MovDisordV3, PascalFrancis, Corpus, bibRecord, 001150

Cut-Off Score of the Mattis Dementia Rating Scale for Screening Dementia in Parkinson's Disease

Identifieur interne : 001150 ( PascalFrancis/Corpus ); précédent : 001149; suivant : 001151

Cut-Off Score of the Mattis Dementia Rating Scale for Screening Dementia in Parkinson's Disease

Auteurs : Gisela Llebaria ; Javier Pagonabarraga ; Jaime Kulisevsky ; Carmen Garcia-Sanchez ; Berta Pascual-Sedano ; Alexandre Gironell ; Mercè Martinez-Corral

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0450245

Descripteurs français

Pascal (Inist)
- Démence, Maladie de Parkinson, Pathologie du système nerveux, Dementia Rating Scale Mattis, Dépistage.

English descriptors

KwdEn :
- Dementia, Dementia Rating Scale Mattis, Medical screening, Nervous system diseases, Parkinson disease.

Abstract

The prevalence of dementia in Parkinson's disease (PD) is close to 30%, and its incidence is 4 to 6 times higher than in age-matched general population. PD with dementia (PDD) is mainly characterized by a predominant and progressive frontal-subcortical impairment. The Mattis Dementia Rating Scale (MDRS) is a commonly used screening test that sensitively measures the degree of frontal-subcortical defects. Although the MDRS has been validated as a screening test of cognitive dysfunction in nondemented PD patients (PD-ND), its utility for screening dementia in PD is unknown. In order to validate the MDRS for diagnosis of PDD it was prospectively administered to 92 PD patients (57 PD-ND, 35 PDD) fulfilling UK-PDSBB criteria. Dementia was diagnosed according to DSM-IV-TR and a Clinical Dementia Rating (CDR) scale score ≥1. Univariate, logistic regression, and ROC curve analysis were carried out to measure the discriminative power of MDRS in PDD. Regression analysis showed MDRS total scores to independently differentiate PD-ND from PDD (P < 0.001). Age and education did not predict the presence of dementia. ROC curve analysis showed a cut-off score of ≤123 on the MDRS total scores to yield high sensitivity (92.65%), specificity (91.4%), positive and negative predictive values (PPV 83.3%, NPV 96.4%). A brief version of the MDRS obtained by the addition of the memory, initiation/perseveration, and conceptualization subscores yielded similar discriminant properties. The MDRS has an excellent discriminant ability to diagnose dementia in PD and provides an objective measure to distinguish PD-ND from PDD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 The prevalence of dementia in Parkinson's disease (PD) is close to 30%, and its incidence is 4 to 6 times higher than in age-matched general population. PD with dementia (PDD) is mainly characterized by a predominant and progressive frontal-subcortical impairment. The Mattis Dementia Rating Scale (MDRS) is a commonly used screening test that sensitively measures the degree of frontal-subcortical defects. Although the MDRS has been validated as a screening test of cognitive dysfunction in nondemented PD patients (PD-ND), its utility for screening dementia in PD is unknown. In order to validate the MDRS for diagnosis of PDD it was prospectively administered to 92 PD patients (57 PD-ND, 35 PDD) fulfilling UK-PDSBB criteria. Dementia was diagnosed according to DSM-IV-TR and a Clinical Dementia Rating (CDR) scale score ≥1. Univariate, logistic regression, and ROC curve analysis were carried out to measure the discriminative power of MDRS in PDD. Regression analysis showed MDRS total scores to independently differentiate PD-ND from PDD (P < 0.001). Age and education did not predict the presence of dementia. ROC curve analysis showed a cut-off score of ≤123 on the MDRS total scores to yield high sensitivity (92.65%), specificity (91.4%), positive and negative predictive values (PPV 83.3%, NPV 96.4%). A brief version of the MDRS obtained by the addition of the memory, initiation/perseveration, and conceptualization subscores yielded similar discriminant properties. The MDRS has an excellent discriminant ability to diagnose dementia in PD and provides an objective measure to distinguish PD-ND from PDD.
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C03	`04`	`X`	`SPA`	`@0 Dementia Rating Scale Mattis @2 NP @5 09`
C03	`05`	`X`	`FRE`	`@0 Dépistage @5 10`
C03	`05`	`X`	`ENG`	`@0 Medical screening @5 10`
C03	`05`	`X`	`SPA`	`@0 Descubrimiento @5 10`
C07	`01`	`X`	`FRE`	`@0 Maladie dégénérative @5 37`
C07	`01`	`X`	`ENG`	`@0 Degenerative disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
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C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
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Format Inist (serveur)

