The Prodromal Phase of Sporadic Parkinson's Disease : Does It Exist and If So How Long Is It?
Identifieur interne : 001098 ( PascalFrancis/Corpus ); précédent : 001097; suivant : 001099The Prodromal Phase of Sporadic Parkinson's Disease : Does It Exist and If So How Long Is It?
Auteurs : Christopher H. HawkesSource :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
It is frequently assumed that idiopathic Parkinson's disease starts with several nonmotor symptoms and signs, but the evidence for this stage in the disease process is of variable quality. This review evaluates the more robust prospective or pathologically confirmed publications to establish whether there is a premotor period and if so what is its duration. The most informative studies are considered to be those concerned with olfaction, dysautonomia, and sleep disorder. Estimates for the duration of the prodromal phase vary from months to decades. It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established.
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Format Inist (serveur)
NO : | PASCAL 08-0522174 INIST |
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ET : | The Prodromal Phase of Sporadic Parkinson's Disease : Does It Exist and If So How Long Is It? |
AU : | HAWKES (Christopher H.) |
AF : | Neuroscience Centre, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry/London/Royaume-Uni (1 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 13; Pp. 1799-1807; Bibl. 87 ref. |
LA : | Anglais |
EA : | It is frequently assumed that idiopathic Parkinson's disease starts with several nonmotor symptoms and signs, but the evidence for this stage in the disease process is of variable quality. This review evaluates the more robust prospective or pathologically confirmed publications to establish whether there is a premotor period and if so what is its duration. The most informative studies are considered to be those concerned with olfaction, dysautonomia, and sleep disorder. Estimates for the duration of the prodromal phase vary from months to decades. It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Sporadique |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Sporadic |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Esporádico |
LO : | INIST-20953.354000184468160010 |
ID : | 08-0522174 |
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Pascal:08-0522174Le document en format XML
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<front><div type="abstract" xml:lang="en">It is frequently assumed that idiopathic Parkinson's disease starts with several nonmotor symptoms and signs, but the evidence for this stage in the disease process is of variable quality. This review evaluates the more robust prospective or pathologically confirmed publications to establish whether there is a premotor period and if so what is its duration. The most informative studies are considered to be those concerned with olfaction, dysautonomia, and sleep disorder. Estimates for the duration of the prodromal phase vary from months to decades. It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established.</div>
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<ET>The Prodromal Phase of Sporadic Parkinson's Disease : Does It Exist and If So How Long Is It?</ET>
<AU>HAWKES (Christopher H.)</AU>
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<DT>Publication en série; Niveau analytique</DT>
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