DJ-1, PINK 1, and Their Effects on Mitochondrial Pathways
Identifieur interne :
000B93 ( PascalFrancis/Corpus );
précédent :
000B92;
suivant :
000B94
DJ-1, PINK 1, and Their Effects on Mitochondrial Pathways
Auteurs : Mark R. CooksonSource :
-
Movement disorders [ 0885-3185 ] ; 2010.
RBID : Pascal:10-0193450
Descripteurs français
English descriptors
Abstract
Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
| pA |
| A01 | 01 | 1 | | @0 0885-3185 |
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| A03 | | 1 | | @0 Mov. disord. |
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| A05 | | | | @2 25 |
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| A06 | | | | @2 3 @3 SUP1 |
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| A08 | 01 | 1 | ENG | @1 DJ-1, PINK 1, and Their Effects on Mitochondrial Pathways |
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| A09 | 01 | 1 | ENG | @1 Frontiers of Science and Clinical Advances in Quality of Life in Parkinson's Disease |
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| A11 | 01 | 1 | | @1 COOKSON (Mark R.) |
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| A12 | 01 | 1 | | @1 FAHN (Stanley) @9 ed. |
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| A12 | 02 | 1 | | @1 MARDER (Karen) @9 ed. |
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| A12 | 03 | 1 | | @1 COTE (Lucien) @9 ed. |
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| A12 | 04 | 1 | | @1 REICH (Stephen G.) @9 ed. |
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| A14 | 01 | | | @1 Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, NIH @2 Bethesda, Maryland @3 USA @Z 1 aut. |
|---|
| A15 | 01 | | | @1 Department of Neurology, Columbia University College of Physicians and Surgeons @2 New York, New York @3 USA @Z 1 aut. |
|---|
| A18 | 01 | 1 | | @1 Parkinson's Disease Foundation @2 New York, NY @3 USA @9 org-cong. |
|---|
| A20 | | | | @2 S44-S48 |
|---|
| A21 | | | | @1 2010 |
|---|
| A23 | 01 | | | @0 ENG |
|---|
| A43 | 01 | | | @1 INIST @2 20953 @5 354000189676130060 |
|---|
| A44 | | | | @0 0000 @1 © 2010 INIST-CNRS. All rights reserved. |
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| A45 | | | | @0 77 ref. |
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| A47 | 01 | 1 | | @0 10-0193450 |
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| A60 | | | | @1 P @2 C |
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| A61 | | | | @0 A |
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| A64 | 01 | 1 | | @0 Movement disorders |
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| A66 | 01 | | | @0 USA |
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| C01 | 01 | | ENG | @0 Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD. |
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| C02 | 01 | X | | @0 002B17 |
|---|
| C02 | 02 | X | | @0 002B02B10 |
|---|
| C03 | 01 | X | FRE | @0 Parkinsonisme @2 NM @5 01 |
|---|
| C03 | 01 | X | ENG | @0 Parkinsonism @2 NM @5 01 |
|---|
| C03 | 01 | X | SPA | @0 Parkinson síndrome @2 NM @5 01 |
|---|
| C03 | 02 | X | FRE | @0 Pathologie du système nerveux @5 02 |
|---|
| C03 | 02 | X | ENG | @0 Nervous system diseases @5 02 |
|---|
| C03 | 02 | X | SPA | @0 Sistema nervioso patología @5 02 |
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| C03 | 03 | X | FRE | @0 Mitochondrie @5 09 |
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| C03 | 03 | X | ENG | @0 Mitochondria @5 09 |
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| C03 | 03 | X | SPA | @0 Mitocondria @5 09 |
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| C03 | 04 | X | FRE | @0 Parkine @5 10 |
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| C03 | 04 | X | ENG | @0 Parkin @5 10 |
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| C03 | 04 | X | SPA | @0 Parkin @5 10 |
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| N21 | | | | @1 130 |
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| N44 | 01 | | | @1 OTO |
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| N82 | | | | @1 OTO |
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| pR |
| A30 | 01 | 1 | ENG | @1 Symposium of the Parkinson's Disease Foundation @3 South Street Seaport, Manhattan USA @4 2007-10-11 |
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|
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Format Inist (serveur)
| NO : | PASCAL 10-0193450 INIST |
|---|
| ET : | DJ-1, PINK 1, and Their Effects on Mitochondrial Pathways |
|---|
| AU : | COOKSON (Mark R.); FAHN (Stanley); MARDER (Karen); COTE (Lucien); REICH (Stephen G.) |
|---|
| AF : | Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, NIH/Bethesda, Maryland/Etats-Unis (1 aut.); Department of Neurology, Columbia University College of Physicians and Surgeons/New York, New York/Etats-Unis (1 aut.) |
|---|
| DT : | Publication en série; Congrès; Niveau analytique |
|---|
| SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 3 SUP1; S44-S48; Bibl. 77 ref. |
|---|
| LA : | Anglais |
|---|
| EA : | Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD. |
|---|
| CC : | 002B17; 002B02B10 |
|---|
| FD : | Parkinsonisme; Pathologie du système nerveux; Mitochondrie; Parkine |
|---|
| ED : | Parkinsonism; Nervous system diseases; Mitochondria; Parkin |
|---|
| SD : | Parkinson síndrome; Sistema nervioso patología; Mitocondria; Parkin |
|---|
| LO : | INIST-20953.354000189676130060 |
|---|
| ID : | 10-0193450 |
|---|
Links to Exploration step
Pascal:10-0193450
Le document en format XML
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