NO :	PASCAL 08-0450245 INIST
ET :	Cut-Off Score of the Mattis Dementia Rating Scale for Screening Dementia in Parkinson's Disease
AU :	LLEBARIA (Gisela); PAGONABARRAGA (Javier); KULISEVSKY (Jaime); GARCIA-SANCHEZ (Carmen); PASCUAL-SEDANO (Berta); GIRONELL (Alexandre); MARTINEZ-CORRAL (Mercè)
AF :	Movement Disorders Unit, Neurology Department, Sant Pan Hospital, Autonomous University of Barcelona and CIBERNED (Centro de Investigaciones Biome'dicas en Red -Enfermedades Neurodegenerativas)/Barcelona/Espagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 11; Pp. 1546-1550; Bibl. 24 ref.
LA :	Anglais
EA :	The prevalence of dementia in Parkinson's disease (PD) is close to 30%, and its incidence is 4 to 6 times higher than in age-matched general population. PD with dementia (PDD) is mainly characterized by a predominant and progressive frontal-subcortical impairment. The Mattis Dementia Rating Scale (MDRS) is a commonly used screening test that sensitively measures the degree of frontal-subcortical defects. Although the MDRS has been validated as a screening test of cognitive dysfunction in nondemented PD patients (PD-ND), its utility for screening dementia in PD is unknown. In order to validate the MDRS for diagnosis of PDD it was prospectively administered to 92 PD patients (57 PD-ND, 35 PDD) fulfilling UK-PDSBB criteria. Dementia was diagnosed according to DSM-IV-TR and a Clinical Dementia Rating (CDR) scale score ≥1. Univariate, logistic regression, and ROC curve analysis were carried out to measure the discriminative power of MDRS in PDD. Regression analysis showed MDRS total scores to independently differentiate PD-ND from PDD (P < 0.001). Age and education did not predict the presence of dementia. ROC curve analysis showed a cut-off score of ≤123 on the MDRS total scores to yield high sensitivity (92.65%), specificity (91.4%), positive and negative predictive values (PPV 83.3%, NPV 96.4%). A brief version of the MDRS obtained by the addition of the memory, initiation/perseveration, and conceptualization subscores yielded similar discriminant properties. The MDRS has an excellent discriminant ability to diagnose dementia in PD and provides an objective measure to distinguish PD-ND from PDD.
CC :	002B17; 002B17G
FD :	Démence; Maladie de Parkinson; Pathologie du système nerveux; Dementia Rating Scale Mattis; Dépistage
FG :	Maladie dégénérative; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central
ED :	Dementia; Parkinson disease; Nervous system diseases; Dementia Rating Scale Mattis; Medical screening
EG :	Degenerative disease; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease
SD :	Demencia; Parkinson enfermedad; Sistema nervioso patología; Dementia Rating Scale Mattis; Descubrimiento
LO :	INIST-20953.354000185584200070
ID :	08-0450245

