MovDisordV3, PascalFrancis, Corpus, bibRecord, 000E17

Reproductive Factors, Exogenous Estrogen Use, and Risk of Parkinson's Disease

Identifieur interne : 000E17 ( PascalFrancis/Corpus ); précédent : 000E16; suivant : 000E18

Reproductive Factors, Exogenous Estrogen Use, and Risk of Parkinson's Disease

Auteurs : Kelly Claire Simon ; HONGLEI CHEN ; XIANG GAO ; Michael A. Schwarzschild ; Alberto Ascherio

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0349990

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Oestrogène, Facteur risque, Epidémiologie.

English descriptors

KwdEn :
- Epidemiology, Estrogen, Nervous system diseases, Parkinson disease, Risk factor.

Abstract

To determine if reproductive factors or exogenous estrogen are associated with risk of Parkinson's disease (PD), we conducted a prospective study with 22 years of follow-up among postmenopausal participants in the Nurses' Health Study. Relative risks (RRs) and 95% confidence intervals (CIs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. Risk of PD was not significantly associated with any of the reproductive factors measured or exogenous estrogen use. Use of postmenopausal hormones, however, may modify the associations of smoking and caffeine intake with PD risk. The inverse relation between smoking and PD risk was attenuated among ever users of postmenopausal hormones (P for interaction = 0.05). Similar results were obtained for caffeine (P for interaction = 0.09). In exploratory analyses, women using progestin-only hormones were found to have an increased PD risk, but this result was based on a very small number of cases (n = 4). In this large longitudinal study, we found no evidence of a beneficial effect of exogenous or endogenous estrogens on risk of PD. The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 SIMON (Kelly Claire)`
A11	`02`	`1`		`@1 HONGLEI CHEN`
A11	`03`	`1`		`@1 XIANG GAO`
A11	`04`	`1`		`@1 SCHWARZSCHILD (Michael A.)`
A11	`05`	`1`		`@1 ASCHERIO (Alberto)`
A14	`01`			`@1 Department of Nutrition, Harvard School of Public Health @2 Boston, Massachusetts @3 USA @Z 1 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 Epidemiology Branch, National Institute of Environmental Health Sciences @2 Research Triangle Park, North Carolina @3 USA @Z 2 aut.`
A14	`03`			`@1 Department of Neurology, Massachusetts General Hospital @2 Boston, Massachusetts @3 USA @Z 4 aut.`
A14	`04`			`@1 Department of Epidemiology, Harvard School of Public Health @2 Boston, Massachusetts @3 USA @Z 5 aut.`
A14	`05`			`@1 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School @2 Boston, Massachusetts @3 USA @Z 5 aut.`
A20				`@1 1359-1365`
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A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 To determine if reproductive factors or exogenous estrogen are associated with risk of Parkinson's disease (PD), we conducted a prospective study with 22 years of follow-up among postmenopausal participants in the Nurses' Health Study. Relative risks (RRs) and 95% confidence intervals (CIs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. Risk of PD was not significantly associated with any of the reproductive factors measured or exogenous estrogen use. Use of postmenopausal hormones, however, may modify the associations of smoking and caffeine intake with PD risk. The inverse relation between smoking and PD risk was attenuated among ever users of postmenopausal hormones (P for interaction = 0.05). Similar results were obtained for caffeine (P for interaction = 0.09). In exploratory analyses, women using progestin-only hormones were found to have an increased PD risk, but this result was based on a very small number of cases (n = 4). In this large longitudinal study, we found no evidence of a beneficial effect of exogenous or endogenous estrogens on risk of PD. The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations.
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C03	`03`	`X`	`FRE`	`@0 Oestrogène @5 09`
C03	`03`	`X`	`ENG`	`@0 Estrogen @5 09`
C03	`03`	`X`	`SPA`	`@0 Estrógeno @5 09`
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C03	`05`	`X`	`ENG`	`@0 Epidemiology @5 11`
C03	`05`	`X`	`SPA`	`@0 Epidemiología @5 11`
C07	`01`	`X`	`FRE`	`@0 Hormone ovarienne @5 37`
C07	`01`	`X`	`ENG`	`@0 Ovarian hormone @5 37`
C07	`01`	`X`	`SPA`	`@0 Hormona ovárica @5 37`
C07	`02`	`X`	`FRE`	`@0 Hormone stéroïde sexuelle @5 38`
C07	`02`	`X`	`ENG`	`@0 Sex steroid hormone @5 38`
C07	`02`	`X`	`SPA`	`@0 Hormona esteroide sexual @5 38`
C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 42`
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Format Inist (serveur)

