MovDisordV3, PascalFrancis, Corpus, bibRecord, 000961

Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease

Identifieur interne : 000961 ( PascalFrancis/Corpus ); précédent : 000960; suivant : 000962

Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease

Auteurs : Christine Daniels ; Paul Krack ; Jens Volkmann ; Markus O. Pinsker ; Martin Krause ; Volker Tronnier ; Manja Kloss ; Alfons Schnitzler ; Lars Wojtecki ; Kai Bötzel ; Adrian Danek ; Rüdiger Hilker ; Volker Sturm ; Andreas Kupsch ; Elfriede Karner ; Günther Deuschl ; Karsten Witt

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0413277

Descripteurs français

Pascal (Inist)
- Trouble cognitif, Maladie de Parkinson, Pathologie du système nerveux, Facteur risque, Noyau sousthalamique.

English descriptors

KwdEn :
- Cognitive disorder, Nervous system diseases, Parkinson disease, Risk factor, Subthalamic nucleus.

Abstract

A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains "global cognitive functioning," "memory," "working memory," "attention," and "executive function." These domain-specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN-DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa-equivalence dosage (LED) and axial subscore of the UPDRS in the off-medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN-DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN-DBS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 KRACK (Paul)`
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A11	`04`	`1`		`@1 PINSKER (Markus O.)`
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A11	`06`	`1`		`@1 TRONNIER (Volker)`
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A11	`11`	`1`		`@1 DANEK (Adrian)`
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A11	`13`	`1`		`@1 STURM (Volker)`
A11	`14`	`1`		`@1 KUPSCH (Andreas)`
A11	`15`	`1`		`@1 KARNER (Elfriede)`
A11	`16`	`1`		`@1 DEUSCHL (Günther)`
A11	`17`	`1`		`@1 WITT (Karsten)`
A14	`01`			`@1 Department of Neurology, Christian-Albrechts-University @2 Kiel @3 DEU @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 16 aut. @Z 17 aut.`
A14	`02`			`@1 Department of Neurosurgery, Christian-Albrechts-University @2 Kiel @3 DEU @Z 4 aut.`
A14	`03`			`@1 Department of Neurology, Heidelberg University @2 Heidelberg @3 DEU @Z 5 aut. @Z 7 aut.`
A14	`04`			`@1 Department of Neurosurgery, Heidelberg University @2 Heidelberg @3 DEU @Z 6 aut.`
A14	`05`			`@1 Department of Neurology, Heinrich Heine University @2 Dusseldorf @3 DEU @Z 8 aut. @Z 9 aut.`
A14	`06`			`@1 Department of Neurology, Ludwig-Maximilians-University @2 Munich @3 DEU @Z 10 aut. @Z 11 aut.`
A14	`07`			`@1 Department of Neurology, Cologne University @2 Cologne @3 DEU @Z 12 aut.`
A14	`08`			`@1 Department of Neurosurgery, Cologne University @2 Cologne @3 DEU @Z 13 aut.`
A14	`09`			`@1 Department of Neurology, Charité Hospital, Humboldt University @2 Berlin @3 DEU @Z 14 aut.`
A14	`10`			`@1 Department of Neurology, Innsbruck Medical University @2 Innsbruck @3 AUT @Z 15 aut.`
A20				`@1 1583-1589`
A21				`@1 2010`
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A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
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A61				`@0 A`
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C01	`01`		`ENG`	@0 A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains "global cognitive functioning," "memory," "working memory," "attention," and "executive function." These domain-specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN-DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa-equivalence dosage (LED) and axial subscore of the UPDRS in the off-medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN-DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN-DBS.
C02	`01`	`X`		`@0 002B17`
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C03	`01`	`X`	`FRE`	`@0 Trouble cognitif @5 01`
C03	`01`	`X`	`ENG`	`@0 Cognitive disorder @5 01`
C03	`01`	`X`	`SPA`	`@0 Trastorno cognitivo @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Facteur risque @5 09`
C03	`04`	`X`	`ENG`	`@0 Risk factor @5 09`
C03	`04`	`X`	`SPA`	`@0 Factor riesgo @5 09`
C03	`05`	`X`	`FRE`	`@0 Noyau sousthalamique @5 10`
C03	`05`	`X`	`ENG`	`@0 Subthalamic nucleus @5 10`
C03	`05`	`X`	`SPA`	`@0 Núcleo subtalámico @5 10`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 42`
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Format Inist (serveur)

