MovDisordV3, PascalFrancis, Corpus, bibRecord, 001548

Mild parkinsonian signs : An overview of an emerging concept

Identifieur interne : 001548 ( PascalFrancis/Corpus ); précédent : 001547; suivant : 001549

Mild parkinsonian signs : An overview of an emerging concept

Auteurs : Elan D. Louis ; David A. Bennett

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0491114

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Parkinsonisme, Signe, Sénescence, Personne âgée, Epidémiologie.

English descriptors

KwdEn :
- Elderly, Epidemiology, Nervous system diseases, Parkinson disease, Parkinsonism, Senescence, Sign.

Abstract

Mild Parkinsonian signs (MPS) include gait and balance changes, rigidity, bradykinesia, and tremor. MPS can balance changes, rigidity, bradykinesia, and tremor. MPS can occur commonly during the clinical examination of older people who do not have known neurological disease, with prevalence estimates for MPS as a whole ranging from 15% to 95%. MPS are generally progressive and they are coupled with functional difficulties, impaired gait and balance, and increased risks of mild cognitive impairment, dementia, and mortality. The mechanistic basis for these signs is unclear, but is likely to be multifactorial, with possible factors including an age-associated decline in dopaminergic nigrostriatal activity, the early development of neurodegenerative (Lewy body or Alzheimer's type) pathologies in the basal ganglia, or the accumulation of vascular pathology in the brain. It would be valuable to identify those individuals with MPS who are at increased risk for the development of future Alzheimer's disease, full-blown Parkinson's disease, or strokes, and to develop therapeutic strategies to intervene to lessen the likelihood of MPS-related morbidity and mortality.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 07-0491114 INIST
ET :	Mild parkinsonian signs : An overview of an emerging concept
AU :	LOUIS (Elan D.); BENNETT (David A.)
AF :	G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut.); Rush Alzheimer's Disease Center, Rush University Medical Center/Chicago, Illinois/Etats-Unis (2 aut.); Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 12; Pp. 1681-1688; Bibl. 75 ref.
LA :	Anglais
EA :	Mild Parkinsonian signs (MPS) include gait and balance changes, rigidity, bradykinesia, and tremor. MPS can balance changes, rigidity, bradykinesia, and tremor. MPS can occur commonly during the clinical examination of older people who do not have known neurological disease, with prevalence estimates for MPS as a whole ranging from 15% to 95%. MPS are generally progressive and they are coupled with functional difficulties, impaired gait and balance, and increased risks of mild cognitive impairment, dementia, and mortality. The mechanistic basis for these signs is unclear, but is likely to be multifactorial, with possible factors including an age-associated decline in dopaminergic nigrostriatal activity, the early development of neurodegenerative (Lewy body or Alzheimer's type) pathologies in the basal ganglia, or the accumulation of vascular pathology in the brain. It would be valuable to identify those individuals with MPS who are at increased risk for the development of future Alzheimer's disease, full-blown Parkinson's disease, or strokes, and to develop therapeutic strategies to intervene to lessen the likelihood of MPS-related morbidity and mortality.
CC :	002B17; 002B05C02D; 002B17G
FD :	Système nerveux pathologie; Parkinson maladie; Parkinsonisme; Signe; Sénescence; Personne âgée; Epidémiologie
FG :	Homme; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Parkinsonism; Sign; Senescence; Elderly; Epidemiology
EG :	Human; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Parkinson síndrome; Signo; Senescencia; Anciano; Epidemiología
LO :	INIST-20953.354000143464810010
ID :	07-0491114

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Pascal:07-0491114

Le document en format XML

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<ET>Mild parkinsonian signs : An overview of an emerging concept</ET>
<AU>LOUIS (Elan D.); BENNETT (David A.)</AU>
<AF>G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut.); Rush Alzheimer's Disease Center, Rush University Medical Center/Chicago, Illinois/Etats-Unis (2 aut.); Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 12; Pp. 1681-1688; Bibl. 75 ref.</SO>
<LA>Anglais</LA>
<EA>Mild Parkinsonian signs (MPS) include gait and balance changes, rigidity, bradykinesia, and tremor. MPS can balance changes, rigidity, bradykinesia, and tremor. MPS can occur commonly during the clinical examination of older people who do not have known neurological disease, with prevalence estimates for MPS as a whole ranging from 15% to 95%. MPS are generally progressive and they are coupled with functional difficulties, impaired gait and balance, and increased risks of mild cognitive impairment, dementia, and mortality. The mechanistic basis for these signs is unclear, but is likely to be multifactorial, with possible factors including an age-associated decline in dopaminergic nigrostriatal activity, the early development of neurodegenerative (Lewy body or Alzheimer's type) pathologies in the basal ganglia, or the accumulation of vascular pathology in the brain. It would be valuable to identify those individuals with MPS who are at increased risk for the development of future Alzheimer's disease, full-blown Parkinson's disease, or strokes, and to develop therapeutic strategies to intervene to lessen the likelihood of MPS-related morbidity and mortality.</EA>
<CC>002B17; 002B05C02D; 002B17G</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Parkinsonisme; Signe; Sénescence; Personne âgée; Epidémiologie</FD>
<FG>Homme; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Parkinsonism; Sign; Senescence; Elderly; Epidemiology</ED>
<EG>Human; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Parkinson síndrome; Signo; Senescencia; Anciano; Epidemiología</SD>
<LO>INIST-20953.354000143464810010</LO>
<ID>07-0491114</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Mild parkinsonian signs : An overview of an emerging concept

Mild parkinsonian signs : An overview of an emerging concept

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