MovDisordV3, PascalFrancis, Corpus, bibRecord, 001537

Diffusion weighted imaging best discriminates PD from MSA-P : A comparison with tilt table testing and heart MIBG scintigraphy

Identifieur interne : 001537 ( PascalFrancis/Corpus ); précédent : 001536; suivant : 001538

Diffusion weighted imaging best discriminates PD from MSA-P : A comparison with tilt table testing and heart MIBG scintigraphy

Auteurs : Martin Köllensperger ; Klaus Seppi ; Claudia Liener ; Sylvia Boesch ; Dirk Heute ; Katherina J. Mair ; Joerg Mueller ; Martin Sawires ; Christoph Scherfler ; Michael F. Schocke ; Eveline Donnemiller ; Irene Virgolini ; Gregor K. Wenning ; Werner Poewe

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0491125

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Atrophie multisystématisée, Etude comparative, Table basculante, Scintigraphie, Imagerie de diffusion.

English descriptors

KwdEn :
- Comparative study, Diffusion imaging, Multiple system atrophy, Nervous system diseases, Parkinson disease, Scintigraphy, Tilt table.

Abstract

Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta-iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA-P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA-P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA-P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 07-0491125 INIST
ET :	Diffusion weighted imaging best discriminates PD from MSA-P : A comparison with tilt table testing and heart MIBG scintigraphy
AU :	KÖLLENSPERGER (Martin); SEPPI (Klaus); LIENER (Claudia); BOESCH (Sylvia); HEUTE (Dirk); MAIR (Katherina J.); MUELLER (Joerg); SAWIRES (Martin); SCHERFLER (Christoph); SCHOCKE (Michael F.); DONNEMILLER (Eveline); VIRGOLINI (Irene); WENNING (Gregor K.); POEWE (Werner)
AF :	Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35/6020 Innsbruck/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 11 aut., 12 aut., 13 aut., 14 aut.); Department of Radiology I, Innsbruck Medical University, Anichstraβe 35/6020 Innsbruck/Autriche (10 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 12; Pp. 1771-1776; Bibl. 40 ref.
LA :	Anglais
EA :	Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta-iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA-P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA-P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA-P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P.
CC :	002B17; 002B24A06; 002B17C
FD :	Système nerveux pathologie; Parkinson maladie; Atrophie multisystématisée; Etude comparative; Table basculante; Scintigraphie; Imagerie de diffusion
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Multiple system atrophy; Comparative study; Tilt table; Scintigraphy; Diffusion imaging
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Atrofia multisistematizada; Estudio comparativo; Mesa basculante; Centelleografía
LO :	INIST-20953.354000143464810120
ID :	07-0491125

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Pascal:07-0491125

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Diffusion weighted imaging best discriminates PD from MSA-P : A comparison with tilt table testing and heart MIBG scintigraphy</title>
<author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term>
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<term>Parkinson disease</term>
<term>Scintigraphy</term>
<term>Tilt table</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Atrophie multisystématisée</term>
<term>Etude comparative</term>
<term>Table basculante</term>
<term>Scintigraphie</term>
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<front><div type="abstract" xml:lang="en">Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta-iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA-P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA-P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA-P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P.</div>
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<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>323</s1>
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<server><NO>PASCAL 07-0491125 INIST</NO>
<ET>Diffusion weighted imaging best discriminates PD from MSA-P : A comparison with tilt table testing and heart MIBG scintigraphy</ET>
<AU>KÖLLENSPERGER (Martin); SEPPI (Klaus); LIENER (Claudia); BOESCH (Sylvia); HEUTE (Dirk); MAIR (Katherina J.); MUELLER (Joerg); SAWIRES (Martin); SCHERFLER (Christoph); SCHOCKE (Michael F.); DONNEMILLER (Eveline); VIRGOLINI (Irene); WENNING (Gregor K.); POEWE (Werner)</AU>
<AF>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35/6020 Innsbruck/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 11 aut., 12 aut., 13 aut., 14 aut.); Department of Radiology I, Innsbruck Medical University, Anichstraβe 35/6020 Innsbruck/Autriche (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 12; Pp. 1771-1776; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta-iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA-P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA-P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA-P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P.</EA>
<CC>002B17; 002B24A06; 002B17C</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Atrophie multisystématisée; Etude comparative; Table basculante; Scintigraphie; Imagerie de diffusion</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Multiple system atrophy; Comparative study; Tilt table; Scintigraphy; Diffusion imaging</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Atrofia multisistematizada; Estudio comparativo; Mesa basculante; Centelleografía</SD>
<LO>INIST-20953.354000143464810120</LO>
<ID>07-0491125</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Diffusion weighted imaging best discriminates PD from MSA-P : A comparison with tilt table testing and heart MIBG scintigraphy

Diffusion weighted imaging best discriminates PD from MSA-P : A comparison with tilt table testing and heart MIBG scintigraphy

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