NO :	PASCAL 10-0413277 INIST
ET :	Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease
AU :	DANIELS (Christine); KRACK (Paul); VOLKMANN (Jens); PINSKER (Markus O.); KRAUSE (Martin); TRONNIER (Volker); KLOSS (Manja); SCHNITZLER (Alfons); WOJTECKI (Lars); BÖTZEL (Kai); DANEK (Adrian); HILKER (Rüdiger); STURM (Volker); KUPSCH (Andreas); KARNER (Elfriede); DEUSCHL (Günther); WITT (Karsten)
AF :	Department of Neurology, Christian-Albrechts-University/Kiel/Allemagne (1 aut., 2 aut., 3 aut., 16 aut., 17 aut.); Department of Neurosurgery, Christian-Albrechts-University/Kiel/Allemagne (4 aut.); Department of Neurology, Heidelberg University/Heidelberg/Allemagne (5 aut., 7 aut.); Department of Neurosurgery, Heidelberg University/Heidelberg/Allemagne (6 aut.); Department of Neurology, Heinrich Heine University/Dusseldorf/Allemagne (8 aut., 9 aut.); Department of Neurology, Ludwig-Maximilians-University/Munich/Allemagne (10 aut., 11 aut.); Department of Neurology, Cologne University/Cologne/Allemagne (12 aut.); Department of Neurosurgery, Cologne University/Cologne/Allemagne (13 aut.); Department of Neurology, Charité Hospital, Humboldt University/Berlin/Allemagne (14 aut.); Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (15 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 11; Pp. 1583-1589; Bibl. 35 ref.
LA :	Anglais
EA :	A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains "global cognitive functioning," "memory," "working memory," "attention," and "executive function." These domain-specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN-DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa-equivalence dosage (LED) and axial subscore of the UPDRS in the off-medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN-DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN-DBS.
CC :	002B17; 002B17G
FD :	Trouble cognitif; Maladie de Parkinson; Pathologie du système nerveux; Facteur risque; Noyau sousthalamique
FG :	Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Cognitive disorder; Parkinson disease; Nervous system diseases; Risk factor; Subthalamic nucleus
EG :	Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Trastorno cognitivo; Parkinson enfermedad; Sistema nervioso patología; Factor riesgo; Núcleo subtalámico
LO :	INIST-20953.354000192608100080
ID :	10-0413277

