Imaging Amyloid in Parkinson's Disease Dementia and Dementia with Lewy Bodies with Positron Emission Tomography
Identifieur interne : 000C76 ( PascalFrancis/Corpus ); précédent : 000C75; suivant : 000C77Imaging Amyloid in Parkinson's Disease Dementia and Dementia with Lewy Bodies with Positron Emission Tomography
Auteurs : David J. BrooksSource :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Although Parkinson's disease with later dementia (PDD) and dementia with Lewy bodies (DLB) are pathologically characterized by the presence of intraneuronal Lewy inclusion bodies, amyloid deposition is also associated to varying degrees with both these disorders. Fibrillar amyloid load can now be quantitated in vivo with positron emission tomography (PET) using imaging biomarkers. Here the reported findings of 11C-PIB PET studies concerning the amyloid load associated with PD and its influence on dementia are reviewed. It is concluded that the presence of amyloid acts to accelerate the dementia process in Lewy body disorders, though has little influence on its nature. Anti-amyloid strategies could be a relevant approach for slowing dementia in a number of DLB and PDD cases.
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NO : | PASCAL 10-0038132 INIST |
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ET : | Imaging Amyloid in Parkinson's Disease Dementia and Dementia with Lewy Bodies with Positron Emission Tomography |
AU : | BROOKS (David J.); POEWE (Werner); SCHERFLER (Christopher) |
AF : | MRC Clinical Sciences Centre and Division of Neuroscience, Imperial College/London/Royaume-Uni (1 aut.); Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (1 aut., 2 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 14 SUP; S742-S747; Bibl. 38 ref. |
LA : | Anglais |
EA : | Although Parkinson's disease with later dementia (PDD) and dementia with Lewy bodies (DLB) are pathologically characterized by the presence of intraneuronal Lewy inclusion bodies, amyloid deposition is also associated to varying degrees with both these disorders. Fibrillar amyloid load can now be quantitated in vivo with positron emission tomography (PET) using imaging biomarkers. Here the reported findings of 11C-PIB PET studies concerning the amyloid load associated with PD and its influence on dementia are reviewed. It is concluded that the presence of amyloid acts to accelerate the dementia process in Lewy body disorders, though has little influence on its nature. Anti-amyloid strategies could be a relevant approach for slowing dementia in a number of DLB and PDD cases. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Démence à corps de Lewy; Pathologie du système nerveux; Amyloïde; Tomoscintigraphie; Tomographie par émission de positons; Corps Lewy |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Lewy body dementia; Nervous system diseases; Amyloid; Emission tomography; Positron emission tomography; Lewy body |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Demencia cuerpos Lewy; Sistema nervioso patología; Amiloide; Tomocentelleografía; Tomografía emisión positrones; Cuerpo Lewy |
LO : | INIST-20953.354000171427130130 |
ID : | 10-0038132 |
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Pascal:10-0038132Le document en format XML
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<front><div type="abstract" xml:lang="en">Although Parkinson's disease with later dementia (PDD) and dementia with Lewy bodies (DLB) are pathologically characterized by the presence of intraneuronal Lewy inclusion bodies, amyloid deposition is also associated to varying degrees with both these disorders. Fibrillar amyloid load can now be quantitated in vivo with positron emission tomography (PET) using imaging biomarkers. Here the reported findings of <sup>11</sup>
C-PIB PET studies concerning the amyloid load associated with PD and its influence on dementia are reviewed. It is concluded that the presence of amyloid acts to accelerate the dementia process in Lewy body disorders, though has little influence on its nature. Anti-amyloid strategies could be a relevant approach for slowing dementia in a number of DLB and PDD cases.</div>
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<ET>Imaging Amyloid in Parkinson's Disease Dementia and Dementia with Lewy Bodies with Positron Emission Tomography</ET>
<AU>BROOKS (David J.); POEWE (Werner); SCHERFLER (Christopher)</AU>
<AF>MRC Clinical Sciences Centre and Division of Neuroscience, Imperial College/London/Royaume-Uni (1 aut.); Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (1 aut., 2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<LA>Anglais</LA>
<EA>Although Parkinson's disease with later dementia (PDD) and dementia with Lewy bodies (DLB) are pathologically characterized by the presence of intraneuronal Lewy inclusion bodies, amyloid deposition is also associated to varying degrees with both these disorders. Fibrillar amyloid load can now be quantitated in vivo with positron emission tomography (PET) using imaging biomarkers. Here the reported findings of <sup>11</sup>
C-PIB PET studies concerning the amyloid load associated with PD and its influence on dementia are reviewed. It is concluded that the presence of amyloid acts to accelerate the dementia process in Lewy body disorders, though has little influence on its nature. Anti-amyloid strategies could be a relevant approach for slowing dementia in a number of DLB and PDD cases.</EA>
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