NO :	PASCAL 09-0349990 INIST
ET :	Reproductive Factors, Exogenous Estrogen Use, and Risk of Parkinson's Disease
AU :	SIMON (Kelly Claire); HONGLEI CHEN; XIANG GAO; SCHWARZSCHILD (Michael A.); ASCHERIO (Alberto)
AF :	Department of Nutrition, Harvard School of Public Health/Boston, Massachusetts/Etats-Unis (1 aut., 3 aut., 5 aut.); Epidemiology Branch, National Institute of Environmental Health Sciences/Research Triangle Park, North Carolina/Etats-Unis (2 aut.); Department of Neurology, Massachusetts General Hospital/Boston, Massachusetts/Etats-Unis (4 aut.); Department of Epidemiology, Harvard School of Public Health/Boston, Massachusetts/Etats-Unis (5 aut.); Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School/Boston, Massachusetts/Etats-Unis (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1359-1365; Bibl. 43 ref.
LA :	Anglais
EA :	To determine if reproductive factors or exogenous estrogen are associated with risk of Parkinson's disease (PD), we conducted a prospective study with 22 years of follow-up among postmenopausal participants in the Nurses' Health Study. Relative risks (RRs) and 95% confidence intervals (CIs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. Risk of PD was not significantly associated with any of the reproductive factors measured or exogenous estrogen use. Use of postmenopausal hormones, however, may modify the associations of smoking and caffeine intake with PD risk. The inverse relation between smoking and PD risk was attenuated among ever users of postmenopausal hormones (P for interaction = 0.05). Similar results were obtained for caffeine (P for interaction = 0.09). In exploratory analyses, women using progestin-only hormones were found to have an increased PD risk, but this result was based on a very small number of cases (n = 4). In this large longitudinal study, we found no evidence of a beneficial effect of exogenous or endogenous estrogens on risk of PD. The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Oestrogène; Facteur risque; Epidémiologie
FG :	Hormone ovarienne; Hormone stéroïde sexuelle; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Estrogen; Risk factor; Epidemiology
EG :	Ovarian hormone; Sex steroid hormone; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Estrógeno; Factor riesgo; Epidemiología
LO :	INIST-20953.354000170902500150
ID :	09-0349990

