Imaging Essential Tremor
Identifieur interne : 000B64 ( PascalFrancis/Corpus ); précédent : 000B63; suivant : 000B65Imaging Essential Tremor
Auteurs : Ioannis U. Isaias ; Giorgio Marotta ; Shigeki Hirano ; Margherita Canesi ; Riccardo Benti ; Andrea Righini ; CHENGKE TANG ; Roberto Cilia ; Gianni Pezzoli ; David Eidelberg ; Angelo AntoniniSource :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [99mTc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 10-0233093 INIST |
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ET : | Imaging Essential Tremor |
AU : | ISAIAS (Ioannis U.); MAROTTA (Giorgio); HIRANO (Shigeki); CANESI (Margherita); BENTI (Riccardo); RIGHINI (Andrea); CHENGKE TANG; CILIA (Roberto); PEZZOLI (Gianni); EIDELBERG (David); ANTONINI (Angelo) |
AF : | Department of Human Physiology, University of Milano/Milano/Italie (1 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (1 aut., 4 aut., 8 aut., 9 aut., 11 aut.); Nuclear Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico/Milano/Italie (2 aut., 5 aut.); Center for Neurosciences, The Feinstein Institute for Medical Research/Manhasset, New York/Etats-Unis (3 aut., 7 aut., 10 aut.); Neuroradiology Department, V. Buzzi Hospital/Milano/Italie (6 aut.); Departments of Neurology and Medicine, North Shore University Hospital, North Shore-LIJ Health System/Manhasset, New York/Etats-Unis (10 aut.); Institute of Neurology, IRCCS San Camillo, Venice and University of Padua/Italie (11 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 6; Pp. 679-686; Bibl. 44 ref. |
LA : | Anglais |
EA : | To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [99mTc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET. |
CC : | 002B17; 002B24A06 |
FD : | Tremblement; Pathologie du système nerveux; Tomoscintigraphie émission monophotonique; Photon |
FG : | Mouvement involontaire; Trouble neurologique |
ED : | Tremor; Nervous system diseases; Single photon emission tomography; Photon |
EG : | Involuntary movement; Neurological disorder |
SD : | Temblor; Sistema nervioso patología; Tomografía emisión fotón único; Fotón |
LO : | INIST-20953.354000181078480030 |
ID : | 10-0233093 |
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Pascal:10-0233093Le document en format XML
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [<sup>99m</sup>
Tc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.</div>
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Tc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.</s0>
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<server><NO>PASCAL 10-0233093 INIST</NO>
<ET>Imaging Essential Tremor</ET>
<AU>ISAIAS (Ioannis U.); MAROTTA (Giorgio); HIRANO (Shigeki); CANESI (Margherita); BENTI (Riccardo); RIGHINI (Andrea); CHENGKE TANG; CILIA (Roberto); PEZZOLI (Gianni); EIDELBERG (David); ANTONINI (Angelo)</AU>
<AF>Department of Human Physiology, University of Milano/Milano/Italie (1 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (1 aut., 4 aut., 8 aut., 9 aut., 11 aut.); Nuclear Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico/Milano/Italie (2 aut., 5 aut.); Center for Neurosciences, The Feinstein Institute for Medical Research/Manhasset, New York/Etats-Unis (3 aut., 7 aut., 10 aut.); Neuroradiology Department, V. Buzzi Hospital/Milano/Italie (6 aut.); Departments of Neurology and Medicine, North Shore University Hospital, North Shore-LIJ Health System/Manhasset, New York/Etats-Unis (10 aut.); Institute of Neurology, IRCCS San Camillo, Venice and University of Padua/Italie (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 6; Pp. 679-686; Bibl. 44 ref.</SO>
<LA>Anglais</LA>
<EA>To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [<sup>99m</sup>
Tc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.</EA>
<CC>002B17; 002B24A06</CC>
<FD>Tremblement; Pathologie du système nerveux; Tomoscintigraphie émission monophotonique; Photon</FD>
<FG>Mouvement involontaire; Trouble neurologique</FG>
<ED>Tremor; Nervous system diseases; Single photon emission tomography; Photon</ED>
<EG>Involuntary movement; Neurological disorder</EG>
<SD>Temblor; Sistema nervioso patología; Tomografía emisión fotón único; Fotón</SD>
<LO>INIST-20953.354000181078480030</LO>
<ID>10-0233093</ID>
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