MovDisordV3, PascalFrancis, Corpus, bibRecord, 001775

Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease

Identifieur interne : 001775 ( PascalFrancis/Corpus ); précédent : 001774; suivant : 001776

Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease

Auteurs : Richard M. Camicioli ; Christopher C. Hanstock ; Thomas P. Bouchard ; Myrlene Gee ; Nancy J. Fisher ; W. R. Wayne Martin

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0181698

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Trouble fonctionnel, Spectrométrie RMN, Signe, Echelle d'évaluation.

English descriptors

KwdEn :
- Dysfunction, Evaluation scale, NMR spectrometry, Nervous system diseases, Parkinson disease, Sign.

Abstract

The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease`
A11	`01`	`1`		`@1 CAMICIOLI (Richard M.)`
A11	`02`	`1`		`@1 HANSTOCK (Christopher C.)`
A11	`03`	`1`		`@1 BOUCHARD (Thomas P.)`
A11	`04`	`1`		`@1 GEE (Myrlene)`
A11	`05`	`1`		`@1 FISHER (Nancy J.)`
A11	`06`	`1`		`@1 MARTIN (W. R. Wayne)`
A14	`01`			`@1 Department of Medicine (Neurology), University of Alberta @2 Edmonton, Alberta @3 CAN @Z 1 aut. @Z 3 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Biomedical Engineering, University of Alberta @2 Edmonton, Alberta @3 CAN @Z 2 aut. @Z 4 aut.`
A14	`03`			`@1 Division of Neurosciences, University of Alberta @2 Edmonton, Alberta @3 CAN @Z 5 aut.`
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A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD.
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C03	`04`	`X`	`ENG`	`@0 NMR spectrometry @5 10`
C03	`04`	`X`	`SPA`	`@0 Espectrometría RMN @5 10`
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C03	`06`	`X`	`FRE`	`@0 Echelle d'évaluation @5 12`
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C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
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C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
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C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
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C07	`04`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 40`
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Format Inist (serveur)

NO :	PASCAL 07-0181698 INIST
ET :	Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease
AU :	CAMICIOLI (Richard M.); HANSTOCK (Christopher C.); BOUCHARD (Thomas P.); GEE (Myrlene); FISHER (Nancy J.); MARTIN (W. R. Wayne)
AF :	Department of Medicine (Neurology), University of Alberta/Edmonton, Alberta/Canada (1 aut., 3 aut., 6 aut.); Department of Biomedical Engineering, University of Alberta/Edmonton, Alberta/Canada (2 aut., 4 aut.); Division of Neurosciences, University of Alberta/Edmonton, Alberta/Canada (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 3; Pp. 382-386; Bibl. 36 ref.
LA :	Anglais
EA :	The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD.
CC :	002B17; 002B17G; 002B24A06
FD :	Système nerveux pathologie; Parkinson maladie; Trouble fonctionnel; Spectrométrie RMN; Signe; Echelle d'évaluation
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Dysfunction; NMR spectrometry; Sign; Evaluation scale
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Trastorno funcional; Espectrometría RMN; Signo; Escala evaluación
LO :	INIST-20953.354000159377420150
ID :	07-0181698

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Pascal:07-0181698

Le document en format XML

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<front><div type="abstract" xml:lang="en">The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD.</div>
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<fC01 i1="01" l="ENG"><s0>The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD.</s0>
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<s5>09</s5>
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<s5>09</s5>
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<s5>09</s5>
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<s5>10</s5>
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<s5>12</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Escala evaluación</s0>
<s5>12</s5>
</fC03>
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<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
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<server><NO>PASCAL 07-0181698 INIST</NO>
<ET>Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease</ET>
<AU>CAMICIOLI (Richard M.); HANSTOCK (Christopher C.); BOUCHARD (Thomas P.); GEE (Myrlene); FISHER (Nancy J.); MARTIN (W. R. Wayne)</AU>
<AF>Department of Medicine (Neurology), University of Alberta/Edmonton, Alberta/Canada (1 aut., 3 aut., 6 aut.); Department of Biomedical Engineering, University of Alberta/Edmonton, Alberta/Canada (2 aut., 4 aut.); Division of Neurosciences, University of Alberta/Edmonton, Alberta/Canada (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 3; Pp. 382-386; Bibl. 36 ref.</SO>
<LA>Anglais</LA>
<EA>The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 ± 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 ± 0.17; control: 1.47 ± 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01), but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD.</EA>
<CC>002B17; 002B17G; 002B24A06</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Trouble fonctionnel; Spectrométrie RMN; Signe; Echelle d'évaluation</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Dysfunction; NMR spectrometry; Sign; Evaluation scale</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Trastorno funcional; Espectrometría RMN; Signo; Escala evaluación</SD>
<LO>INIST-20953.354000159377420150</LO>
<ID>07-0181698</ID>
</server>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease

Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease

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