Movement Disorders (revue)

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Optimizing Algorithms to Identify Parkinson's Disease Cases Within an Administrative Database

Identifieur interne : 001007 ( PascalFrancis/Corpus ); précédent : 001006; suivant : 001008

Optimizing Algorithms to Identify Parkinson's Disease Cases Within an Administrative Database

Auteurs : Nicholas R. Szumski ; Eric M. Cheng

Source :

RBID : Pascal:09-0094106

Descripteurs français

English descriptors

Abstract

Patients assigned the diagnostic ICD-9-CM code for Parkinson's disease (PD) in an administrative database may not truly carry that diagnosis because of the various error sources. Improved ability to identify PD cases within databases may facilitate specific research goals. Experienced chart reviewers abstracted the working diagnosis of all 577 patients assigned diagnostic code 332.0 (PD) during 1 year at a VA Healthcare System. We then tested the ability of various algorithms making use of PD and non-PD diagnostic codes, specialty of clinics visited, and medication prescription data to predict the abstracted working diagnosis. Chart review determined 436 (75.6%) patients to be PD or Possibly PD, and 141 (24.4%) to be Not PD. Our tiered consensus algorithm preferentially used data from specialists over non-specialists improved PPV to 83.2% (P = 0.003 vs. baseline). When presence of a PD prescription was an additional criterion, PPV increased further to 88.2% (P = 0.04 vs. without medication criterion), but sensitivity decreased from 87.4 to 77.1% (P = 0.0001). We demonstrate that algorithms provide better identification of PD cases than using a single occurrence of the diagnostic code for PD, and modifications of such algorithms can be tuned to maximize parameters that best meet the goals of a particular database query.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A05       @2 24
A06       @2 1
A08 01  1  ENG  @1 Optimizing Algorithms to Identify Parkinson's Disease Cases Within an Administrative Database
A11 01  1    @1 SZUMSKI (Nicholas R.)
A11 02  1    @1 CHENG (Eric M.)
A14 01      @1 Department of Neurology, UCLA @2 Los Angeles, California @3 USA @Z 1 aut. @Z 2 aut.
A14 02      @1 Southwest Parkinson's Disease Research, Education, and Clinical Center (PADRECC) @2 Los Angeles, California @3 USA @Z 1 aut. @Z 2 aut.
A14 03      @1 Department of Neurology, VA Greater Los Angeles Healthcare System @2 Los Angeles, California @3 USA @Z 1 aut. @Z 2 aut.
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A21       @1 2009
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000186473060060
A44       @0 0000 @1 © 2009 INIST-CNRS. All rights reserved.
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A47 01  1    @0 09-0094106
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C01 01    ENG  @0 Patients assigned the diagnostic ICD-9-CM code for Parkinson's disease (PD) in an administrative database may not truly carry that diagnosis because of the various error sources. Improved ability to identify PD cases within databases may facilitate specific research goals. Experienced chart reviewers abstracted the working diagnosis of all 577 patients assigned diagnostic code 332.0 (PD) during 1 year at a VA Healthcare System. We then tested the ability of various algorithms making use of PD and non-PD diagnostic codes, specialty of clinics visited, and medication prescription data to predict the abstracted working diagnosis. Chart review determined 436 (75.6%) patients to be PD or Possibly PD, and 141 (24.4%) to be Not PD. Our tiered consensus algorithm preferentially used data from specialists over non-specialists improved PPV to 83.2% (P = 0.003 vs. baseline). When presence of a PD prescription was an additional criterion, PPV increased further to 88.2% (P = 0.04 vs. without medication criterion), but sensitivity decreased from 87.4 to 77.1% (P = 0.0001). We demonstrate that algorithms provide better identification of PD cases than using a single occurrence of the diagnostic code for PD, and modifications of such algorithms can be tuned to maximize parameters that best meet the goals of a particular database query.
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C03 02  X  ENG  @0 Nervous system diseases @5 02
C03 02  X  SPA  @0 Sistema nervioso patología @5 02
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C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 068
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Format Inist (serveur)

