MovDisordV3, PascalFrancis, Corpus, bibRecord, 001755

Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes

Identifieur interne : 001755 ( PascalFrancis/Corpus ); précédent : 001754; suivant : 001756

Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes

Auteurs : Birgit Herting ; Bettina Beuthien-Baumann ; Katrin Pottrich ; Markus Donix ; Antje Triemer ; Johannes B. Lampe ; Rüdiger Von Kummer ; Karl Herholz ; Heinz Reichmann ; Vjera A. Holthoff

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0210947

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Etat dépressif, Parkinson maladie, Atrophie multisystématisée, Cortex préfrontal, Trouble fonctionnel, Tomographie, Lobe frontal.

English descriptors

KwdEn :
- Depression, Dysfunction, Frontal lobe, Multiple system atrophy, Nervous system diseases, Parkinson disease, Prefrontal cortex, Tomography.

Abstract

Depressive symptoms are common in patients with neurodegenerative disorders. Imaging studies suggest that a disruption of frontal-subcortical pathways may underlie depression associated with basal ganglia disease. This pilot study tested the hypothesis that frontal dysfunction contributes to depression associated with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Depressed patients with MSA (n = 11), PSP (n = 9), and age-matched controls (n = 25) underwent measures of cerebral glucose metabolism applying positron emission tomography with ' ¹⁸F-fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel-based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`03`			`@1 Department of Psychiatry and Psychotherapy, Technische Universität Dresden @3 DEU @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 10 aut.`
A14	`04`			`@1 Department of Neuroradiology, Technische Universität Dresden @3 DEU @Z 7 aut.`
A14	`05`			`@1 Manchester Molecular Imaging Center @2 Manchester, England @3 GBR @Z 8 aut.`
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C01	`01`		`ENG`	@0 Depressive symptoms are common in patients with neurodegenerative disorders. Imaging studies suggest that a disruption of frontal-subcortical pathways may underlie depression associated with basal ganglia disease. This pilot study tested the hypothesis that frontal dysfunction contributes to depression associated with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Depressed patients with MSA (n = 11), PSP (n = 9), and age-matched controls (n = 25) underwent measures of cerebral glucose metabolism applying positron emission tomography with ' ¹⁸F-fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel-based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction.
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C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
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C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
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Format Inist (serveur)

NO :	PASCAL 07-0210947 INIST
ET :	Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes
AU :	HERTING (Birgit); BEUTHIEN-BAUMANN (Bettina); POTTRICH (Katrin); DONIX (Markus); TRIEMER (Antje); LAMPE (Johannes B.); VON KUMMER (Rüdiger); HERHOLZ (Karl); REICHMANN (Heinz); HOLTHOFF (Vjera A.)
AF :	Department of Neurology, Technische Universität Dresden/Allemagne (1 aut., 6 aut., 9 aut.); Department of Nuclear Medicine, Technische Universität Dresden and PET-Center, Research Center Rossendorf/Allemagne (2 aut.); Department of Psychiatry and Psychotherapy, Technische Universität Dresden/Allemagne (3 aut., 4 aut., 5 aut., 10 aut.); Department of Neuroradiology, Technische Universität Dresden/Allemagne (7 aut.); Manchester Molecular Imaging Center/Manchester, England/Royaume-Uni (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 4; Pp. 490-497; Bibl. 43 ref.
LA :	Anglais
EA :	Depressive symptoms are common in patients with neurodegenerative disorders. Imaging studies suggest that a disruption of frontal-subcortical pathways may underlie depression associated with basal ganglia disease. This pilot study tested the hypothesis that frontal dysfunction contributes to depression associated with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Depressed patients with MSA (n = 11), PSP (n = 9), and age-matched controls (n = 25) underwent measures of cerebral glucose metabolism applying positron emission tomography with ' ¹⁸F-fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel-based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction.
CC :	002B17; 002B17D; 002B17F
FD :	Système nerveux pathologie; Etat dépressif; Parkinson maladie; Atrophie multisystématisée; Cortex préfrontal; Trouble fonctionnel; Tomographie; Lobe frontal
FG :	Encéphale pathologie; Système nerveux central; Trouble humeur; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Depression; Parkinson disease; Multiple system atrophy; Prefrontal cortex; Dysfunction; Tomography; Frontal lobe
EG :	Cerebral disorder; Central nervous system; Mood disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Estado depresivo; Parkinson enfermedad; Atrofia multisistematizada; Corteza prefrontal; Trastorno funcional; Tomografía; Lóbulo frontal
LO :	INIST-20953.354000145702210060
ID :	07-0210947

Links to Exploration step

Pascal:07-0210947

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Depression</term>
<term>Dysfunction</term>
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<term>Nervous system diseases</term>
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<term>Prefrontal cortex</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Etat dépressif</term>
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<term>Atrophie multisystématisée</term>
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<term>Trouble fonctionnel</term>
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<term>Lobe frontal</term>
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<front><div type="abstract" xml:lang="en">Depressive symptoms are common in patients with neurodegenerative disorders. Imaging studies suggest that a disruption of frontal-subcortical pathways may underlie depression associated with basal ganglia disease. This pilot study tested the hypothesis that frontal dysfunction contributes to depression associated with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Depressed patients with MSA (n = 11), PSP (n = 9), and age-matched controls (n = 25) underwent measures of cerebral glucose metabolism applying positron emission tomography with ' <sup>18</sup>
F-fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel-based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction.</div>
</front>
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F-fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel-based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction.</s0>
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<server><NO>PASCAL 07-0210947 INIST</NO>
<ET>Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes</ET>
<AU>HERTING (Birgit); BEUTHIEN-BAUMANN (Bettina); POTTRICH (Katrin); DONIX (Markus); TRIEMER (Antje); LAMPE (Johannes B.); VON KUMMER (Rüdiger); HERHOLZ (Karl); REICHMANN (Heinz); HOLTHOFF (Vjera A.)</AU>
<AF>Department of Neurology, Technische Universität Dresden/Allemagne (1 aut., 6 aut., 9 aut.); Department of Nuclear Medicine, Technische Universität Dresden and PET-Center, Research Center Rossendorf/Allemagne (2 aut.); Department of Psychiatry and Psychotherapy, Technische Universität Dresden/Allemagne (3 aut., 4 aut., 5 aut., 10 aut.); Department of Neuroradiology, Technische Universität Dresden/Allemagne (7 aut.); Manchester Molecular Imaging Center/Manchester, England/Royaume-Uni (8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 4; Pp. 490-497; Bibl. 43 ref.</SO>
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<EA>Depressive symptoms are common in patients with neurodegenerative disorders. Imaging studies suggest that a disruption of frontal-subcortical pathways may underlie depression associated with basal ganglia disease. This pilot study tested the hypothesis that frontal dysfunction contributes to depression associated with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Depressed patients with MSA (n = 11), PSP (n = 9), and age-matched controls (n = 25) underwent measures of cerebral glucose metabolism applying positron emission tomography with ' <sup>18</sup>
F-fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel-based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction.</EA>
<CC>002B17; 002B17D; 002B17F</CC>
<FD>Système nerveux pathologie; Etat dépressif; Parkinson maladie; Atrophie multisystématisée; Cortex préfrontal; Trouble fonctionnel; Tomographie; Lobe frontal</FD>
<FG>Encéphale pathologie; Système nerveux central; Trouble humeur; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Depression; Parkinson disease; Multiple system atrophy; Prefrontal cortex; Dysfunction; Tomography; Frontal lobe</ED>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes

Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes

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