MovDisordV3, PascalFrancis, Corpus, bibRecord, 001443

A Unique Case of Coincidence of Early Onset Parkinson's Disease and Multiple Sclerosis

Identifieur interne : 001443 ( PascalFrancis/Corpus ); précédent : 001442; suivant : 001444

A Unique Case of Coincidence of Early Onset Parkinson's Disease and Multiple Sclerosis

Auteurs : Peter Valkovic ; Georgi Krastev ; Miroslav Mako ; Petra Leitner ; Thomas Gasser

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0071418

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Maladie de Parkinson, Sclérose en plaques.

English descriptors

KwdEn :
- Multiple sclerosis, Nervous system diseases, Parkinson disease.

Abstract

We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to tri-hexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 22`
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A08	`01`	`1`	`ENG`	`@1 A Unique Case of Coincidence of Early Onset Parkinson's Disease and Multiple Sclerosis`
A11	`01`	`1`		`@1 VALKOVIC (Peter)`
A11	`02`	`1`		`@1 KRASTEV (Georgi)`
A11	`03`	`1`		`@1 MAKO (Miroslav)`
A11	`04`	`1`		`@1 LEITNER (Petra)`
A11	`05`	`1`		`@1 GASSER (Thomas)`
A14	`01`			`@1 Department of Neurology, Trnavian University Hospital @2 Trnava @3 SVK @Z 1 aut. @Z 2 aut. @Z 3 aut.`
A14	`02`			`@1 2nd Department of Neurology, School of Medicine, Comenius University @2 Bratislava @3 SVK @Z 1 aut.`
A14	`03`			`@1 Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen @2 Tübingen @3 DEU @Z 4 aut. @Z 5 aut.`
A20				`@1 2278-2281`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000162671070220`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 08-0071418`
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C01	`01`		`ENG`	@0 We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to tri-hexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.
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C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
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C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Sclérose en plaques @2 NM @5 03`
C03	`03`	`X`	`ENG`	`@0 Multiple sclerosis @2 NM @5 03`
C03	`03`	`X`	`SPA`	`@0 Esclerosis en placa @2 NM @5 03`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie inflammatoire @5 42`
C07	`05`	`X`	`ENG`	`@0 Inflammatory disease @5 42`
C07	`05`	`X`	`SPA`	`@0 Enfermedad inflamatoria @5 42`
N21				`@1 035`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0071418 INIST
ET :	A Unique Case of Coincidence of Early Onset Parkinson's Disease and Multiple Sclerosis
AU :	VALKOVIC (Peter); KRASTEV (Georgi); MAKO (Miroslav); LEITNER (Petra); GASSER (Thomas)
AF :	Department of Neurology, Trnavian University Hospital/Trnava/Slovaquie (1 aut., 2 aut., 3 aut.); 2nd Department of Neurology, School of Medicine, Comenius University/Bratislava/Slovaquie (1 aut.); Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (4 aut., 5 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 15; Pp. 2278-2281; Bibl. 15 ref.
LA :	Anglais
EA :	We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to tri-hexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.
CC :	002B17; 002B17F; 002B17G
FD :	Pathologie du système nerveux; Maladie de Parkinson; Sclérose en plaques
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Maladie inflammatoire
ED :	Nervous system diseases; Parkinson disease; Multiple sclerosis
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Inflammatory disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Esclerosis en placa
LO :	INIST-20953.354000162671070220
ID :	08-0071418

Links to Exploration step

Pascal:08-0071418

Le document en format XML

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<front><div type="abstract" xml:lang="en">We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to tri-hexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.</div>
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<fC01 i1="01" l="ENG"><s0>We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to tri-hexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.</s0>
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<server><NO>PASCAL 08-0071418 INIST</NO>
<ET>A Unique Case of Coincidence of Early Onset Parkinson's Disease and Multiple Sclerosis</ET>
<AU>VALKOVIC (Peter); KRASTEV (Georgi); MAKO (Miroslav); LEITNER (Petra); GASSER (Thomas)</AU>
<AF>Department of Neurology, Trnavian University Hospital/Trnava/Slovaquie (1 aut., 2 aut., 3 aut.); 2nd Department of Neurology, School of Medicine, Comenius University/Bratislava/Slovaquie (1 aut.); Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (4 aut., 5 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 15; Pp. 2278-2281; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to tri-hexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug-induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30.</EA>
<CC>002B17; 002B17F; 002B17G</CC>
<FD>Pathologie du   système nerveux; Maladie de Parkinson; Sclérose en plaques</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Maladie inflammatoire</FG>
<ED>Nervous system diseases; Parkinson disease; Multiple sclerosis</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Inflammatory disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Esclerosis en placa</SD>
<LO>INIST-20953.354000162671070220</LO>
<ID>08-0071418</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A Unique Case of Coincidence of Early Onset Parkinson's Disease and Multiple Sclerosis

A Unique Case of Coincidence of Early Onset Parkinson's Disease and Multiple Sclerosis

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