MovDisordV3, PascalFrancis, Corpus, bibRecord, 001459

Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait

Identifieur interne : 001459 ( PascalFrancis/Corpus ); précédent : 001458; suivant : 001460

Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait

Auteurs : CHUL HYOUNG LYOO ; Sargo Aalto ; Juha O. Rinne ; KI OOK LEE ; SEUNG HUN OH ; JIN WOO CHANG ; MYUNG SIK LEE

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0071402

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Maladie de Parkinson, Encéphale, Noyau sousthalamique, Noyau moteur, Congélation, Tomoscintigraphie, Tomographie par émission de positons, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Emission tomography, Encephalon, Freezing, Motor nucleus, Nervous system diseases, Parkinson disease, Positron emission tomography, Subthalamic nucleus.

Abstract

Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [¹⁸F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 22`
A06				`@2 15`
A08	`01`	`1`	`ENG`	`@1 Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait`
A11	`01`	`1`		`@1 CHUL HYOUNG LYOO`
A11	`02`	`1`		`@1 AALTO (Sargo)`
A11	`03`	`1`		`@1 RINNE (Juha O.)`
A11	`04`	`1`		`@1 KI OOK LEE`
A11	`05`	`1`		`@1 SEUNG HUN OH`
A11	`06`	`1`		`@1 JIN WOO CHANG`
A11	`07`	`1`		`@1 MYUNG SIK LEE`
A14	`01`			`@1 Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine @2 Seoul @3 KOR @Z 1 aut. @Z 5 aut. @Z 7 aut.`
A14	`02`			`@1 Turku PET Center, University of Turku @2 Turku @3 FIN @Z 2 aut. @Z 3 aut.`
A14	`03`			`@1 Department of Neurology, Konyang University Hospital @2 Daejeon @3 KOR @Z 4 aut.`
A14	`04`			`@1 Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine @2 Seoul @3 KOR @Z 6 aut.`
A20				`@1 2176-2182`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000162671070060`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 47 ref.`
A47	`01`	`1`		`@0 08-0071402`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [¹⁸F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17C`
C02	`03`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Encéphale @5 09`
C03	`03`	`X`	`ENG`	`@0 Encephalon @5 09`
C03	`03`	`X`	`SPA`	`@0 Encéfalo @5 09`
C03	`04`	`X`	`FRE`	`@0 Noyau sousthalamique @5 10`
C03	`04`	`X`	`ENG`	`@0 Subthalamic nucleus @5 10`
C03	`04`	`X`	`SPA`	`@0 Núcleo subtalámico @5 10`
C03	`05`	`X`	`FRE`	`@0 Noyau moteur @5 11`
C03	`05`	`X`	`ENG`	`@0 Motor nucleus @5 11`
C03	`05`	`X`	`SPA`	`@0 Núcleo motor @5 11`
C03	`06`	`X`	`FRE`	`@0 Congélation @5 12`
C03	`06`	`X`	`ENG`	`@0 Freezing @5 12`
C03	`06`	`X`	`SPA`	`@0 Congelación @5 12`
C03	`07`	`X`	`FRE`	`@0 Tomoscintigraphie @5 13`
C03	`07`	`X`	`ENG`	`@0 Emission tomography @5 13`
C03	`07`	`X`	`SPA`	`@0 Tomocentelleografía @5 13`
C03	`08`	`X`	`FRE`	`@0 Tomographie par émission de positons @5 14`
C03	`08`	`X`	`ENG`	`@0 Positron emission tomography @5 14`
C03	`08`	`X`	`SPA`	`@0 Tomografía emisión positrones @5 14`
C03	`09`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`09`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Système nerveux central @5 37`
C07	`01`	`X`	`ENG`	`@0 Central nervous system @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso central @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
C07	`04`	`X`	`ENG`	`@0 Degenerative disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
N21				`@1 035`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0071402 INIST
ET :	Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait
AU :	CHUL HYOUNG LYOO; AALTO (Sargo); RINNE (Juha O.); KI OOK LEE; SEUNG HUN OH; JIN WOO CHANG; MYUNG SIK LEE
AF :	Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine/Seoul/Corée, République de (1 aut., 5 aut., 7 aut.); Turku PET Center, University of Turku/Turku/Finlande (2 aut., 3 aut.); Department of Neurology, Konyang University Hospital/Daejeon/Corée, République de (4 aut.); Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine/Seoul/Corée, République de (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 15; Pp. 2176-2182; Bibl. 47 ref.
LA :	Anglais
EA :	Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [¹⁸F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.
CC :	002B17; 002B17C; 002B17G
FD :	Pathologie du système nerveux; Maladie de Parkinson; Encéphale; Noyau sousthalamique; Noyau moteur; Congélation; Tomoscintigraphie; Tomographie par émission de positons; Stimulation cérébrale profonde
FG :	Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Nervous system diseases; Parkinson disease; Encephalon; Subthalamic nucleus; Motor nucleus; Freezing; Emission tomography; Positron emission tomography; Deep brain stimulation
EG :	Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Encéfalo; Núcleo subtalámico; Núcleo motor; Congelación; Tomocentelleografía; Tomografía emisión positrones
LO :	INIST-20953.354000162671070060
ID :	08-0071402

