MovDisordV3, PascalFrancis, Corpus, bibRecord, 000A17

Endoscopic Characteristics and Levodopa Responsiveness of Swallowing Function in Progressive Supranuclear Palsy

Identifieur interne : 000A17 ( PascalFrancis/Corpus ); précédent : 000A16; suivant : 000A18

Endoscopic Characteristics and Levodopa Responsiveness of Swallowing Function in Progressive Supranuclear Palsy

Auteurs : Tobias Warnecke ; Stephan Oelenberg ; Inga Teismann ; Christina Hamacher ; Hubertus Lohmann ; Erich Bernd Ringelstein ; Rainer Dziewas

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0376237

Descripteurs français

Pascal (Inist)
- Dysphagie, Pathologie du système nerveux, Endoscopie, Lévodopa, Déglutition, Ophtalmoplégie supranucléaire, Honoraires.

English descriptors

KwdEn :
- Dysphagia, Endoscopy, Fees, Levodopa, Nervous system diseases, Supranuclear ophthalmoplegia, Swallowing.

Abstract

Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES") has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES® to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 ± 9.0 years) were included. The salient findings of FEES in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES® protocol was performed to explore levodopa (L-dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES® were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L-dopa challenge. Chin tuck-maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES® assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 WARNECKE (Tobias)`
A11	`02`	`1`		`@1 OELENBERG (Stephan)`
A11	`03`	`1`		`@1 TEISMANN (Inga)`
A11	`04`	`1`		`@1 HAMACHER (Christina)`
A11	`05`	`1`		`@1 LOHMANN (Hubertus)`
A11	`06`	`1`		`@1 BERND RINGELSTEIN (Erich)`
A11	`07`	`1`		`@1 DZIEWAS (Rainer)`
A14	`01`			`@1 Department of Neurology, University Hospital of Münster @2 Münster @3 DEU @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut.`
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A43	`01`			`@1 INIST @2 20953 @5 354000191760240190`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 33 ref.`
A47	`01`	`1`		`@0 10-0376237`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES") has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES® to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 ± 9.0 years) were included. The salient findings of FEES in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES® protocol was performed to explore levodopa (L-dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES® were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L-dopa challenge. Chin tuck-maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES® assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B02U01`
C03	`01`	`X`	`FRE`	`@0 Dysphagie @5 01`
C03	`01`	`X`	`ENG`	`@0 Dysphagia @5 01`
C03	`01`	`X`	`SPA`	`@0 Disfagia @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Endoscopie @5 09`
C03	`03`	`X`	`ENG`	`@0 Endoscopy @5 09`
C03	`03`	`X`	`SPA`	`@0 Endoscopía @5 09`
C03	`04`	`X`	`FRE`	`@0 Lévodopa @2 NK @2 FR @5 10`
C03	`04`	`X`	`ENG`	`@0 Levodopa @2 NK @2 FR @5 10`
C03	`04`	`X`	`SPA`	`@0 Levodopa @2 NK @2 FR @5 10`
C03	`05`	`X`	`FRE`	`@0 Déglutition @5 11`
C03	`05`	`X`	`ENG`	`@0 Swallowing @5 11`
C03	`05`	`X`	`SPA`	`@0 Deglutición @5 11`
C03	`06`	`X`	`FRE`	`@0 Ophtalmoplégie supranucléaire @5 12`
C03	`06`	`X`	`ENG`	`@0 Supranuclear ophthalmoplegia @5 12`
C03	`06`	`X`	`SPA`	`@0 Oftalmoplejía supranuclear @5 12`
C03	`07`	`X`	`FRE`	`@0 Honoraires @5 13`
C03	`07`	`X`	`ENG`	`@0 Fees @5 13`
C03	`07`	`X`	`SPA`	`@0 Honorarios @5 13`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Maladie dégénérative @5 38`
C07	`02`	`X`	`ENG`	`@0 Degenerative disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome oculomoteur @5 39`
C07	`03`	`X`	`ENG`	`@0 Oculomotor syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Oculomotricidad síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie de l'oeil @5 40`
C07	`04`	`X`	`ENG`	`@0 Eye disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Ojo patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
C07	`06`	`X`	`FRE`	`@0 Syndrome du tronc cérébral @5 43`
C07	`06`	`X`	`ENG`	`@0 Brain stem syndrome @5 43`
C07	`06`	`X`	`SPA`	`@0 Tallo encefalico sindrome @5 43`
C07	`07`	`X`	`FRE`	`@0 Pathologie de l'appareil digestif @5 44`
C07	`07`	`X`	`ENG`	`@0 Digestive diseases @5 44`
C07	`07`	`X`	`SPA`	`@0 Aparato digestivo patología @5 44`
C07	`08`	`X`	`FRE`	`@0 Pathologie de l'oesophage @5 45`
C07	`08`	`X`	`ENG`	`@0 Esophageal disease @5 45`
C07	`08`	`X`	`SPA`	`@0 Esófago patología @5 45`
C07	`09`	`X`	`FRE`	`@0 Pathologie ORL @5 46`
C07	`09`	`X`	`ENG`	`@0 ENT disease @5 46`
C07	`09`	`X`	`SPA`	`@0 ORL patología @5 46`
N21				`@1 242`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0376237 INIST
ET :	Endoscopic Characteristics and Levodopa Responsiveness of Swallowing Function in Progressive Supranuclear Palsy
AU :	WARNECKE (Tobias); OELENBERG (Stephan); TEISMANN (Inga); HAMACHER (Christina); LOHMANN (Hubertus); BERND RINGELSTEIN (Erich); DZIEWAS (Rainer)
AF :	Department of Neurology, University Hospital of Münster/Münster/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 9; Pp. 1239-1245; Bibl. 33 ref.
LA :	Anglais
EA :	Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES") has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES® to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 ± 9.0 years) were included. The salient findings of FEES in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES® protocol was performed to explore levodopa (L-dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES® were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L-dopa challenge. Chin tuck-maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES® assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients.
CC :	002B17; 002B02U01
FD :	Dysphagie; Pathologie du système nerveux; Endoscopie; Lévodopa; Déglutition; Ophtalmoplégie supranucléaire; Honoraires
FG :	Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral; Pathologie de l'appareil digestif; Pathologie de l'oesophage; Pathologie ORL
ED :	Dysphagia; Nervous system diseases; Endoscopy; Levodopa; Swallowing; Supranuclear ophthalmoplegia; Fees
EG :	Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Digestive diseases; Esophageal disease; ENT disease
SD :	Disfagia; Sistema nervioso patología; Endoscopía; Levodopa; Deglutición; Oftalmoplejía supranuclear; Honorarios
LO :	INIST-20953.354000191760240190
ID :	10-0376237

