Hyposmia in Progressive Supranuclear Palsy
Identifieur interne : 000B43 ( PascalFrancis/Corpus ); précédent : 000B42; suivant : 000B44Hyposmia in Progressive Supranuclear Palsy
Auteurs : Laura Silveira-Moriyama ; Graham Hughes ; Alistair Church ; Hilary Ayling ; David R. Williams ; Aviva Petrie ; Janice Holton ; Tamas Revesz ; Ann Kingsbury ; Huw R. Morris ; David J. Burn ; Andrew J. LeesSource :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 10-0233212 INIST |
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ET : | Hyposmia in Progressive Supranuclear Palsy |
AU : | SILVEIRA-MORIYAMA (Laura); HUGHES (Graham); CHURCH (Alistair); AYLING (Hilary); WILLIAMS (David R.); PETRIE (Aviva); HOLTON (Janice); REVESZ (Tamas); KINGSBURY (Ann); MORRIS (Huw R.); BURN (David J.); LEES (Andrew J.) |
AF : | Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology/London/Royaume-Uni (1 aut., 5 aut., 7 aut., 9 aut., 12 aut.); Institute for Ageing and Health, Newcastle University/Newcastle Upon Tyne/Royaume-Uni (2 aut., 11 aut.); Department of Neurology, Royal Gwent Hospital, Newport/Gwent/Royaume-Uni (3 aut.); Queen Square Brain Bank, UCL Institute of Neurology/London/Royaume-Uni (4 aut., 7 aut., 8 aut., 12 aut.); Department of Neurology, Faculty of Medicine (Neurosciences), Monash University (Alfred Hospital Campus)/Melbourne/Australie (5 aut.); Biostatistics Unit, UCL Eastman Dental Institute/London/Royaume-Uni (6 aut.); Department of Neurology, Cardiff University School of Medicine, Cardiff University/Cardiff/Royaume-Uni (10 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 5; Pp. 570-577; Bibl. 41 ref. |
LA : | Anglais |
EA : | Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. |
CC : | 002B17; 002B17G |
FD : | Trouble de l'odorat; Maladie de Parkinson; Pathologie du système nerveux; Ophtalmoplégie supranucléaire; Postmortem; Olfaction |
FG : | Trouble neurologique; Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral; Syndrome extrapyramidal |
ED : | Olfactory disorder; Parkinson disease; Nervous system diseases; Supranuclear ophthalmoplegia; Postmortem; Olfaction |
EG : | Neurological disorder; Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Extrapyramidal syndrome |
SD : | Trastorno olfatorio; Parkinson enfermedad; Sistema nervioso patología; Oftalmoplejía supranuclear; Postmortem; Olfación |
LO : | INIST-20953.354000181079390080 |
ID : | 10-0233212 |
Links to Exploration step
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP.</div>
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<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, Faculty of Medicine (Neurosciences), Monash University (Alfred Hospital Campus)</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Biostatistics Unit, UCL Eastman Dental Institute</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurology, Cardiff University School of Medicine, Cardiff University</s1>
<s2>Cardiff</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA20><s1>570-577</s1>
</fA20>
<fA21><s1>2010</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000181079390080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>41 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>10-0233212</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Trouble de l'odorat</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Olfactory disorder</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Trastorno olfatorio</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Ophtalmoplégie supranucléaire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Supranuclear ophthalmoplegia</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Oftalmoplejía supranuclear</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Postmortem</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Postmortem</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Postmortem</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Olfaction</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Olfaction</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Olfación</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Syndrome oculomoteur</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Oculomotor syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Oculomotricidad síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie de l'oeil</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Eye disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Ojo patología</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Syndrome du tronc cérébral</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Brain stem syndrome</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Tallo encefalico sindrome</s0>
<s5>44</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>45</s5>
</fC07>
<fN21><s1>158</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 10-0233212 INIST</NO>
<ET>Hyposmia in Progressive Supranuclear Palsy</ET>
<AU>SILVEIRA-MORIYAMA (Laura); HUGHES (Graham); CHURCH (Alistair); AYLING (Hilary); WILLIAMS (David R.); PETRIE (Aviva); HOLTON (Janice); REVESZ (Tamas); KINGSBURY (Ann); MORRIS (Huw R.); BURN (David J.); LEES (Andrew J.)</AU>
<AF>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology/London/Royaume-Uni (1 aut., 5 aut., 7 aut., 9 aut., 12 aut.); Institute for Ageing and Health, Newcastle University/Newcastle Upon Tyne/Royaume-Uni (2 aut., 11 aut.); Department of Neurology, Royal Gwent Hospital, Newport/Gwent/Royaume-Uni (3 aut.); Queen Square Brain Bank, UCL Institute of Neurology/London/Royaume-Uni (4 aut., 7 aut., 8 aut., 12 aut.); Department of Neurology, Faculty of Medicine (Neurosciences), Monash University (Alfred Hospital Campus)/Melbourne/Australie (5 aut.); Biostatistics Unit, UCL Eastman Dental Institute/London/Royaume-Uni (6 aut.); Department of Neurology, Cardiff University School of Medicine, Cardiff University/Cardiff/Royaume-Uni (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 5; Pp. 570-577; Bibl. 41 ref.</SO>
<LA>Anglais</LA>
<EA>Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP.</EA>
<CC>002B17; 002B17G</CC>
<FD>Trouble de l'odorat; Maladie de Parkinson; Pathologie du système nerveux; Ophtalmoplégie supranucléaire; Postmortem; Olfaction</FD>
<FG>Trouble neurologique; Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral; Syndrome extrapyramidal</FG>
<ED>Olfactory disorder; Parkinson disease; Nervous system diseases; Supranuclear ophthalmoplegia; Postmortem; Olfaction</ED>
<EG>Neurological disorder; Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Extrapyramidal syndrome</EG>
<SD>Trastorno olfatorio; Parkinson enfermedad; Sistema nervioso patología; Oftalmoplejía supranuclear; Postmortem; Olfación</SD>
<LO>INIST-20953.354000181079390080</LO>
<ID>10-0233212</ID>
</server>
</inist>
</record>
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