MovDisordV3, PascalFrancis, Corpus, bibRecord, 001470

Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern

Identifieur interne : 001470 ( PascalFrancis/Corpus ); précédent : 001469; suivant : 001471

Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern

Auteurs : Antonio P. Strafella ; Andres M. Lozano ; Anthony E. Lang ; JI HYUN KO ; Yu-Yan Poon ; Elena Moro

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0069705

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Maladie de Parkinson, Sousdural, Cortex moteur, Tomoscintigraphie, Positon, Tomographie par émission de positons, Imagerie fonctionnelle.

English descriptors

KwdEn :
- Emission tomography, Functional imaging, Motor cortex, Nervous system diseases, Parkinson disease, Positron, Positron emission tomography, Subdural.

Abstract

There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [¹⁵O] H₂O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 LOZANO (Andres M.)`
A11	`03`	`1`		`@1 LANG (Anthony E.)`
A11	`04`	`1`		`@1 JI HYUN KO`
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A14	`03`			`@1 Department of Neurosurgery, Toronto Western Hospital, University of Toronto @2 Toronto, Ontario @3 CAN @Z 2 aut.`
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A61				`@0 A`
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C01	`01`		`ENG`	@0 There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [¹⁵O] H₂O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.
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C03	`03`	`X`	`SPA`	`@0 Subdural @5 09`
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C03	`07`	`X`	`FRE`	`@0 Tomographie par émission de positons @5 13`
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C03	`07`	`X`	`SPA`	`@0 Tomografía emisión positrones @5 13`
C03	`08`	`X`	`FRE`	`@0 Imagerie fonctionnelle @5 14`
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C03	`08`	`X`	`SPA`	`@0 Imaginería funcional @5 14`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Voie motrice @5 39`
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C07	`04`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 40`
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Format Inist (serveur)

NO :	PASCAL 08-0069705 INIST
ET :	Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern
AU :	STRAFELLA (Antonio P.); LOZANO (Andres M.); LANG (Anthony E.); JI HYUN KO; POON (Yu-Yan); MORO (Elena)
AF :	Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut., 5 aut., 6 aut.); PET Imaging Centre, Centre for Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.); Montreal Neurological Institute, McGill University/Montreal, Quebec/Canada (4 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 14; Pp. 2113-2116; Bibl. 27 ref.
LA :	Anglais
EA :	There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [¹⁵O] H₂O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.
CC :	002B17; 002B17G; 002B17A03
FD :	Pathologie du système nerveux; Maladie de Parkinson; Sousdural; Cortex moteur; Tomoscintigraphie; Positon; Tomographie par émission de positons; Imagerie fonctionnelle
FG :	Encéphale; Système nerveux central; Voie motrice; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Nervous system diseases; Parkinson disease; Subdural; Motor cortex; Emission tomography; Positron; Positron emission tomography; Functional imaging
EG :	Encephalon; Central nervous system; Motor pathway; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Subdural; Corteza motora; Tomocentelleografía; Positrón; Tomografía emisión positrones; Imaginería funcional
LO :	INIST-20953.354000174393170160
ID :	08-0069705

Links to Exploration step

Pascal:08-0069705

Le document en format XML

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<front><div type="abstract" xml:lang="en">There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.</div>
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<fC01 i1="01" l="ENG"><s0>There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17A03</s0>
</fC02>
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<s5>01</s5>
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<s5>01</s5>
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<s5>01</s5>
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<s2>NM</s2>
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<s5>09</s5>
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<s5>09</s5>
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</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Emission tomography</s0>
<s5>11</s5>
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<fC03 i1="07" i2="X" l="SPA"><s0>Tomografía emisión positrones</s0>
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<fC03 i1="08" i2="X" l="FRE"><s0>Imagerie fonctionnelle</s0>
<s5>14</s5>
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<fC03 i1="08" i2="X" l="ENG"><s0>Functional imaging</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Imaginería funcional</s0>
<s5>14</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>39</s5>
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<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vía motora</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>43</s5>
</fC07>
<fN21><s1>035</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 08-0069705 INIST</NO>
<ET>Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern</ET>
<AU>STRAFELLA (Antonio P.); LOZANO (Andres M.); LANG (Anthony E.); JI HYUN KO; POON (Yu-Yan); MORO (Elena)</AU>
<AF>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut., 5 aut., 6 aut.); PET Imaging Centre, Centre for Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.); Montreal Neurological Institute, McGill University/Montreal, Quebec/Canada (4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 14; Pp. 2113-2116; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Pathologie du   système nerveux; Maladie de Parkinson; Sousdural; Cortex moteur; Tomoscintigraphie; Positon; Tomographie par émission de positons; Imagerie fonctionnelle</FD>
<FG>Encéphale; Système nerveux central; Voie motrice; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Nervous system diseases; Parkinson disease; Subdural; Motor cortex; Emission tomography; Positron; Positron emission tomography; Functional imaging</ED>
<EG>Encephalon; Central nervous system; Motor pathway; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Subdural; Corteza motora; Tomocentelleografía; Positrón; Tomografía emisión positrones; Imaginería funcional</SD>
<LO>INIST-20953.354000174393170160</LO>
<ID>08-0069705</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern

Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern

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