Links to Exploration step

Pascal:08-0071402

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait</title>
<author><name sortKey="Chul Hyoung Lyoo" sort="Chul Hyoung Lyoo" uniqKey="Chul Hyoung Lyoo" last="Chul Hyoung Lyoo">CHUL HYOUNG LYOO</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
<affiliation><inist:fA14 i1="02"><s1>Turku PET Center, University of Turku</s1>
<s2>Turku</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
<affiliation><inist:fA14 i1="02"><s1>Turku PET Center, University of Turku</s1>
<s2>Turku</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ki Ook Lee" sort="Ki Ook Lee" uniqKey="Ki Ook Lee" last="Ki Ook Lee">KI OOK LEE</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Konyang University Hospital</s1>
<s2>Daejeon</s2>
<s3>KOR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Seung Hun Oh" sort="Seung Hun Oh" uniqKey="Seung Hun Oh" last="Seung Hun Oh">SEUNG HUN OH</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jin Woo Chang" sort="Jin Woo Chang" uniqKey="Jin Woo Chang" last="Jin Woo Chang">JIN WOO CHANG</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Myung Sik Lee" sort="Myung Sik Lee" uniqKey="Myung Sik Lee" last="Myung Sik Lee">MYUNG SIK LEE</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0071402</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 08-0071402 INIST</idno>
<idno type="RBID">Pascal:08-0071402</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001459</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait</title>
<author><name sortKey="Chul Hyoung Lyoo" sort="Chul Hyoung Lyoo" uniqKey="Chul Hyoung Lyoo" last="Chul Hyoung Lyoo">CHUL HYOUNG LYOO</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
<affiliation><inist:fA14 i1="02"><s1>Turku PET Center, University of Turku</s1>
<s2>Turku</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
<affiliation><inist:fA14 i1="02"><s1>Turku PET Center, University of Turku</s1>
<s2>Turku</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ki Ook Lee" sort="Ki Ook Lee" uniqKey="Ki Ook Lee" last="Ki Ook Lee">KI OOK LEE</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Konyang University Hospital</s1>
<s2>Daejeon</s2>
<s3>KOR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Seung Hun Oh" sort="Seung Hun Oh" uniqKey="Seung Hun Oh" last="Seung Hun Oh">SEUNG HUN OH</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jin Woo Chang" sort="Jin Woo Chang" uniqKey="Jin Woo Chang" last="Jin Woo Chang">JIN WOO CHANG</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Myung Sik Lee" sort="Myung Sik Lee" uniqKey="Myung Sik Lee" last="Myung Sik Lee">MYUNG SIK LEE</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Emission tomography</term>
<term>Encephalon</term>
<term>Freezing</term>
<term>Motor nucleus</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Positron emission tomography</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du   système nerveux</term>
<term>Maladie de Parkinson</term>
<term>Encéphale</term>
<term>Noyau sousthalamique</term>
<term>Noyau moteur</term>
<term>Congélation</term>
<term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [<sup>18</sup>
F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>22</s2>
</fA05>
<fA06><s2>15</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>CHUL HYOUNG LYOO</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>AALTO (Sargo)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>RINNE (Juha O.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>KI OOK LEE</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>SEUNG HUN OH</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>JIN WOO CHANG</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>MYUNG SIK LEE</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Turku PET Center, University of Turku</s1>
<s2>Turku</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurology, Konyang University Hospital</s1>
<s2>Daejeon</s2>
<s3>KOR</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine</s1>
<s2>Seoul</s2>
<s3>KOR</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>2176-2182</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000162671070060</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>47 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>08-0071402</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [<sup>18</sup>
F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17C</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Subthalamic nucleus</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Núcleo subtalámico</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Noyau moteur</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Motor nucleus</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Núcleo motor</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Congélation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Freezing</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Congelación</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Tomoscintigraphie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Emission tomography</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Tomocentelleografía</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Tomographie par émission de positons</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Positron emission tomography</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Tomografía emisión positrones</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>035</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 08-0071402 INIST</NO>
<ET>Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait</ET>
<AU>CHUL HYOUNG LYOO; AALTO (Sargo); RINNE (Juha O.); KI OOK LEE; SEUNG HUN OH; JIN WOO CHANG; MYUNG SIK LEE</AU>
<AF>Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine/Seoul/Corée, République de (1 aut., 5 aut., 7 aut.); Turku PET Center, University of Turku/Turku/Finlande (2 aut., 3 aut.); Department of Neurology, Konyang University Hospital/Daejeon/Corée, République de (4 aut.); Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine/Seoul/Corée, République de (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 15; Pp. 2176-2182; Bibl. 47 ref.</SO>
<LA>Anglais</LA>
<EA>Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [<sup>18</sup>
F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.</EA>
<CC>002B17; 002B17C; 002B17G</CC>
<FD>Pathologie du   système nerveux; Maladie de Parkinson; Encéphale; Noyau sousthalamique; Noyau moteur; Congélation; Tomoscintigraphie; Tomographie par émission de positons; Stimulation cérébrale profonde</FD>
<FG>Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Nervous system diseases; Parkinson disease; Encephalon; Subthalamic nucleus; Motor nucleus; Freezing; Emission tomography; Positron emission tomography; Deep brain stimulation</ED>
<EG>Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Encéfalo; Núcleo subtalámico; Núcleo motor; Congelación; Tomocentelleografía; Tomografía emisión positrones</SD>
<LO>INIST-20953.354000162671070060</LO>
<ID>08-0071402</ID>
</server>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001459 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001459 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:08-0071402
   |texte=   Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait

Different Cerebral Cortical Areas Influence the Effect of Subthalamic Nucleus Stimulation on Parkinsonian Motor Deficits and Freezing of Gait

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri