MovDisordV3, PascalFrancis, Corpus, bibRecord, 000C66

Apathy May Herald Cognitive Decline and Dementia in Parkinson's Disease

Identifieur interne : 000C66 ( PascalFrancis/Corpus ); précédent : 000C65; suivant : 000C67

Apathy May Herald Cognitive Decline and Dementia in Parkinson's Disease

Auteurs : Kathy Dujardin ; Pascal Sockeel ; Marie Delliaux ; Alain Destee ; Luc Defebvre

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:10-0071255

Descripteurs français

Pascal (Inist)
- Trouble cognitif, Démence, Maladie de Parkinson, Pathologie du système nerveux, Cognition, Noyau gris central, Apathie.

English descriptors

KwdEn :
- Apathy, Basal ganglion, Cognition, Cognitive disorder, Dementia, Nervous system diseases, Parkinson disease.

Abstract

Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18-month follow-up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18-month follow-up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time.
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Format Inist (serveur)

NO :	PASCAL 10-0071255 INIST
ET :	Apathy May Herald Cognitive Decline and Dementia in Parkinson's Disease
AU :	DUJARDIN (Kathy); SOCKEEL (Pascal); DELLIAUX (Marie); DESTEE (Alain); DEFEBVRE (Luc)
AF :	Université Lille Nord de France/France (1 aut., 2 aut., 4 aut., 5 aut.); Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center/Lille/France (1 aut., 3 aut., 4 aut., 5 aut.); Psychology Department/Villeneuve d'Ascq/France (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 16; Pp. 2391-2397; Bibl. 36 ref.
LA :	Anglais
EA :	Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18-month follow-up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time.
CC :	002B17; 002B17G
FD :	Trouble cognitif; Démence; Maladie de Parkinson; Pathologie du système nerveux; Cognition; Noyau gris central; Apathie
FG :	Maladie dégénérative; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central; Encéphale; Système nerveux central
ED :	Cognitive disorder; Dementia; Parkinson disease; Nervous system diseases; Cognition; Basal ganglion; Apathy
EG :	Degenerative disease; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease; Encephalon; Central nervous system
SD :	Trastorno cognitivo; Demencia; Parkinson enfermedad; Sistema nervioso patología; Cognición; Núcleo basal; Apatía
LO :	INIST-20953.354000190005540120
ID :	10-0071255

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Pascal:10-0071255

Le document en format XML

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<front><div type="abstract" xml:lang="en">Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18-month follow-up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time.</div>
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<fC01 i1="01" l="ENG"><s0>Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18-month follow-up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
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<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Cognitive disorder</s0>
<s5>01</s5>
</fC03>
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<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Démence</s0>
<s5>02</s5>
</fC03>
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</fC03>
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<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
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<s5>03</s5>
</fC03>
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<s5>04</s5>
</fC03>
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<fC03 i1="05" i2="X" l="ENG"><s0>Cognition</s0>
<s5>09</s5>
</fC03>
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<s5>10</s5>
</fC03>
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<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Apathie</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Apathy</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Apatía</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
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<s5>37</s5>
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<s5>37</s5>
</fC07>
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<s5>37</s5>
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</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>43</s5>
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<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 10-0071255 INIST</NO>
<ET>Apathy May Herald Cognitive Decline and Dementia in Parkinson's Disease</ET>
<AU>DUJARDIN (Kathy); SOCKEEL (Pascal); DELLIAUX (Marie); DESTEE (Alain); DEFEBVRE (Luc)</AU>
<AF>Université Lille Nord de France/France (1 aut., 2 aut., 4 aut., 5 aut.); Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center/Lille/France (1 aut., 3 aut., 4 aut., 5 aut.); Psychology Department/Villeneuve d'Ascq/France (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 16; Pp. 2391-2397; Bibl. 36 ref.</SO>
<LA>Anglais</LA>
<EA>Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18-month follow-up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time.</EA>
<CC>002B17; 002B17G</CC>
<FD>Trouble cognitif; Démence; Maladie de Parkinson; Pathologie du système nerveux; Cognition; Noyau gris central; Apathie</FD>
<FG>Maladie dégénérative; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central; Encéphale; Système nerveux central</FG>
<ED>Cognitive disorder; Dementia; Parkinson disease; Nervous system diseases; Cognition; Basal ganglion; Apathy</ED>
<EG>Degenerative disease; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease; Encephalon; Central nervous system</EG>
<SD>Trastorno cognitivo; Demencia; Parkinson enfermedad; Sistema nervioso patología; Cognición; Núcleo basal; Apatía</SD>
<LO>INIST-20953.354000190005540120</LO>
<ID>10-0071255</ID>
</server>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Apathy May Herald Cognitive Decline and Dementia in Parkinson's Disease

Apathy May Herald Cognitive Decline and Dementia in Parkinson's Disease

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