MovDisordV3, PascalFrancis, Corpus, bibRecord, 001382

Paroxysmal Dyskinesias in Mice

Identifieur interne : 001382 ( PascalFrancis/Corpus ); précédent : 001381; suivant : 001383

Paroxysmal Dyskinesias in Mice

Auteurs : Thomas L. Shirley ; Lekha M. Rao ; Ellen J. Hess ; H. A. Jinnah

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0133670

Descripteurs français

Pascal (Inist)
- Dyskinésie, Dystonie, Pathologie du système nerveux, Animal, Souris.

English descriptors

KwdEn :
- Animal, Dyskinesia, Dystonia, Mouse, Nervous system diseases.

Abstract

Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A05				`@2 23`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Paroxysmal Dyskinesias in Mice`
A11	`01`	`1`		`@1 SHIRLEY (Thomas L.)`
A11	`02`	`1`		`@1 RAO (Lekha M.)`
A11	`03`	`1`		`@1 HESS (Ellen J.)`
A11	`04`	`1`		`@1 JINNAH (H. A.)`
A14	`01`			`@1 Department of Neurology, Johns Hopkins University @2 Baltimore, Maryland @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A20				`@1 259-264`
A21				`@1 2008`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000175066510160`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 38 ref.`
A47	`01`	`1`		`@0 08-0133670`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B02U01`
C03	`01`	`X`	`FRE`	`@0 Dyskinésie @5 01`
C03	`01`	`X`	`ENG`	`@0 Dyskinesia @5 01`
C03	`01`	`X`	`SPA`	`@0 Disquinesia @5 01`
C03	`02`	`X`	`FRE`	`@0 Dystonie @5 02`
C03	`02`	`X`	`ENG`	`@0 Dystonia @5 02`
C03	`02`	`X`	`SPA`	`@0 Distonía @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Animal @5 09`
C03	`04`	`X`	`ENG`	`@0 Animal @5 09`
C03	`04`	`X`	`SPA`	`@0 Animal @5 09`
C03	`05`	`X`	`FRE`	`@0 Souris @5 10`
C03	`05`	`X`	`ENG`	`@0 Mouse @5 10`
C03	`05`	`X`	`SPA`	`@0 Ratón @5 10`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 37`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 37`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 37`
C07	`05`	`X`	`FRE`	`@0 Mouvement involontaire @5 38`
C07	`05`	`X`	`ENG`	`@0 Involuntary movement @5 38`
C07	`05`	`X`	`SPA`	`@0 Movimiento involuntario @5 38`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 40`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 40`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 40`
C07	`07`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 41`
C07	`07`	`X`	`ENG`	`@0 Striated muscle disease @5 41`
C07	`07`	`X`	`SPA`	`@0 Músculo estriado patología @5 41`
C07	`08`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 42`
C07	`08`	`X`	`ENG`	`@0 Cerebral disorder @5 42`
C07	`08`	`X`	`SPA`	`@0 Encéfalo patología @5 42`
C07	`09`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 43`
C07	`09`	`X`	`ENG`	`@0 Central nervous system disease @5 43`
C07	`09`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 43`
N21				`@1 077`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0133670 INIST
ET :	Paroxysmal Dyskinesias in Mice
AU :	SHIRLEY (Thomas L.); RAO (Lekha M.); HESS (Ellen J.); JINNAH (H. A.)
AF :	Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 2; Pp. 259-264; Bibl. 38 ref.
LA :	Anglais
EA :	Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.
CC :	002B17; 002B02U01
FD :	Dyskinésie; Dystonie; Pathologie du système nerveux; Animal; Souris
FG :	Rodentia; Mammalia; Vertebrata; Syndrome extrapyramidal; Mouvement involontaire; Trouble neurologique; Pathologie du muscle strié; Pathologie de l'encéphale; Pathologie du système nerveux central
ED :	Dyskinesia; Dystonia; Nervous system diseases; Animal; Mouse
EG :	Rodentia; Mammalia; Vertebrata; Extrapyramidal syndrome; Involuntary movement; Neurological disorder; Striated muscle disease; Cerebral disorder; Central nervous system disease
SD :	Disquinesia; Distonía; Sistema nervioso patología; Animal; Ratón
LO :	INIST-20953.354000175066510160
ID :	08-0133670

Links to Exploration step

Pascal:08-0133670

Le document en format XML

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<front><div type="abstract" xml:lang="en">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.</div>
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<fC07 i1="09" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>43</s5>
</fC07>
<fN21><s1>077</s1>
</fN21>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 08-0133670 INIST</NO>
<ET>Paroxysmal Dyskinesias in Mice</ET>
<AU>SHIRLEY (Thomas L.); RAO (Lekha M.); HESS (Ellen J.); JINNAH (H. A.)</AU>
<AF>Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 2; Pp. 259-264; Bibl. 38 ref.</SO>
<LA>Anglais</LA>
<EA>Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.</EA>
<CC>002B17; 002B02U01</CC>
<FD>Dyskinésie; Dystonie; Pathologie du   système nerveux; Animal; Souris</FD>
<FG>Rodentia; Mammalia; Vertebrata; Syndrome extrapyramidal; Mouvement involontaire; Trouble neurologique; Pathologie du muscle strié; Pathologie de l'encéphale; Pathologie du   système nerveux central</FG>
<ED>Dyskinesia; Dystonia; Nervous system diseases; Animal; Mouse</ED>
<EG>Rodentia; Mammalia; Vertebrata; Extrapyramidal syndrome; Involuntary movement; Neurological disorder; Striated muscle disease; Cerebral disorder; Central nervous system disease</EG>
<SD>Disquinesia; Distonía; Sistema nervioso patología; Animal; Ratón</SD>
<LO>INIST-20953.354000175066510160</LO>
<ID>08-0133670</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Paroxysmal Dyskinesias in Mice

Paroxysmal Dyskinesias in Mice

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