MovDisordV3, PascalFrancis, Corpus, bibRecord, 001524

Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy

Identifieur interne : 001524 ( PascalFrancis/Corpus ); précédent : 001523; suivant : 001525

Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy

Auteurs : Jose Enrique Martinez-Rodriguez ; Klaus Seppi ; Adriana Cardozo ; Alex Iranzo ; Michaela Stampfer-Kountchev ; Gregor Wenning ; Eduardo Tolosa ; Birgit Högl ; Joan Santamaria ; Werner Poewe

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0491138

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Atrophie multisystématisée, Liquide céphalorachidien.

English descriptors

KwdEn :
- Cerebrospinal fluid, Multiple system atrophy, Nervous system diseases.

Abstract

Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 22`
A06				`@2 12`
A08	`01`	`1`	`ENG`	`@1 Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy`
A11	`01`	`1`		`@1 ENRIQUE MARTINEZ-RODRIGUEZ (Jose)`
A11	`02`	`1`		`@1 SEPPI (Klaus)`
A11	`03`	`1`		`@1 CARDOZO (Adriana)`
A11	`04`	`1`		`@1 IRANZO (Alex)`
A11	`05`	`1`		`@1 STAMPFER-KOUNTCHEV (Michaela)`
A11	`06`	`1`		`@1 WENNING (Gregor)`
A11	`07`	`1`		`@1 TOLOSA (Eduardo)`
A11	`08`	`1`		`@1 HÖGL (Birgit)`
A11	`09`	`1`		`@1 SANTAMARIA (Joan)`
A11	`10`	`1`		`@1 POEWE (Werner)`
A14	`01`			`@1 Neurology Service, Hospital Clinic de Barcelona and Institut d'Investigacio Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona Medical School @2 Barcelona @3 ESP @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 7 aut. @Z 9 aut.`
A14	`02`			`@1 Clinical Department of Neurology, Innsbruck Medical University @2 Innsbruck @3 AUT @Z 2 aut. @Z 5 aut. @Z 6 aut. @Z 8 aut. @Z 10 aut.`
A17	`01`	`1`		`@1 SINBAR (Sleep Innsbruck Barcelona) group @3 INC`
A20				`@1 1822-1824`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000143464810250`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 07-0491138`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17F`
C02	`03`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Atrophie multisystématisée @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Multiple system atrophy @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Atrofia multisistematizada @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Liquide céphalorachidien @5 09`
C03	`03`	`X`	`ENG`	`@0 Cerebrospinal fluid @5 09`
C03	`03`	`X`	`SPA`	`@0 Líquido cefalorraquídeo @5 09`
N21				`@1 323`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0491138 INIST
ET :	Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy
AU :	ENRIQUE MARTINEZ-RODRIGUEZ (Jose); SEPPI (Klaus); CARDOZO (Adriana); IRANZO (Alex); STAMPFER-KOUNTCHEV (Michaela); WENNING (Gregor); TOLOSA (Eduardo); HÖGL (Birgit); SANTAMARIA (Joan); POEWE (Werner)
AF :	Neurology Service, Hospital Clinic de Barcelona and Institut d'Investigacio Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona Medical School/Barcelona/Espagne (1 aut., 3 aut., 4 aut., 7 aut., 9 aut.); Clinical Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (2 aut., 5 aut., 6 aut., 8 aut., 10 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 12; Pp. 1822-1824; Bibl. 15 ref.
LA :	Anglais
EA :	Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.
CC :	002B17; 002B17F; 002B17G
FD :	Système nerveux pathologie; Atrophie multisystématisée; Liquide céphalorachidien
ED :	Nervous system diseases; Multiple system atrophy; Cerebrospinal fluid
SD :	Sistema nervioso patología; Atrofia multisistematizada; Líquido cefalorraquídeo
LO :	INIST-20953.354000143464810250
ID :	07-0491138

Links to Exploration step

Pascal:07-0491138

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy</title>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrospinal fluid</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.</div>
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<fA14 i1="02"><s1>Clinical Department of Neurology, Innsbruck Medical University</s1>
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<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA17 i1="01" i2="1"><s1>SINBAR (Sleep Innsbruck Barcelona) group</s1>
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<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
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<fC01 i1="01" l="ENG"><s0>Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.</s0>
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<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Multiple system atrophy</s0>
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</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0>
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<s5>09</s5>
</fC03>
<fN21><s1>323</s1>
</fN21>
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<server><NO>PASCAL 07-0491138 INIST</NO>
<ET>Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy</ET>
<AU>ENRIQUE MARTINEZ-RODRIGUEZ (Jose); SEPPI (Klaus); CARDOZO (Adriana); IRANZO (Alex); STAMPFER-KOUNTCHEV (Michaela); WENNING (Gregor); TOLOSA (Eduardo); HÖGL (Birgit); SANTAMARIA (Joan); POEWE (Werner)</AU>
<AF>Neurology Service, Hospital Clinic de Barcelona and Institut d'Investigacio Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona Medical School/Barcelona/Espagne (1 aut., 3 aut., 4 aut., 7 aut., 9 aut.); Clinical Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (2 aut., 5 aut., 6 aut., 8 aut., 10 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 12; Pp. 1822-1824; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin-1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease.</EA>
<CC>002B17; 002B17F; 002B17G</CC>
<FD>Système nerveux pathologie; Atrophie multisystématisée; Liquide céphalorachidien</FD>
<ED>Nervous system diseases; Multiple system atrophy; Cerebrospinal fluid</ED>
<SD>Sistema nervioso patología; Atrofia multisistematizada; Líquido cefalorraquídeo</SD>
<LO>INIST-20953.354000143464810250</LO>
<ID>07-0491138</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy

Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy

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