Links to Exploration step

Pascal:08-0450245

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term>
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<term>Parkinson disease</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Démence</term>
<term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">The prevalence of dementia in Parkinson's disease (PD) is close to 30%, and its incidence is 4 to 6 times higher than in age-matched general population. PD with dementia (PDD) is mainly characterized by a predominant and progressive frontal-subcortical impairment. The Mattis Dementia Rating Scale (MDRS) is a commonly used screening test that sensitively measures the degree of frontal-subcortical defects. Although the MDRS has been validated as a screening test of cognitive dysfunction in nondemented PD patients (PD-ND), its utility for screening dementia in PD is unknown. In order to validate the MDRS for diagnosis of PDD it was prospectively administered to 92 PD patients (57 PD-ND, 35 PDD) fulfilling UK-PDSBB criteria. Dementia was diagnosed according to DSM-IV-TR and a Clinical Dementia Rating (CDR) scale score ≥1. Univariate, logistic regression, and ROC curve analysis were carried out to measure the discriminative power of MDRS in PDD. Regression analysis showed MDRS total scores to independently differentiate PD-ND from PDD (P < 0.001). Age and education did not predict the presence of dementia. ROC curve analysis showed a cut-off score of ≤123 on the MDRS total scores to yield high sensitivity (92.65%), specificity (91.4%), positive and negative predictive values (PPV 83.3%, NPV 96.4%). A brief version of the MDRS obtained by the addition of the memory, initiation/perseveration, and conceptualization subscores yielded similar discriminant properties. The MDRS has an excellent discriminant ability to diagnose dementia in PD and provides an objective measure to distinguish PD-ND from PDD.</div>
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<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<s5>40</s5>
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<server><NO>PASCAL 08-0450245 INIST</NO>
<ET>Cut-Off Score of the Mattis Dementia Rating Scale for Screening Dementia in Parkinson's Disease</ET>
<AU>LLEBARIA (Gisela); PAGONABARRAGA (Javier); KULISEVSKY (Jaime); GARCIA-SANCHEZ (Carmen); PASCUAL-SEDANO (Berta); GIRONELL (Alexandre); MARTINEZ-CORRAL (Mercè)</AU>
<AF>Movement Disorders Unit, Neurology Department, Sant Pan Hospital, Autonomous University of Barcelona and CIBERNED (Centro de Investigaciones Biome'dicas en Red -Enfermedades Neurodegenerativas)/Barcelona/Espagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 11; Pp. 1546-1550; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>The prevalence of dementia in Parkinson's disease (PD) is close to 30%, and its incidence is 4 to 6 times higher than in age-matched general population. PD with dementia (PDD) is mainly characterized by a predominant and progressive frontal-subcortical impairment. The Mattis Dementia Rating Scale (MDRS) is a commonly used screening test that sensitively measures the degree of frontal-subcortical defects. Although the MDRS has been validated as a screening test of cognitive dysfunction in nondemented PD patients (PD-ND), its utility for screening dementia in PD is unknown. In order to validate the MDRS for diagnosis of PDD it was prospectively administered to 92 PD patients (57 PD-ND, 35 PDD) fulfilling UK-PDSBB criteria. Dementia was diagnosed according to DSM-IV-TR and a Clinical Dementia Rating (CDR) scale score ≥1. Univariate, logistic regression, and ROC curve analysis were carried out to measure the discriminative power of MDRS in PDD. Regression analysis showed MDRS total scores to independently differentiate PD-ND from PDD (P < 0.001). Age and education did not predict the presence of dementia. ROC curve analysis showed a cut-off score of ≤123 on the MDRS total scores to yield high sensitivity (92.65%), specificity (91.4%), positive and negative predictive values (PPV 83.3%, NPV 96.4%). A brief version of the MDRS obtained by the addition of the memory, initiation/perseveration, and conceptualization subscores yielded similar discriminant properties. The MDRS has an excellent discriminant ability to diagnose dementia in PD and provides an objective measure to distinguish PD-ND from PDD.</EA>
<CC>002B17; 002B17G</CC>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Cut-Off Score of the Mattis Dementia Rating Scale for Screening Dementia in Parkinson's Disease

Cut-Off Score of the Mattis Dementia Rating Scale for Screening Dementia in Parkinson's Disease

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