Links to Exploration step

Pascal:10-0413277

Le document en format XML

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<author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease</title>
<author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<sZ>3 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O." last="Pinsker">Markus O. Pinsker</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurosurgery, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Heidelberg University</s1>
<s2>Heidelberg</s2>
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</author>
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<affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Heidelberg University</s1>
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<s3>DEU</s3>
<sZ>5 aut.</sZ>
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</inist:fA14>
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<author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Heinrich Heine University</s1>
<s2>Dusseldorf</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Heinrich Heine University</s1>
<s2>Dusseldorf</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurology, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurology, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Cologne University</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurosurgery, Cologne University</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Charité Hospital, Humboldt University</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name>
<affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s2>Innsbruck</s2>
<s3>AUT</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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</affiliation>
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<author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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</imprint>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
</seriesStmt>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble cognitif</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
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<front><div type="abstract" xml:lang="en">A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains "global cognitive functioning," "memory," "working memory," "attention," and "executive function." These domain-specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN-DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa-equivalence dosage (LED) and axial subscore of the UPDRS in the off-medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN-DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN-DBS.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease</s1>
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<sZ>17 aut.</sZ>
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<fA14 i1="03"><s1>Department of Neurology, Heidelberg University</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurosurgery, Heidelberg University</s1>
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<fA14 i1="05"><s1>Department of Neurology, Heinrich Heine University</s1>
<s2>Dusseldorf</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<fA14 i1="06"><s1>Department of Neurology, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<sZ>14 aut.</sZ>
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<fA14 i1="10"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s2>Innsbruck</s2>
<s3>AUT</s3>
<sZ>15 aut.</sZ>
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<fA20><s1>1583-1589</s1>
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<fA45><s0>35 ref.</s0>
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<fC02 i1="02" i2="X"><s0>002B17G</s0>
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<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Cognitive disorder</s0>
<s5>01</s5>
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<s5>01</s5>
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<s5>02</s5>
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<s5>02</s5>
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<s2>NM</s2>
<s5>02</s5>
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<s5>03</s5>
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<s5>03</s5>
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<s5>03</s5>
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<s5>09</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Risk factor</s0>
<s5>09</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Factor riesgo</s0>
<s5>09</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>10</s5>
</fC03>
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<s5>10</s5>
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<s5>10</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>38</s5>
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<s5>39</s5>
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<fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>40</s5>
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<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
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<s5>41</s5>
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<s5>41</s5>
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<s5>42</s5>
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<s5>42</s5>
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<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
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<server><NO>PASCAL 10-0413277 INIST</NO>
<ET>Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease</ET>
<AU>DANIELS (Christine); KRACK (Paul); VOLKMANN (Jens); PINSKER (Markus O.); KRAUSE (Martin); TRONNIER (Volker); KLOSS (Manja); SCHNITZLER (Alfons); WOJTECKI (Lars); BÖTZEL (Kai); DANEK (Adrian); HILKER (Rüdiger); STURM (Volker); KUPSCH (Andreas); KARNER (Elfriede); DEUSCHL (Günther); WITT (Karsten)</AU>
<AF>Department of Neurology, Christian-Albrechts-University/Kiel/Allemagne (1 aut., 2 aut., 3 aut., 16 aut., 17 aut.); Department of Neurosurgery, Christian-Albrechts-University/Kiel/Allemagne (4 aut.); Department of Neurology, Heidelberg University/Heidelberg/Allemagne (5 aut., 7 aut.); Department of Neurosurgery, Heidelberg University/Heidelberg/Allemagne (6 aut.); Department of Neurology, Heinrich Heine University/Dusseldorf/Allemagne (8 aut., 9 aut.); Department of Neurology, Ludwig-Maximilians-University/Munich/Allemagne (10 aut., 11 aut.); Department of Neurology, Cologne University/Cologne/Allemagne (12 aut.); Department of Neurosurgery, Cologne University/Cologne/Allemagne (13 aut.); Department of Neurology, Charité Hospital, Humboldt University/Berlin/Allemagne (14 aut.); Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (15 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 11; Pp. 1583-1589; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>A slight decline in cognitive functions and especially in executive functioning after deep brain stimulation (DBS) of the nucleus subthalamicus (STN) in patients with Parkinson's disease (PD) has been described. This study evaluated baseline parameters that contribute to a deterioration of cognitive functioning after DBS. We analyzed data from the neuropsychological protocol in a randomized controlled study comparing DBS with best medical treatment (BMT). Change scores were calculated for the cognitive domains "global cognitive functioning," "memory," "working memory," "attention," and "executive function." These domain-specific change scores were correlated with previously defined preoperative parameters. Compared with the BMT group (63 patients), the STN-DBS group (60 patients) showed a significant decline only in the domain executive function 6 months after DBS, which was significantly correlated with age, levodopa-equivalence dosage (LED) and axial subscore of the UPDRS in the off-medication state at baseline. Multiple regression analysis showed that these three factors explained, however, only about 23% of the variance. Patients with higher age, higher baseline LED, and/or higher axial subscore of the UPDRS at baseline have an increased risk for worsening of executive function after STN-DBS. High scores of these factors might reflect an advanced stage of disease progression. As these baseline factors explained the variance of the change score executive function only to a minor proportion, other factors including the surgical procedure, the exact placement of the electrode or postsurgical management might be more relevant for a decline in executive functioning after STN-DBS.</EA>
<CC>002B17; 002B17G</CC>
<FD>Trouble cognitif; Maladie de Parkinson; Pathologie du   système nerveux; Facteur risque; Noyau sousthalamique</FD>
<FG>Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Cognitive disorder; Parkinson disease; Nervous system diseases; Risk factor; Subthalamic nucleus</ED>
<EG>Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Trastorno cognitivo; Parkinson enfermedad; Sistema nervioso patología; Factor riesgo; Núcleo subtalámico</SD>
<LO>INIST-20953.354000192608100080</LO>
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   |type=    RBID
   |clé=     Pascal:10-0413277
   |texte=   Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease
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	Movement Disorders (revue)
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Movement Disorders (revue)

Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease

Risk Factors for Executive Dysfunction After Subthalamic Nucleus Stimulation in Parkinson's Disease

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