Movement Disorders (revue)

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Decision Making in Parkinson's Disease : Analysis of Behavioral and Physiological Patterns in the Iowa Gambling Task

Identifieur interne : 001319 ( PascalFrancis/Corpus ); précédent : 001318; suivant : 001320

Decision Making in Parkinson's Disease : Analysis of Behavioral and Physiological Patterns in the Iowa Gambling Task

Auteurs : Mutsutaka Kobayakawa ; Shinichi Koyama ; Masaru Mimura ; Mitsuru Kawamura

Source :

RBID : Pascal:08-0199273

Descripteurs français

English descriptors

Abstract

Recent studies suggest that social recognition processes are affected by Parkinson's disease (PD). However, whether PD patients exhibit behavioral changes is still controversial. The purpose of the present study was to examine the decision making of PD patients performing the Iowa Gambling Task (IGT). We recruited a large number of early, nondemented PD patients for the IGT. We also recorded the skin conductance responses (SCRs) during the task as a measure of emotional arousal. Compared with the normal control (NC) subjects, PD patients selected more disadvantageous decks in the IGT, and their SCRs were lower than those of NC subjects before making decisions and after receiving reward or punishment. The tendency toward risky choices was not correlated with age, education, global cognitive function, or the severity of the disease. These results confirmed that the decision making of PD patients was affected by the disease, rather than by other cognitive functions; moreover, such behavior was related to lower emotional responses. Behavioral and SCR patterns of PD patients were similar to those of amygdala-damaged patients. The response bias toward risky choices in PD may be explained by the dysfunction of the amygdala, which is known to be involved in risk evaluation.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03   1    @0 Mov. disord.
A05       @2 23
A06       @2 4
A08 01  1  ENG  @1 Decision Making in Parkinson's Disease : Analysis of Behavioral and Physiological Patterns in the Iowa Gambling Task
A11 01  1    @1 KOBAYAKAWA (Mutsutaka)
A11 02  1    @1 KOYAMA (Shinichi)
A11 03  1    @1 MIMURA (Masaru)
A11 04  1    @1 KAWAMURA (Mitsuru)
A14 01      @1 Department of Neurology, Showa University School of Medicine @2 Tokyo @3 JPN @Z 1 aut. @Z 2 aut. @Z 4 aut.
A14 02      @1 Design Psychology Unit, Department of Design Science, Graduate School of Engineering, Chiba University @2 Chiba @3 JPN @Z 2 aut.
A14 03      @1 Department of Neuropsychiatry, Showa University School of Medicine @2 Tokyo @3 JPN @Z 3 aut.
A14 04      @1 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST) @2 Saitama @3 JPN @Z 4 aut.
A20       @1 547-552
A21       @1 2008
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000183361080090
A44       @0 0000 @1 © 2008 INIST-CNRS. All rights reserved.
A45       @0 35 ref.
A47 01  1    @0 08-0199273
A60       @1 P
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 Recent studies suggest that social recognition processes are affected by Parkinson's disease (PD). However, whether PD patients exhibit behavioral changes is still controversial. The purpose of the present study was to examine the decision making of PD patients performing the Iowa Gambling Task (IGT). We recruited a large number of early, nondemented PD patients for the IGT. We also recorded the skin conductance responses (SCRs) during the task as a measure of emotional arousal. Compared with the normal control (NC) subjects, PD patients selected more disadvantageous decks in the IGT, and their SCRs were lower than those of NC subjects before making decisions and after receiving reward or punishment. The tendency toward risky choices was not correlated with age, education, global cognitive function, or the severity of the disease. These results confirmed that the decision making of PD patients was affected by the disease, rather than by other cognitive functions; moreover, such behavior was related to lower emotional responses. Behavioral and SCR patterns of PD patients were similar to those of amygdala-damaged patients. The response bias toward risky choices in PD may be explained by the dysfunction of the amygdala, which is known to be involved in risk evaluation.
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C03 01  X  FRE  @0 Maladie de Parkinson @2 NM @5 01
C03 01  X  ENG  @0 Parkinson disease @2 NM @5 01
C03 01  X  SPA  @0 Parkinson enfermedad @2 NM @5 01
C03 02  X  FRE  @0 Pathologie du système nerveux @5 02
C03 02  X  ENG  @0 Nervous system diseases @5 02
C03 02  X  SPA  @0 Sistema nervioso patología @5 02
C03 03  X  FRE  @0 Prise de décision @5 09
C03 03  X  ENG  @0 Decision making @5 09
C03 03  X  SPA  @0 Toma decision @5 09
C03 04  X  FRE  @0 Analyse comportementale @5 10
C03 04  X  ENG  @0 Behavioral analysis @5 10
C03 04  X  SPA  @0 Análisis conductual @5 10
C03 05  X  FRE  @0 Peau @5 11
C03 05  X  ENG  @0 Skin @5 11
C03 05  X  SPA  @0 Piel @5 11
C03 06  X  FRE  @0 Cognition @5 12
C03 06  X  ENG  @0 Cognition @5 12
C03 06  X  SPA  @0 Cognición @5 12
C07 01  X  FRE  @0 Pathologie de l'encéphale @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Syndrome extrapyramidal @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 126
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 08-0199273 INIST
ET : Decision Making in Parkinson's Disease : Analysis of Behavioral and Physiological Patterns in the Iowa Gambling Task
AU : KOBAYAKAWA (Mutsutaka); KOYAMA (Shinichi); MIMURA (Masaru); KAWAMURA (Mitsuru)
AF : Department of Neurology, Showa University School of Medicine/Tokyo/Japon (1 aut., 2 aut., 4 aut.); Design Psychology Unit, Department of Design Science, Graduate School of Engineering, Chiba University/Chiba/Japon (2 aut.); Department of Neuropsychiatry, Showa University School of Medicine/Tokyo/Japon (3 aut.); Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST)/Saitama/Japon (4 aut.)
DT : Publication en série; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 4; Pp. 547-552; Bibl. 35 ref.
LA : Anglais
EA : Recent studies suggest that social recognition processes are affected by Parkinson's disease (PD). However, whether PD patients exhibit behavioral changes is still controversial. The purpose of the present study was to examine the decision making of PD patients performing the Iowa Gambling Task (IGT). We recruited a large number of early, nondemented PD patients for the IGT. We also recorded the skin conductance responses (SCRs) during the task as a measure of emotional arousal. Compared with the normal control (NC) subjects, PD patients selected more disadvantageous decks in the IGT, and their SCRs were lower than those of NC subjects before making decisions and after receiving reward or punishment. The tendency toward risky choices was not correlated with age, education, global cognitive function, or the severity of the disease. These results confirmed that the decision making of PD patients was affected by the disease, rather than by other cognitive functions; moreover, such behavior was related to lower emotional responses. Behavioral and SCR patterns of PD patients were similar to those of amygdala-damaged patients. The response bias toward risky choices in PD may be explained by the dysfunction of the amygdala, which is known to be involved in risk evaluation.
CC : 002B17; 002B17G
FD : Maladie de Parkinson; Pathologie du système nerveux; Prise de décision; Analyse comportementale; Peau; Cognition
FG : Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED : Parkinson disease; Nervous system diseases; Decision making; Behavioral analysis; Skin; Cognition
EG : Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD : Parkinson enfermedad; Sistema nervioso patología; Toma decision; Análisis conductual; Piel; Cognición
LO : INIST-20953.354000183361080090
ID : 08-0199273

