Mild Parkinsonian Signs Are Associated With Increased Risk of Dementia in a Prospective, Population-Based Study of Elders
Identifieur interne : 000A82 ( PascalFrancis/Corpus ); précédent : 000A81; suivant : 000A83Mild Parkinsonian Signs Are Associated With Increased Risk of Dementia in a Prospective, Population-Based Study of Elders
Auteurs : Elan D. Louis ; Ming X. Tang ; Nicole SchupfSource :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P < 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HRaxial days-function = 2.45 (P < 0.001), adjusted HRtremor = 2.38 (P = 0.006), and adjusted HRrigidity = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia.
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pA |
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Format Inist (serveur)
NO : | PASCAL 10-0303304 INIST |
---|---|
ET : | Mild Parkinsonian Signs Are Associated With Increased Risk of Dementia in a Prospective, Population-Based Study of Elders |
AU : | LOUIS (Elan D.); TANG (Ming X.); SCHUPF (Nicole) |
AF : | GH Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Epidemiology, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (1 aut., 3 aut.); Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 3 aut.); Department of Biostatistics, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (2 aut.); Department of Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 2; Pp. 172-178; Bibl. 45 ref. |
LA : | Anglais |
EA : | There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P < 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HRaxial days-function = 2.45 (P < 0.001), adjusted HRtremor = 2.38 (P = 0.006), and adjusted HRrigidity = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Démence d'Alzheimer; Pathologie du système nerveux; Signe; Facteur risque; Prospective; Personne âgée; Epidémiologie |
FG : | Homme; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Alzheimer disease; Nervous system diseases; Sign; Risk factor; Prospective; Elderly; Epidemiology |
EG : | Human; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Demencia Alzheimer; Sistema nervioso patología; Signo; Factor riesgo; Prospectiva; Anciano; Epidemiología |
LO : | INIST-20953.354000170495040050 |
ID : | 10-0303304 |
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Pascal:10-0303304Le document en format XML
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<front><div type="abstract" xml:lang="en">There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P < 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HR<sub>axial</sub>
days-function <sup>=</sup>
2.45 (P < 0.001), adjusted HR<sub>tremor</sub>
<sub>=</sub>
2.38 (P <sub>=</sub>
0.006), and adjusted HR<sub>rigidity</sub>
= 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia.</div>
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<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>193</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 10-0303304 INIST</NO>
<ET>Mild Parkinsonian Signs Are Associated With Increased Risk of Dementia in a Prospective, Population-Based Study of Elders</ET>
<AU>LOUIS (Elan D.); TANG (Ming X.); SCHUPF (Nicole)</AU>
<AF>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Epidemiology, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (1 aut., 3 aut.); Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 3 aut.); Department of Biostatistics, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (2 aut.); Department of Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 2; Pp. 172-178; Bibl. 45 ref.</SO>
<LA>Anglais</LA>
<EA>There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P < 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HR<sub>axial</sub>
days-function <sup>=</sup>
2.45 (P < 0.001), adjusted HR<sub>tremor</sub>
<sub>=</sub>
2.38 (P <sub>=</sub>
0.006), and adjusted HR<sub>rigidity</sub>
= 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Démence d'Alzheimer; Pathologie du système nerveux; Signe; Facteur risque; Prospective; Personne âgée; Epidémiologie</FD>
<FG>Homme; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Alzheimer disease; Nervous system diseases; Sign; Risk factor; Prospective; Elderly; Epidemiology</ED>
<EG>Human; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Demencia Alzheimer; Sistema nervioso patología; Signo; Factor riesgo; Prospectiva; Anciano; Epidemiología</SD>
<LO>INIST-20953.354000170495040050</LO>
<ID>10-0303304</ID>
</server>
</inist>
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