MovDisordV3, PascalFrancis, Corpus, bibRecord, 001705

Characteristics of apathy in Parkinson's disease

Identifieur interne : 001705 ( PascalFrancis/Corpus ); précédent : 001704; suivant : 001706

Characteristics of apathy in Parkinson's disease

Auteurs : Kathy Dujardin ; Pascal Sockeel ; David Devos ; Marie Delliaux ; Pierre Krystkowiak ; Alain Destee ; Luc Defebvre

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0263052

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Etat dépressif, Noyau gris central, Motivation, Comportement, Apathie.

English descriptors

KwdEn :
- Apathy, Basal ganglion, Behavior, Depression, Motivation, Nervous system diseases, Parkinson disease.

Abstract

The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty-nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multi-variate analyses of variance. Thirty-two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal-subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty-nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multi-variate analyses of variance. Thirty-two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal-subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits.
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Format Inist (serveur)

NO :	PASCAL 07-0263052 INIST
ET :	Characteristics of apathy in Parkinson's disease
AU :	DUJARDIN (Kathy); SOCKEEL (Pascal); DEVOS (David); DELLIAUX (Marie); KRYSTKOWIAK (Pierre); DESTEE (Alain); DEFEBVRE (Luc)
AF :	Neurology and Movement Disorders Unit, EA2683, Faculty of Medicine and Lille University Hospital/Lille/France (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); Psychology Department, Charles De Gaulle University/Lille/France (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 6; Pp. 778-784; Bibl. 32 ref.
LA :	Anglais
EA :	The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty-nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multi-variate analyses of variance. Thirty-two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal-subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Etat dépressif; Noyau gris central; Motivation; Comportement; Apathie
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux central; Trouble humeur
ED :	Nervous system diseases; Parkinson disease; Depression; Basal ganglion; Motivation; Behavior; Apathy
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Central nervous system; Mood disorder
SD :	Sistema nervioso patología; Parkinson enfermedad; Estado depresivo; Núcleo basal; Motivación; Conducta; Apatía
LO :	INIST-20953.354000149445250030
ID :	07-0263052

Links to Exploration step

Pascal:07-0263052

Le document en format XML

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<front><div type="abstract" xml:lang="en">The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty-nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multi-variate analyses of variance. Thirty-two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal-subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits.</div>
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<s5>39</s5>
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<s5>40</s5>
</fC07>
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<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
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<s5>41</s5>
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<s5>41</s5>
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<s5>41</s5>
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<server><NO>PASCAL 07-0263052 INIST</NO>
<ET>Characteristics of apathy in Parkinson's disease</ET>
<AU>DUJARDIN (Kathy); SOCKEEL (Pascal); DEVOS (David); DELLIAUX (Marie); KRYSTKOWIAK (Pierre); DESTEE (Alain); DEFEBVRE (Luc)</AU>
<AF>Neurology and Movement Disorders Unit, EA2683, Faculty of Medicine and Lille University Hospital/Lille/France (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); Psychology Department, Charles De Gaulle University/Lille/France (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 6; Pp. 778-784; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty-nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multi-variate analyses of variance. Thirty-two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal-subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Etat dépressif; Noyau gris central; Motivation; Comportement; Apathie</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux central; Trouble humeur</FG>
<ED>Nervous system diseases; Parkinson disease; Depression; Basal ganglion; Motivation; Behavior; Apathy</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Central nervous system; Mood disorder</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Estado depresivo; Núcleo basal; Motivación; Conducta; Apatía</SD>
<LO>INIST-20953.354000149445250030</LO>
<ID>07-0263052</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Characteristics of apathy in Parkinson's disease

Characteristics of apathy in Parkinson's disease

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