MovDisordV3, PascalFrancis, Corpus, bibRecord, 001020

Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation

Identifieur interne : 001020 ( PascalFrancis/Corpus ); précédent : 001019; suivant : 001021

Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation

Auteurs : Elina Tripoliti ; Ludvic Zrinzo ; Irene Martinez-Torres ; Stephen Tisch ; Eleanor Frost ; Ellie Borrell ; Marwan I. Hariz ; Patricia Limousin

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:09-0058924

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Tension électrique, Amplitude, Parole, Noyau sousthalamique, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Amplitude, Deep brain stimulation, Nervous system diseases, Speech, Subthalamic nucleus, Voltage.

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 23`
A06				`@2 16`
A08	`01`	`1`	`ENG`	`@1 Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation`
A11	`01`	`1`		`@1 TRIPOLITI (Elina)`
A11	`02`	`1`		`@1 ZRINZO (Ludvic)`
A11	`03`	`1`		`@1 MARTINEZ-TORRES (Irene)`
A11	`04`	`1`		`@1 TISCH (Stephen)`
A11	`05`	`1`		`@1 FROST (Eleanor)`
A11	`06`	`1`		`@1 BORRELL (Ellie)`
A11	`07`	`1`		`@1 HARIZ (Marwan I.)`
A11	`08`	`1`		`@1 LIMOUSIN (Patricia)`
A14	`01`			`@1 Unit of Functional Neurosurgery, Sohell Department, Institute of Neurology @2 London @3 GBR @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A20				`@1 2377-2383`
A21				`@1 2008`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000196116650130`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 37 ref.`
A47	`01`	`1`		`@0 09-0058924`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B26I`
C03	`01`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Tension électrique @5 09`
C03	`02`	`X`	`ENG`	`@0 Voltage @5 09`
C03	`02`	`X`	`SPA`	`@0 Voltaje @5 09`
C03	`03`	`X`	`FRE`	`@0 Amplitude @5 10`
C03	`03`	`X`	`ENG`	`@0 Amplitude @5 10`
C03	`03`	`X`	`SPA`	`@0 Amplitud @5 10`
C03	`04`	`X`	`FRE`	`@0 Parole @5 11`
C03	`04`	`X`	`ENG`	`@0 Speech @5 11`
C03	`04`	`X`	`SPA`	`@0 Habla @5 11`
C03	`05`	`X`	`FRE`	`@0 Noyau sousthalamique @5 12`
C03	`05`	`X`	`ENG`	`@0 Subthalamic nucleus @5 12`
C03	`05`	`X`	`SPA`	`@0 Núcleo subtalámico @5 12`
C03	`06`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`06`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
N21				`@1 040`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0058924 INIST
ET :	Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation
AU :	TRIPOLITI (Elina); ZRINZO (Ludvic); MARTINEZ-TORRES (Irene); TISCH (Stephen); FROST (Eleanor); BORRELL (Ellie); HARIZ (Marwan I.); LIMOUSIN (Patricia)
AF :	Unit of Functional Neurosurgery, Sohell Department, Institute of Neurology/London/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 16; Pp. 2377-2383; Bibl. 37 ref.
LA :	Anglais
EA :	Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.
CC :	002B17; 002B26I
FD :	Pathologie du système nerveux; Tension électrique; Amplitude; Parole; Noyau sousthalamique; Stimulation cérébrale profonde
FG :	Encéphale; Système nerveux central
ED :	Nervous system diseases; Voltage; Amplitude; Speech; Subthalamic nucleus; Deep brain stimulation
EG :	Encephalon; Central nervous system
SD :	Sistema nervioso patología; Voltaje; Amplitud; Habla; Núcleo subtalámico
LO :	INIST-20953.354000196116650130
ID :	09-0058924

Links to Exploration step

Pascal:09-0058924

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amplitude</term>
<term>Deep brain stimulation</term>
<term>Nervous system diseases</term>
<term>Speech</term>
<term>Subthalamic nucleus</term>
<term>Voltage</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du   système nerveux</term>
<term>Tension électrique</term>
<term>Amplitude</term>
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<front><div type="abstract" xml:lang="en">Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.</div>
</front>
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<fA11 i1="01" i2="1"><s1>TRIPOLITI (Elina)</s1>
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<fA11 i1="02" i2="1"><s1>ZRINZO (Ludvic)</s1>
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<fA20><s1>2377-2383</s1>
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<fA21><s1>2008</s1>
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<fA23 i1="01"><s0>ENG</s0>
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<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>37 ref.</s0>
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<fA60><s1>P</s1>
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<fC01 i1="01" l="ENG"><s0>Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.</s0>
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<s5>11</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Speech</s0>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Habla</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Subthalamic nucleus</s0>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Núcleo subtalámico</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
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<server><NO>PASCAL 09-0058924 INIST</NO>
<ET>Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation</ET>
<AU>TRIPOLITI (Elina); ZRINZO (Ludvic); MARTINEZ-TORRES (Irene); TISCH (Stephen); FROST (Eleanor); BORRELL (Ellie); HARIZ (Marwan I.); LIMOUSIN (Patricia)</AU>
<AF>Unit of Functional Neurosurgery, Sohell Department, Institute of Neurology/London/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 16; Pp. 2377-2383; Bibl. 37 ref.</SO>
<LA>Anglais</LA>
<EA>Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.</EA>
<CC>002B17; 002B26I</CC>
<FD>Pathologie du   système nerveux; Tension électrique; Amplitude; Parole; Noyau sousthalamique; Stimulation cérébrale profonde</FD>
<FG>Encéphale; Système nerveux central</FG>
<ED>Nervous system diseases; Voltage; Amplitude; Speech; Subthalamic nucleus; Deep brain stimulation</ED>
<EG>Encephalon; Central nervous system</EG>
<SD>Sistema nervioso patología; Voltaje; Amplitud; Habla; Núcleo subtalámico</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation

Effects of Contact Location and Voltage Amplitude on Speech and Movement in Bilateral Subthalamic Nucleus Deep Brain Stimulation

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