MovDisordV3, PascalFrancis, Corpus, bibRecord, 000880

Blood Oxygenation Level-Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease

Identifieur interne : 000880 ( PascalFrancis/Corpus ); précédent : 000879; suivant : 000881

Blood Oxygenation Level-Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease

Auteurs : Janey Prodoehl ; Mathew Spraker ; Daniel Corcos ; Cynthia Comella ; David Vaillancourt

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0474348

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Oxygénation, Noyau gris central, De novo, Imagerie RMN.

English descriptors

KwdEn :
- Basal ganglion, De novo, Nervous system diseases, Nuclear magnetic resonance imaging, Oxygenation, Parkinson disease.

Abstract

To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity. This study examines the relation between blood oxygenation level-dependent (BOLD) activation in every nucleus of the BG and symptom-specific disease severity in early stage de novo PD. BOLD activation measured at 3 T was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the BG nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified PD Rating Scale and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the BG and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the BG relates most consistently to bradykinesia and functional magnetic resonance imaging has strong potential to serve as a noninvasive marker for the state of BG function in de novo PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 SPRAKER (Mathew)`
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A11	`05`	`1`		`@1 VAILLANCOURT (David)`
A14	`01`			`@1 Department of Kinesiology and Nutrition, University of Illinois at Chicago @2 Chicago, Illinois @3 USA @Z 1 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 Department of Bioengineering, University of Illinois at Chicago @2 Chicago, Illinois @3 USA @Z 2 aut. @Z 3 aut. @Z 5 aut.`
A14	`03`			`@1 Department of Physical Therapy, University of Illinois at Chicago @2 Chicago, Illinois @3 USA @Z 3 aut.`
A14	`04`			`@1 Department of Neurological Sciences, Rush University Medical Center @2 Chicago, Illinois @3 USA @Z 3 aut. @Z 4 aut.`
A14	`05`			`@1 Department of Neurology and Rehabilitation, University of Illinois at Chicago @2 Chicago, Illinois @3 USA @Z 5 aut.`
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C01	`01`		`ENG`	@0 To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity. This study examines the relation between blood oxygenation level-dependent (BOLD) activation in every nucleus of the BG and symptom-specific disease severity in early stage de novo PD. BOLD activation measured at 3 T was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the BG nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified PD Rating Scale and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the BG and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the BG relates most consistently to bradykinesia and functional magnetic resonance imaging has strong potential to serve as a noninvasive marker for the state of BG function in de novo PD.
C02	`01`	`X`		`@0 002B17`
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C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
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C03	`04`	`X`	`FRE`	`@0 Noyau gris central @5 10`
C03	`04`	`X`	`ENG`	`@0 Basal ganglion @5 10`
C03	`04`	`X`	`SPA`	`@0 Núcleo basal @5 10`
C03	`05`	`X`	`FRE`	`@0 De novo @5 11`
C03	`05`	`X`	`ENG`	`@0 De novo @5 11`
C03	`05`	`X`	`SPA`	`@0 De novo @5 11`
C03	`06`	`X`	`FRE`	`@0 Imagerie RMN @5 12`
C03	`06`	`X`	`ENG`	`@0 Nuclear magnetic resonance imaging @5 12`
C03	`06`	`X`	`SPA`	`@0 Imaginería RMN @5 12`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 40`
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C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
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Format Inist (serveur)

NO :	PASCAL 10-0474348 INIST
ET :	Blood Oxygenation Level-Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease
AU :	PRODOEHL (Janey); SPRAKER (Mathew); CORCOS (Daniel); COMELLA (Cynthia); VAILLANCOURT (David)
AF :	Department of Kinesiology and Nutrition, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (1 aut., 3 aut., 5 aut.); Department of Bioengineering, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (2 aut., 3 aut., 5 aut.); Department of Physical Therapy, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (3 aut.); Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (3 aut., 4 aut.); Department of Neurology and Rehabilitation, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 13; Pp. 2035-2043; Bibl. 26 ref.
LA :	Anglais
EA :	To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity. This study examines the relation between blood oxygenation level-dependent (BOLD) activation in every nucleus of the BG and symptom-specific disease severity in early stage de novo PD. BOLD activation measured at 3 T was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the BG nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified PD Rating Scale and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the BG and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the BG relates most consistently to bradykinesia and functional magnetic resonance imaging has strong potential to serve as a noninvasive marker for the state of BG function in de novo PD.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Oxygénation; Noyau gris central; De novo; Imagerie RMN
FG :	Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Oxygenation; Basal ganglion; De novo; Nuclear magnetic resonance imaging
EG :	Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Oxigenación; Núcleo basal; De novo; Imaginería RMN
LO :	INIST-20953.354000193258110050
ID :	10-0474348

Links to Exploration step

Pascal:10-0474348

Le document en format XML

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<front><div type="abstract" xml:lang="en">To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity. This study examines the relation between blood oxygenation level-dependent (BOLD) activation in every nucleus of the BG and symptom-specific disease severity in early stage de novo PD. BOLD activation measured at 3 T was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the BG nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified PD Rating Scale and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the BG and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the BG relates most consistently to bradykinesia and functional magnetic resonance imaging has strong potential to serve as a noninvasive marker for the state of BG function in de novo PD.</div>
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<server><NO>PASCAL 10-0474348 INIST</NO>
<ET>Blood Oxygenation Level-Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease</ET>
<AU>PRODOEHL (Janey); SPRAKER (Mathew); CORCOS (Daniel); COMELLA (Cynthia); VAILLANCOURT (David)</AU>
<AF>Department of Kinesiology and Nutrition, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (1 aut., 3 aut., 5 aut.); Department of Bioengineering, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (2 aut., 3 aut., 5 aut.); Department of Physical Therapy, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (3 aut.); Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (3 aut., 4 aut.); Department of Neurology and Rehabilitation, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 13; Pp. 2035-2043; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity. This study examines the relation between blood oxygenation level-dependent (BOLD) activation in every nucleus of the BG and symptom-specific disease severity in early stage de novo PD. BOLD activation measured at 3 T was compared between 20 early stage de novo PD patients and 20 controls during an established precision grip force task. In addition to the BG nuclei, activation in specific thalamic and cortical regions was examined. There were three novel findings. First, there were significant negative correlations between total motor Unified PD Rating Scale and BOLD activation in bilateral caudate, bilateral putamen, contralateral external segment of the globus pallidus, bilateral subthalamic nucleus, contralateral substantia nigra, and thalamus. Second, bradykinesia was the symptom that most consistently predicted BOLD activation in the BG and thalamus. Also, BOLD activation in the contralateral internal globus pallidus was related to tremor. Third, the reduced cortical activity in primary motor cortex and supplementary motor area in de novo PD did not relate to motor symptoms. These findings demonstrate that BOLD activity in nuclei of the BG relates most consistently to bradykinesia and functional magnetic resonance imaging has strong potential to serve as a noninvasive marker for the state of BG function in de novo PD.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Oxygénation; Noyau gris central; De novo; Imagerie RMN</FD>
<FG>Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Oxygenation; Basal ganglion; De novo; Nuclear magnetic resonance imaging</ED>
<EG>Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Oxigenación; Núcleo basal; De novo; Imaginería RMN</SD>
<LO>INIST-20953.354000193258110050</LO>
<ID>10-0474348</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Blood Oxygenation Level-Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease

Blood Oxygenation Level-Dependent Activation in Basal Ganglia Nuclei Relates to Specific Symptoms in De Novo Parkinson's Disease

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