Links to Exploration step

Pascal:10-0376237

Le document en format XML

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<front><div type="abstract" xml:lang="en">Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES") has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES® to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 ± 9.0 years) were included. The salient findings of FEES in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES® protocol was performed to explore levodopa (L-dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES® were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L-dopa challenge. Chin tuck-maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES® assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients.</div>
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<server><NO>PASCAL 10-0376237 INIST</NO>
<ET>Endoscopic Characteristics and Levodopa Responsiveness of Swallowing Function in Progressive Supranuclear Palsy</ET>
<AU>WARNECKE (Tobias); OELENBERG (Stephan); TEISMANN (Inga); HAMACHER (Christina); LOHMANN (Hubertus); BERND RINGELSTEIN (Erich); DZIEWAS (Rainer)</AU>
<AF>Department of Neurology, University Hospital of Münster/Münster/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<EA>Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES") has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES® to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 ± 9.0 years) were included. The salient findings of FEES in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES® protocol was performed to explore levodopa (L-dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES® were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L-dopa challenge. Chin tuck-maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES® assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients.</EA>
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<FD>Dysphagie; Pathologie du   système nerveux; Endoscopie; Lévodopa; Déglutition; Ophtalmoplégie supranucléaire; Honoraires</FD>
<FG>Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du   système nerveux central; Syndrome du tronc cérébral; Pathologie de l'appareil digestif; Pathologie de l'oesophage; Pathologie ORL</FG>
<ED>Dysphagia; Nervous system diseases; Endoscopy; Levodopa; Swallowing; Supranuclear ophthalmoplegia; Fees</ED>
<EG>Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Digestive diseases; Esophageal disease; ENT disease</EG>
<SD>Disfagia; Sistema nervioso patología; Endoscopía; Levodopa; Deglutición; Oftalmoplejía supranuclear; Honorarios</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Endoscopic Characteristics and Levodopa Responsiveness of Swallowing Function in Progressive Supranuclear Palsy

Endoscopic Characteristics and Levodopa Responsiveness of Swallowing Function in Progressive Supranuclear Palsy

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