MovDisordV3, PascalFrancis, Corpus, bibRecord, 001315

Mild Parkinsonian Signs Are Associated with Lower Olfactory Test Scores in the Community-Dwelling Elderly

Identifieur interne : 001315 ( PascalFrancis/Corpus ); précédent : 001314; suivant : 001316

Mild Parkinsonian Signs Are Associated with Lower Olfactory Test Scores in the Community-Dwelling Elderly

Auteurs : Elan D. Louis ; Karen Marder ; Matthias H. Tabert ; Devangere P. Devanand

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0199287

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Signe, Test score, Personne âgée, Olfaction, Epidémiologie.

English descriptors

KwdEn :
- Elderly, Epidemiology, Nervous system diseases, Olfaction, Parkinson disease, Score test, Sign.

Abstract

Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community-dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights-Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40-item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT -41]) indicated greater olfactory dysfunction. One-hundred-seventy-seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3±7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04-1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor). MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C03	`04`	`X`	`ENG`	`@0 Score test @5 10`
C03	`05`	`X`	`FRE`	`@0 Personne âgée @5 11`
C03	`05`	`X`	`ENG`	`@0 Elderly @5 11`
C03	`05`	`X`	`SPA`	`@0 Anciano @5 11`
C03	`06`	`X`	`FRE`	`@0 Olfaction @5 12`
C03	`06`	`X`	`ENG`	`@0 Olfaction @5 12`
C03	`06`	`X`	`SPA`	`@0 Olfación @5 12`
C03	`07`	`X`	`FRE`	`@0 Epidémiologie @5 13`
C03	`07`	`X`	`ENG`	`@0 Epidemiology @5 13`
C03	`07`	`X`	`SPA`	`@0 Epidemiología @5 13`
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C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
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Format Inist (serveur)

NO :	PASCAL 08-0199287 INIST
ET :	Mild Parkinsonian Signs Are Associated with Lower Olfactory Test Scores in the Community-Dwelling Elderly
AU :	LOUIS (Elan D.); MARDER (Karen); TABERT (Matthias H.); DEVANAND (Devangere P.)
AF :	The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut.); Taub Institute for Research of Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut.); Department of Epidemiology, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Geriatric Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut.); New York State Psychiatric Institute/New York, New York/Etats-Unis (3 aut., 4 aut.); Department of Biological Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 4; Pp. 524-530; Bibl. 34 ref.
LA :	Anglais
EA :	Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community-dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights-Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40-item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT -41]) indicated greater olfactory dysfunction. One-hundred-seventy-seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3±7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04-1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor). MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Signe; Test score; Personne âgée; Olfaction; Epidémiologie
FG :	Homme; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Sign; Score test; Elderly; Olfaction; Epidemiology
EG :	Human; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Signo; Anciano; Olfación; Epidemiología
LO :	INIST-20953.354000183361080060
ID :	08-0199287

Links to Exploration step

Pascal:08-0199287

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Mild Parkinsonian Signs Are Associated with Lower Olfactory Test Scores in the Community-Dwelling Elderly</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Elderly</term>
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<term>Score test</term>
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</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Signe</term>
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<front><div type="abstract" xml:lang="en">Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community-dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights-Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40-item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT -41]) indicated greater olfactory dysfunction. One-hundred-seventy-seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3±7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04-1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor). MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies.</div>
</front>
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<fA11 i1="01" i2="1"><s1>LOUIS (Elan D.)</s1>
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<sZ>1 aut.</sZ>
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<sZ>3 aut.</sZ>
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<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Biological Psychiatry, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
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<s5>11</s5>
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<s5>37</s5>
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<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
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<s5>39</s5>
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<s5>39</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
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<server><NO>PASCAL 08-0199287 INIST</NO>
<ET>Mild Parkinsonian Signs Are Associated with Lower Olfactory Test Scores in the Community-Dwelling Elderly</ET>
<AU>LOUIS (Elan D.); MARDER (Karen); TABERT (Matthias H.); DEVANAND (Devangere P.)</AU>
<AF>The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut.); Taub Institute for Research of Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut.); Department of Epidemiology, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Geriatric Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut.); New York State Psychiatric Institute/New York, New York/Etats-Unis (3 aut., 4 aut.); Department of Biological Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 4; Pp. 524-530; Bibl. 34 ref.</SO>
<LA>Anglais</LA>
<EA>Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community-dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights-Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40-item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT -41]) indicated greater olfactory dysfunction. One-hundred-seventy-seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3±7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04-1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor). MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Signe; Test score; Personne âgée; Olfaction; Epidémiologie</FD>
<FG>Homme; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Sign; Score test; Elderly; Olfaction; Epidemiology</ED>
<EG>Human; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Signo; Anciano; Olfación; Epidemiología</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Mild Parkinsonian Signs Are Associated with Lower Olfactory Test Scores in the Community-Dwelling Elderly

Mild Parkinsonian Signs Are Associated with Lower Olfactory Test Scores in the Community-Dwelling Elderly

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