The History of Dopamine and Levodopa in the Treatment of Parkinson's Disease
Identifieur interne : 001136 ( PascalFrancis/Corpus ); précédent : 001135; suivant : 001137The History of Dopamine and Levodopa in the Treatment of Parkinson's Disease
Auteurs : Stanley FahnSource :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 08-0466142 INIST |
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ET : | The History of Dopamine and Levodopa in the Treatment of Parkinson's Disease |
AU : | FAHN (Stanley); OLANOW (C. Warren); LEES (Andrew); OBESO (Jose) |
AF : | Columbia University/New York/Etats-Unis (1 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, New York/Etats-Unis (1 aut.); Department of Neurology, Reta Lila Institute of Neurological Studies/London/Royaume-Uni (2 aut.); Department of Neurology, University of Navarra/Pamplona/Espagne (3 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. SUP3; S497-S508; Bibl. 114 ref. |
LA : | Anglais |
EA : | The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Dopamine; Lévodopa; Traitement |
FG : | Catécholamine; Neurotransmetteur; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Dopamine; Levodopa; Treatment |
EG : | Catecholamine; Neurotransmitter; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Dopamina; Levodopa; Tratamiento |
LO : | INIST-20953.354000185584120010 |
ID : | 08-0466142 |
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Pascal:08-0466142Le document en format XML
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<front><div type="abstract" xml:lang="en">The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases.</div>
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<ET>The History of Dopamine and Levodopa in the Treatment of Parkinson's Disease</ET>
<AU>FAHN (Stanley); OLANOW (C. Warren); LEES (Andrew); OBESO (Jose)</AU>
<AF>Columbia University/New York/Etats-Unis (1 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, New York/Etats-Unis (1 aut.); Department of Neurology, Reta Lila Institute of Neurological Studies/London/Royaume-Uni (2 aut.); Department of Neurology, University of Navarra/Pamplona/Espagne (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. SUP3; S497-S508; Bibl. 114 ref.</SO>
<LA>Anglais</LA>
<EA>The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases.</EA>
<CC>002B17; 002B17G</CC>
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<ED>Parkinson disease; Nervous system diseases; Dopamine; Levodopa; Treatment</ED>
<EG>Catecholamine; Neurotransmitter; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Dopamina; Levodopa; Tratamiento</SD>
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