NO : PASCAL 09-0094106 INIST
ET : Optimizing Algorithms to Identify Parkinson's Disease Cases Within an Administrative Database
AU : SZUMSKI (Nicholas R.); CHENG (Eric M.)
AF : Department of Neurology, UCLA/Los Angeles, California/Etats-Unis (1 aut., 2 aut.); Southwest Parkinson's Disease Research, Education, and Clinical Center (PADRECC)/Los Angeles, California/Etats-Unis (1 aut., 2 aut.); Department of Neurology, VA Greater Los Angeles Healthcare System/Los Angeles, California/Etats-Unis (1 aut., 2 aut.)
DT : Publication en série; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 1; Pp. 51-56; Bibl. 15 ref.
LA : Anglais
EA : Patients assigned the diagnostic ICD-9-CM code for Parkinson's disease (PD) in an administrative database may not truly carry that diagnosis because of the various error sources. Improved ability to identify PD cases within databases may facilitate specific research goals. Experienced chart reviewers abstracted the working diagnosis of all 577 patients assigned diagnostic code 332.0 (PD) during 1 year at a VA Healthcare System. We then tested the ability of various algorithms making use of PD and non-PD diagnostic codes, specialty of clinics visited, and medication prescription data to predict the abstracted working diagnosis. Chart review determined 436 (75.6%) patients to be PD or Possibly PD, and 141 (24.4%) to be Not PD. Our tiered consensus algorithm preferentially used data from specialists over non-specialists improved PPV to 83.2% (P = 0.003 vs. baseline). When presence of a PD prescription was an additional criterion, PPV increased further to 88.2% (P = 0.04 vs. without medication criterion), but sensitivity decreased from 87.4 to 77.1% (P = 0.0001). We demonstrate that algorithms provide better identification of PD cases than using a single occurrence of the diagnostic code for PD, and modifications of such algorithms can be tuned to maximize parameters that best meet the goals of a particular database query.
CC : 002B17; 002B17G
FD : Maladie de Parkinson; Pathologie du système nerveux; Algorithme; Base de données; Valeur prédictive; Sensibilité; Spécificité
FG : Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED : Parkinson disease; Nervous system diseases; Algorithm; Database; Predictive value; Sensitivity; Specificity
EG : Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD : Parkinson enfermedad; Sistema nervioso patología; Algoritmo; Base dato; Valor predictivo; Sensibilidad; Especificidad
LO : INIST-20953.354000186473060060
ID : 09-0094106

Links to Exploration step

Pascal:09-0094106

Le document en format XML

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<div type="abstract" xml:lang="en">Patients assigned the diagnostic ICD-9-CM code for Parkinson's disease (PD) in an administrative database may not truly carry that diagnosis because of the various error sources. Improved ability to identify PD cases within databases may facilitate specific research goals. Experienced chart reviewers abstracted the working diagnosis of all 577 patients assigned diagnostic code 332.0 (PD) during 1 year at a VA Healthcare System. We then tested the ability of various algorithms making use of PD and non-PD diagnostic codes, specialty of clinics visited, and medication prescription data to predict the abstracted working diagnosis. Chart review determined 436 (75.6%) patients to be PD or Possibly PD, and 141 (24.4%) to be Not PD. Our tiered consensus algorithm preferentially used data from specialists over non-specialists improved PPV to 83.2% (P = 0.003 vs. baseline). When presence of a PD prescription was an additional criterion, PPV increased further to 88.2% (P = 0.04 vs. without medication criterion), but sensitivity decreased from 87.4 to 77.1% (P = 0.0001). We demonstrate that algorithms provide better identification of PD cases than using a single occurrence of the diagnostic code for PD, and modifications of such algorithms can be tuned to maximize parameters that best meet the goals of a particular database query.</div>
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<NO>PASCAL 09-0094106 INIST</NO>
<ET>Optimizing Algorithms to Identify Parkinson's Disease Cases Within an Administrative Database</ET>
<AU>SZUMSKI (Nicholas R.); CHENG (Eric M.)</AU>
<AF>Department of Neurology, UCLA/Los Angeles, California/Etats-Unis (1 aut., 2 aut.); Southwest Parkinson's Disease Research, Education, and Clinical Center (PADRECC)/Los Angeles, California/Etats-Unis (1 aut., 2 aut.); Department of Neurology, VA Greater Los Angeles Healthcare System/Los Angeles, California/Etats-Unis (1 aut., 2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 1; Pp. 51-56; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Patients assigned the diagnostic ICD-9-CM code for Parkinson's disease (PD) in an administrative database may not truly carry that diagnosis because of the various error sources. Improved ability to identify PD cases within databases may facilitate specific research goals. Experienced chart reviewers abstracted the working diagnosis of all 577 patients assigned diagnostic code 332.0 (PD) during 1 year at a VA Healthcare System. We then tested the ability of various algorithms making use of PD and non-PD diagnostic codes, specialty of clinics visited, and medication prescription data to predict the abstracted working diagnosis. Chart review determined 436 (75.6%) patients to be PD or Possibly PD, and 141 (24.4%) to be Not PD. Our tiered consensus algorithm preferentially used data from specialists over non-specialists improved PPV to 83.2% (P = 0.003 vs. baseline). When presence of a PD prescription was an additional criterion, PPV increased further to 88.2% (P = 0.04 vs. without medication criterion), but sensitivity decreased from 87.4 to 77.1% (P = 0.0001). We demonstrate that algorithms provide better identification of PD cases than using a single occurrence of the diagnostic code for PD, and modifications of such algorithms can be tuned to maximize parameters that best meet the goals of a particular database query.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Algorithme; Base de données; Valeur prédictive; Sensibilité; Spécificité</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Algorithm; Database; Predictive value; Sensitivity; Specificity</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Algoritmo; Base dato; Valor predictivo; Sensibilidad; Especificidad</SD>
<LO>INIST-20953.354000186473060060</LO>
<ID>09-0094106</ID>
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