MovDisordV3, PascalFrancis, Corpus, bibRecord, 000B64

Imaging Essential Tremor

Identifieur interne : 000B64 ( PascalFrancis/Corpus ); précédent : 000B63; suivant : 000B65

Imaging Essential Tremor

Auteurs : Ioannis U. Isaias ; Giorgio Marotta ; Shigeki Hirano ; Margherita Canesi ; Riccardo Benti ; Andrea Righini ; CHENGKE TANG ; Roberto Cilia ; Gianni Pezzoli ; David Eidelberg ; Angelo Antonini

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0233093

Descripteurs français

Pascal (Inist)
- Tremblement, Pathologie du système nerveux, Tomoscintigraphie émission monophotonique, Photon.

English descriptors

KwdEn :
- Nervous system diseases, Photon, Single photon emission tomography, Tremor.

Abstract

To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [^99mTc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A05				`@2 25`
A06				`@2 6`
A08	`01`	`1`	`ENG`	`@1 Imaging Essential Tremor`
A11	`01`	`1`		`@1 ISAIAS (Ioannis U.)`
A11	`02`	`1`		`@1 MAROTTA (Giorgio)`
A11	`03`	`1`		`@1 HIRANO (Shigeki)`
A11	`04`	`1`		`@1 CANESI (Margherita)`
A11	`05`	`1`		`@1 BENTI (Riccardo)`
A11	`06`	`1`		`@1 RIGHINI (Andrea)`
A11	`07`	`1`		`@1 CHENGKE TANG`
A11	`08`	`1`		`@1 CILIA (Roberto)`
A11	`09`	`1`		`@1 PEZZOLI (Gianni)`
A11	`10`	`1`		`@1 EIDELBERG (David)`
A11	`11`	`1`		`@1 ANTONINI (Angelo)`
A14	`01`			`@1 Department of Human Physiology, University of Milano @2 Milano @3 ITA @Z 1 aut.`
A14	`02`			`@1 Parkinson Institute, Istituti Clinici di Perfezionamento @2 Milano @3 ITA @Z 1 aut. @Z 4 aut. @Z 8 aut. @Z 9 aut. @Z 11 aut.`
A14	`03`			`@1 Nuclear Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico @2 Milano @3 ITA @Z 2 aut. @Z 5 aut.`
A14	`04`			`@1 Center for Neurosciences, The Feinstein Institute for Medical Research @2 Manhasset, New York @3 USA @Z 3 aut. @Z 7 aut. @Z 10 aut.`
A14	`05`			`@1 Neuroradiology Department, V. Buzzi Hospital @2 Milano @3 ITA @Z 6 aut.`
A14	`06`			`@1 Departments of Neurology and Medicine, North Shore University Hospital, North Shore-LIJ Health System @2 Manhasset, New York @3 USA @Z 10 aut.`
A14	`07`			`@1 Institute of Neurology, IRCCS San Camillo, Venice and University of Padua @3 ITA @Z 11 aut.`
A20				`@1 679-686`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000181078480030`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 44 ref.`
A47	`01`	`1`		`@0 10-0233093`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [^99mTc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B24A06`
C03	`01`	`X`	`FRE`	`@0 Tremblement @5 01`
C03	`01`	`X`	`ENG`	`@0 Tremor @5 01`
C03	`01`	`X`	`SPA`	`@0 Temblor @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Tomoscintigraphie émission monophotonique @5 09`
C03	`03`	`X`	`ENG`	`@0 Single photon emission tomography @5 09`
C03	`03`	`X`	`SPA`	`@0 Tomografía emisión fotón único @5 09`
C03	`04`	`X`	`FRE`	`@0 Photon @5 10`
C03	`04`	`X`	`ENG`	`@0 Photon @5 10`
C03	`04`	`X`	`SPA`	`@0 Fotón @5 10`
C07	`01`	`X`	`FRE`	`@0 Mouvement involontaire @5 37`
C07	`01`	`X`	`ENG`	`@0 Involuntary movement @5 37`
C07	`01`	`X`	`SPA`	`@0 Movimiento involuntario @5 37`
C07	`02`	`X`	`FRE`	`@0 Trouble neurologique @5 39`
C07	`02`	`X`	`ENG`	`@0 Neurological disorder @5 39`
C07	`02`	`X`	`SPA`	`@0 Trastorno neurológico @5 39`
N21				`@1 158`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0233093 INIST
ET :	Imaging Essential Tremor
AU :	ISAIAS (Ioannis U.); MAROTTA (Giorgio); HIRANO (Shigeki); CANESI (Margherita); BENTI (Riccardo); RIGHINI (Andrea); CHENGKE TANG; CILIA (Roberto); PEZZOLI (Gianni); EIDELBERG (David); ANTONINI (Angelo)
AF :	Department of Human Physiology, University of Milano/Milano/Italie (1 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (1 aut., 4 aut., 8 aut., 9 aut., 11 aut.); Nuclear Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico/Milano/Italie (2 aut., 5 aut.); Center for Neurosciences, The Feinstein Institute for Medical Research/Manhasset, New York/Etats-Unis (3 aut., 7 aut., 10 aut.); Neuroradiology Department, V. Buzzi Hospital/Milano/Italie (6 aut.); Departments of Neurology and Medicine, North Shore University Hospital, North Shore-LIJ Health System/Manhasset, New York/Etats-Unis (10 aut.); Institute of Neurology, IRCCS San Camillo, Venice and University of Padua/Italie (11 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 6; Pp. 679-686; Bibl. 44 ref.
LA :	Anglais
EA :	To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [^99mTc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.
CC :	002B17; 002B24A06
FD :	Tremblement; Pathologie du système nerveux; Tomoscintigraphie émission monophotonique; Photon
FG :	Mouvement involontaire; Trouble neurologique
ED :	Tremor; Nervous system diseases; Single photon emission tomography; Photon
EG :	Involuntary movement; Neurological disorder
SD :	Temblor; Sistema nervioso patología; Tomografía emisión fotón único; Fotón
LO :	INIST-20953.354000181078480030
ID :	10-0233093

