MovDisordV3, PascalFrancis, Corpus, bibRecord, 000F58

Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death

Identifieur interne : 000F58 ( PascalFrancis/Corpus ); précédent : 000F57; suivant : 000F59

Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death

Auteurs : Helen Petrovitch ; Robert D. Abbott ; G. Webster Ross ; James Nelson ; Kamal H. Masaki ; Caroline M. Tanner ; Lenore J. Launer ; Lon R. White

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0136798

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Constipation, Pathologie du système nerveux, Locus niger, Mort cellulaire, Corps Lewy, Neurone.

English descriptors

KwdEn :
- Cell death, Constipation, Lewy body, Locus niger, Nervous system diseases, Neuron, Parkinson disease.

Abstract

Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm²) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 09-0136798 INIST
ET :	Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death
AU :	PETROVITCH (Helen); ABBOTT (Robert D.); WEBSTER ROSS (G.); NELSON (James); MASAKI (Kamal H.); TANNER (Caroline M.); LAUNER (Lenore J.); WHITE (Lon R.)
AF :	Pacific Health Research Institute/Honolulu, Hawaii/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut.); The Honolulu-Asia Aging Study, Kuakini Medical Center/Honolulu, Hawaii/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut.); Department of Medicine, University of Hawaii John A. Burns School of Medicine/Honolulu, Hawaii/Etats-Unis (1 aut., 3 aut.); Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine/Honolulu, Hawaii/Etats-Unis (1 aut., 3 aut., 5 aut., 8 aut.); Division of Biostatistics and Epidemiology, University of Virginia School of Medicine/Charlottesville, Virginia/Etats-Unis (2 aut.); Department of Health Science, Shiga University of Medical Science/Otsu/Japon (2 aut.); Veterans Affairs Pacific Islands Health Care System/Honolulu, Hawaii/Etats-Unis (3 aut.); Department of Pathology, University of Hawaii John A. Burns School of Medicine/Honolulu, Hawaii/Etats-Unis (4 aut.); Parkinson's Institute/Sunnyvale, California/Etats-Unis (6 aut.); National Institute on Aging, National Institutes of Health/Bethesda, Maryland/Etats-Unis (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 3; Pp. 371-376; Bibl. 38 ref.
LA :	Anglais
EA :	Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm²) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Constipation; Pathologie du système nerveux; Locus niger; Mort cellulaire; Corps Lewy; Neurone
FG :	Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie de l'appareil digestif; Pathologie de l'intestin
ED :	Parkinson disease; Constipation; Nervous system diseases; Locus niger; Cell death; Lewy body; Neuron
EG :	Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Digestive diseases; Intestinal disease
SD :	Parkinson enfermedad; Constipación; Sistema nervioso patología; Locus níger; Muerte celular; Cuerpo Lewy; Neurona
LO :	INIST-20953.354000186999840080
ID :	09-0136798

Links to Exploration step

Pascal:09-0136798

Le document en format XML

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<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death</title>
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<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell death</term>
<term>Constipation</term>
<term>Lewy body</term>
<term>Locus niger</term>
<term>Nervous system diseases</term>
<term>Neuron</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Constipation</term>
<term>Pathologie du   système nerveux</term>
<term>Locus niger</term>
<term>Mort cellulaire</term>
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<term>Neurone</term>
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<front><div type="abstract" xml:lang="en">Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm<sup>2</sup>
) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.</div>
</front>
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<fA11 i1="05" i2="1"><s1>MASAKI (Kamal H.)</s1>
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<fA11 i1="06" i2="1"><s1>TANNER (Caroline M.)</s1>
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<fA11 i1="07" i2="1"><s1>LAUNER (Lenore J.)</s1>
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<fA11 i1="08" i2="1"><s1>WHITE (Lon R.)</s1>
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<fA14 i1="01"><s1>Pacific Health Research Institute</s1>
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<fA14 i1="05"><s1>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine</s1>
<s2>Charlottesville, Virginia</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Health Science, Shiga University of Medical Science</s1>
<s2>Otsu</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Veterans Affairs Pacific Islands Health Care System</s1>
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<s3>USA</s3>
<sZ>3 aut.</sZ>
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<fA14 i1="08"><s1>Department of Pathology, University of Hawaii John A. Burns School of Medicine</s1>
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<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
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<sZ>6 aut.</sZ>
</fA14>
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<fC01 i1="01" l="ENG"><s0>Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm<sup>2</sup>
) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.</s0>
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<fC02 i1="02" i2="X"><s0>002B17G</s0>
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<s5>01</s5>
</fC03>
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<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Constipation</s0>
<s5>02</s5>
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<s5>02</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Constipación</s0>
<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>03</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
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<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Locus niger</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Locus niger</s0>
<s5>09</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Locus níger</s0>
<s5>09</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Mort cellulaire</s0>
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</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Corps Lewy</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Lewy body</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Cuerpo Lewy</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Neurone</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Neuron</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Neurona</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Pathologie de l'appareil digestif</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Digestive diseases</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Aparato digestivo patología</s0>
<s5>44</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Pathologie de l'intestin</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Intestinal disease</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Intestino patología</s0>
<s5>45</s5>
</fC07>
<fN21><s1>096</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 09-0136798 INIST</NO>
<ET>Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death</ET>
<AU>PETROVITCH (Helen); ABBOTT (Robert D.); WEBSTER ROSS (G.); NELSON (James); MASAKI (Kamal H.); TANNER (Caroline M.); LAUNER (Lenore J.); WHITE (Lon R.)</AU>
<AF>Pacific Health Research Institute/Honolulu, Hawaii/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut.); The Honolulu-Asia Aging Study, Kuakini Medical Center/Honolulu, Hawaii/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut.); Department of Medicine, University of Hawaii John A. Burns School of Medicine/Honolulu, Hawaii/Etats-Unis (1 aut., 3 aut.); Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine/Honolulu, Hawaii/Etats-Unis (1 aut., 3 aut., 5 aut., 8 aut.); Division of Biostatistics and Epidemiology, University of Virginia School of Medicine/Charlottesville, Virginia/Etats-Unis (2 aut.); Department of Health Science, Shiga University of Medical Science/Otsu/Japon (2 aut.); Veterans Affairs Pacific Islands Health Care System/Honolulu, Hawaii/Etats-Unis (3 aut.); Department of Pathology, University of Hawaii John A. Burns School of Medicine/Honolulu, Hawaii/Etats-Unis (4 aut.); Parkinson's Institute/Sunnyvale, California/Etats-Unis (6 aut.); National Institute on Aging, National Institutes of Health/Bethesda, Maryland/Etats-Unis (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 3; Pp. 371-376; Bibl. 38 ref.</SO>
<LA>Anglais</LA>
<EA>Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm<sup>2</sup>
) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Constipation; Pathologie du   système nerveux; Locus niger; Mort cellulaire; Corps Lewy; Neurone</FD>
<FG>Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Pathologie de l'appareil digestif; Pathologie de l'intestin</FG>
<ED>Parkinson disease; Constipation; Nervous system diseases; Locus niger; Cell death; Lewy body; Neuron</ED>
<EG>Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Digestive diseases; Intestinal disease</EG>
<SD>Parkinson enfermedad; Constipación; Sistema nervioso patología; Locus níger; Muerte celular; Cuerpo Lewy; Neurona</SD>
<LO>INIST-20953.354000186999840080</LO>
<ID>09-0136798</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death

Bowel Movement Frequency in Late-Life and Substantia Nigra Neuron Density at Death

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