Links to Exploration step

Pascal:09-0349990

Le document en format XML

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<front><div type="abstract" xml:lang="en">To determine if reproductive factors or exogenous estrogen are associated with risk of Parkinson's disease (PD), we conducted a prospective study with 22 years of follow-up among postmenopausal participants in the Nurses' Health Study. Relative risks (RRs) and 95% confidence intervals (CIs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. Risk of PD was not significantly associated with any of the reproductive factors measured or exogenous estrogen use. Use of postmenopausal hormones, however, may modify the associations of smoking and caffeine intake with PD risk. The inverse relation between smoking and PD risk was attenuated among ever users of postmenopausal hormones (P for interaction = 0.05). Similar results were obtained for caffeine (P for interaction = 0.09). In exploratory analyses, women using progestin-only hormones were found to have an increased PD risk, but this result was based on a very small number of cases (n = 4). In this large longitudinal study, we found no evidence of a beneficial effect of exogenous or endogenous estrogens on risk of PD. The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations.</div>
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<fC01 i1="01" l="ENG"><s0>To determine if reproductive factors or exogenous estrogen are associated with risk of Parkinson's disease (PD), we conducted a prospective study with 22 years of follow-up among postmenopausal participants in the Nurses' Health Study. Relative risks (RRs) and 95% confidence intervals (CIs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. Risk of PD was not significantly associated with any of the reproductive factors measured or exogenous estrogen use. Use of postmenopausal hormones, however, may modify the associations of smoking and caffeine intake with PD risk. The inverse relation between smoking and PD risk was attenuated among ever users of postmenopausal hormones (P for interaction = 0.05). Similar results were obtained for caffeine (P for interaction = 0.09). In exploratory analyses, women using progestin-only hormones were found to have an increased PD risk, but this result was based on a very small number of cases (n = 4). In this large longitudinal study, we found no evidence of a beneficial effect of exogenous or endogenous estrogens on risk of PD. The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations.</s0>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Sex steroid hormone</s0>
<s5>38</s5>
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<fC07 i1="02" i2="X" l="SPA"><s0>Hormona esteroide sexual</s0>
<s5>38</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>39</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
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<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
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<s5>40</s5>
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<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
</fC07>
<fN21><s1>257</s1>
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<fN44 i1="01"><s1>OTO</s1>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 09-0349990 INIST</NO>
<ET>Reproductive Factors, Exogenous Estrogen Use, and Risk of Parkinson's Disease</ET>
<AU>SIMON (Kelly Claire); HONGLEI CHEN; XIANG GAO; SCHWARZSCHILD (Michael A.); ASCHERIO (Alberto)</AU>
<AF>Department of Nutrition, Harvard School of Public Health/Boston, Massachusetts/Etats-Unis (1 aut., 3 aut., 5 aut.); Epidemiology Branch, National Institute of Environmental Health Sciences/Research Triangle Park, North Carolina/Etats-Unis (2 aut.); Department of Neurology, Massachusetts General Hospital/Boston, Massachusetts/Etats-Unis (4 aut.); Department of Epidemiology, Harvard School of Public Health/Boston, Massachusetts/Etats-Unis (5 aut.); Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School/Boston, Massachusetts/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1359-1365; Bibl. 43 ref.</SO>
<LA>Anglais</LA>
<EA>To determine if reproductive factors or exogenous estrogen are associated with risk of Parkinson's disease (PD), we conducted a prospective study with 22 years of follow-up among postmenopausal participants in the Nurses' Health Study. Relative risks (RRs) and 95% confidence intervals (CIs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. Risk of PD was not significantly associated with any of the reproductive factors measured or exogenous estrogen use. Use of postmenopausal hormones, however, may modify the associations of smoking and caffeine intake with PD risk. The inverse relation between smoking and PD risk was attenuated among ever users of postmenopausal hormones (P for interaction = 0.05). Similar results were obtained for caffeine (P for interaction = 0.09). In exploratory analyses, women using progestin-only hormones were found to have an increased PD risk, but this result was based on a very small number of cases (n = 4). In this large longitudinal study, we found no evidence of a beneficial effect of exogenous or endogenous estrogens on risk of PD. The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Oestrogène; Facteur risque; Epidémiologie</FD>
<FG>Hormone ovarienne; Hormone stéroïde sexuelle; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Estrogen; Risk factor; Epidemiology</ED>
<EG>Ovarian hormone; Sex steroid hormone; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Estrógeno; Factor riesgo; Epidemiología</SD>
<LO>INIST-20953.354000170902500150</LO>
<ID>09-0349990</ID>
</server>
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Movement Disorders (revue)

Reproductive Factors, Exogenous Estrogen Use, and Risk of Parkinson's Disease

Reproductive Factors, Exogenous Estrogen Use, and Risk of Parkinson's Disease

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