>INIST-20953.354000145356790020</LO>
<ID>07-0090852</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Stanley fahn lecture 2005 : The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

Stanley fahn lecture 2005 : The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

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