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Pascal:08-0199273

Le document en format XML

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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21>
<s1>126</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
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<NO>PASCAL 08-0199273 INIST</NO>
<ET>Decision Making in Parkinson's Disease : Analysis of Behavioral and Physiological Patterns in the Iowa Gambling Task</ET>
<AU>KOBAYAKAWA (Mutsutaka); KOYAMA (Shinichi); MIMURA (Masaru); KAWAMURA (Mitsuru)</AU>
<AF>Department of Neurology, Showa University School of Medicine/Tokyo/Japon (1 aut., 2 aut., 4 aut.); Design Psychology Unit, Department of Design Science, Graduate School of Engineering, Chiba University/Chiba/Japon (2 aut.); Department of Neuropsychiatry, Showa University School of Medicine/Tokyo/Japon (3 aut.); Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST)/Saitama/Japon (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 4; Pp. 547-552; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Recent studies suggest that social recognition processes are affected by Parkinson's disease (PD). However, whether PD patients exhibit behavioral changes is still controversial. The purpose of the present study was to examine the decision making of PD patients performing the Iowa Gambling Task (IGT). We recruited a large number of early, nondemented PD patients for the IGT. We also recorded the skin conductance responses (SCRs) during the task as a measure of emotional arousal. Compared with the normal control (NC) subjects, PD patients selected more disadvantageous decks in the IGT, and their SCRs were lower than those of NC subjects before making decisions and after receiving reward or punishment. The tendency toward risky choices was not correlated with age, education, global cognitive function, or the severity of the disease. These results confirmed that the decision making of PD patients was affected by the disease, rather than by other cognitive functions; moreover, such behavior was related to lower emotional responses. Behavioral and SCR patterns of PD patients were similar to those of amygdala-damaged patients. The response bias toward risky choices in PD may be explained by the dysfunction of the amygdala, which is known to be involved in risk evaluation.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Prise de décision; Analyse comportementale; Peau; Cognition</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Decision making; Behavioral analysis; Skin; Cognition</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Toma decision; Análisis conductual; Piel; Cognición</SD>
<LO>INIST-20953.354000183361080090</LO>
<ID>08-0199273</ID>
</server>
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