Links to Exploration step

Pascal:10-0233093

Le document en format XML

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<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
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<s2>Milano</s2>
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<author><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name>
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<s2>Milano</s2>
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<author><name sortKey="Righini, Andrea" sort="Righini, Andrea" uniqKey="Righini A" first="Andrea" last="Righini">Andrea Righini</name>
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<author><name sortKey="Chengke Tang" sort="Chengke Tang" uniqKey="Chengke Tang" last="Chengke Tang">CHENGKE TANG</name>
<affiliation><inist:fA14 i1="04"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, New York</s2>
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<author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name>
<affiliation><inist:fA14 i1="02"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
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<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
<affiliation><inist:fA14 i1="02"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
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<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<affiliation><inist:fA14 i1="04"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, New York</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="06"><s1>Departments of Neurology and Medicine, North Shore University Hospital, North Shore-LIJ Health System</s1>
<s2>Manhasset, New York</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
<affiliation><inist:fA14 i1="02"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="07"><s1>Institute of Neurology, IRCCS San Camillo, Venice and University of Padua</s1>
<s3>ITA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
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<front><div type="abstract" xml:lang="en">To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [<sup>99m</sup>
Tc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.</div>
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<ET>Imaging Essential Tremor</ET>
<AU>ISAIAS (Ioannis U.); MAROTTA (Giorgio); HIRANO (Shigeki); CANESI (Margherita); BENTI (Riccardo); RIGHINI (Andrea); CHENGKE TANG; CILIA (Roberto); PEZZOLI (Gianni); EIDELBERG (David); ANTONINI (Angelo)</AU>
<AF>Department of Human Physiology, University of Milano/Milano/Italie (1 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (1 aut., 4 aut., 8 aut., 9 aut., 11 aut.); Nuclear Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico/Milano/Italie (2 aut., 5 aut.); Center for Neurosciences, The Feinstein Institute for Medical Research/Manhasset, New York/Etats-Unis (3 aut., 7 aut., 10 aut.); Neuroradiology Department, V. Buzzi Hospital/Milano/Italie (6 aut.); Departments of Neurology and Medicine, North Shore University Hospital, North Shore-LIJ Health System/Manhasset, New York/Etats-Unis (10 aut.); Institute of Neurology, IRCCS San Camillo, Venice and University of Padua/Italie (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<EA>To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [<sup>99m</sup>
Tc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akineticrigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.</EA>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Imaging Essential Tremor

Imaging Essential Tremor

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