MovDisordV3, PascalFrancis, Corpus, bibRecord, 000E24

The Course of Depressive Symptoms in Early Parkinson's Disease

Identifieur interne : 000E24 ( PascalFrancis/Corpus ); précédent : 000E23; suivant : 000E25

The Course of Depressive Symptoms in Early Parkinson's Disease

Auteurs : Bernard Ravina ; Jordan Elm ; Richard Camicioli ; Peter G. Como ; Laura Marsh ; Joseph Jankovic ; Daniel Weintraub

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0349965

Descripteurs français

Pascal (Inist)
- Etat dépressif, Maladie de Parkinson, Pathologie du système nerveux, Pronostic.

English descriptors

KwdEn :
- Depression, Nervous system diseases, Parkinson disease, Prognosis.

Abstract

Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 CAMICIOLI (Richard)`
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A11	`05`	`1`		`@1 MARSH (Laura)`
A11	`06`	`1`		`@1 JANKOVIC (Joseph)`
A11	`07`	`1`		`@1 WEINTRAUB (Daniel)`
A14	`01`			`@1 Department of Neurology, University of Rochester School of Medicine and Dentistry @2 Rochester, New York @3 USA @Z 1 aut. @Z 4 aut.`
A14	`02`			`@1 Department of Biostatistics, Medical University of South Carolina @2 Charleston, South Carolina @3 USA @Z 2 aut.`
A14	`03`			`@1 Department of Neurology, University of Alberta @2 Edmonton @3 CAN @Z 3 aut.`
A14	`04`			`@1 Department of Psychiatry, Johns Hopkins University @2 Baltimore, Maryland @3 USA @Z 5 aut.`
A14	`05`			`@1 Department of Neurology, Johns Hopkins University @2 Baltimore, Maryland @3 USA @Z 5 aut.`
A14	`06`			`@1 Department of Neurology, Baylor College of Medicine @2 Houston, Texas @3 USA @Z 6 aut.`
A14	`07`			`@1 Department of Psychiatry, University of Pennsylvania @2 Philadelphia, Pennsylvania @3 USA @Z 7 aut.`
A14	`08`			`@1 Department of Neurology, University of Pennsylvania @2 Philadelphia, Pennsylvania @3 USA @Z 7 aut.`
A20				`@1 1306-1311`
A21				`@1 2009`
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C01	`01`		`ENG`	@0 Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
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C03	`01`	`X`	`ENG`	`@0 Depression @5 01`
C03	`01`	`X`	`SPA`	`@0 Estado depresivo @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
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C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
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C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Pronostic @5 09`
C03	`04`	`X`	`ENG`	`@0 Prognosis @5 09`
C03	`04`	`X`	`SPA`	`@0 Pronóstico @5 09`
C07	`01`	`X`	`FRE`	`@0 Trouble de l'humeur @5 37`
C07	`01`	`X`	`ENG`	`@0 Mood disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Trastorno humor @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
C07	`04`	`X`	`ENG`	`@0 Degenerative disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
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Format Inist (serveur)

NO :	PASCAL 09-0349965 INIST
ET :	The Course of Depressive Symptoms in Early Parkinson's Disease
AU :	RAVINA (Bernard); ELM (Jordan); CAMICIOLI (Richard); COMO (Peter G.); MARSH (Laura); JANKOVIC (Joseph); WEINTRAUB (Daniel)
AF :	Department of Neurology, University of Rochester School of Medicine and Dentistry/Rochester, New York/Etats-Unis (1 aut., 4 aut.); Department of Biostatistics, Medical University of South Carolina/Charleston, South Carolina/Etats-Unis (2 aut.); Department of Neurology, University of Alberta/Edmonton/Canada (3 aut.); Department of Psychiatry, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (6 aut.); Department of Psychiatry, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.); Department of Neurology, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1306-1311; Bibl. 28 ref.
LA :	Anglais
EA :	Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.
CC :	002B17; 002B17G
FD :	Etat dépressif; Maladie de Parkinson; Pathologie du système nerveux; Pronostic
FG :	Trouble de l'humeur; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Depression; Parkinson disease; Nervous system diseases; Prognosis
EG :	Mood disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Estado depresivo; Parkinson enfermedad; Sistema nervioso patología; Pronóstico
LO :	INIST-20953.354000170902500070
ID :	09-0349965

Links to Exploration step

Pascal:09-0349965

Le document en format XML

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<author><name sortKey="Elm, Jordan" sort="Elm, Jordan" uniqKey="Elm J" first="Jordan" last="Elm">Jordan Elm</name>
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<author><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name>
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<front><div type="abstract" xml:lang="en">Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.</div>
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<fA14 i1="03"><s1>Department of Neurology, University of Alberta</s1>
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<fA14 i1="04"><s1>Department of Psychiatry, Johns Hopkins University</s1>
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<fA14 i1="06"><s1>Department of Neurology, Baylor College of Medicine</s1>
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<fA14 i1="07"><s1>Department of Psychiatry, University of Pennsylvania</s1>
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<fC01 i1="01" l="ENG"><s0>Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.</s0>
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<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
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<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Depression</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Estado depresivo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
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<s5>03</s5>
</fC03>
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<s5>03</s5>
</fC03>
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<s5>03</s5>
</fC03>
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<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>09</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Trouble de l'humeur</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Mood disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Trastorno humor</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>257</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 09-0349965 INIST</NO>
<ET>The Course of Depressive Symptoms in Early Parkinson's Disease</ET>
<AU>RAVINA (Bernard); ELM (Jordan); CAMICIOLI (Richard); COMO (Peter G.); MARSH (Laura); JANKOVIC (Joseph); WEINTRAUB (Daniel)</AU>
<AF>Department of Neurology, University of Rochester School of Medicine and Dentistry/Rochester, New York/Etats-Unis (1 aut., 4 aut.); Department of Biostatistics, Medical University of South Carolina/Charleston, South Carolina/Etats-Unis (2 aut.); Department of Neurology, University of Alberta/Edmonton/Canada (3 aut.); Department of Psychiatry, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (6 aut.); Department of Psychiatry, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.); Department of Neurology, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1306-1311; Bibl. 28 ref.</SO>
<LA>Anglais</LA>
<EA>Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.</EA>
<CC>002B17; 002B17G</CC>
<FD>Etat dépressif; Maladie de Parkinson; Pathologie du système nerveux; Pronostic</FD>
<FG>Trouble de l'humeur; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Depression; Parkinson disease; Nervous system diseases; Prognosis</ED>
<EG>Mood disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Estado depresivo; Parkinson enfermedad; Sistema nervioso patología; Pronóstico</SD>
<LO>INIST-20953.354000170902500070</LO>
<ID>09-0349965</ID>
</server>
</inist>
</record>

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Movement Disorders (revue)

The Course of Depressive Symptoms in Early Parkinson's Disease

The Course of Depressive Symptoms in Early Parkinson's Disease

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