MovDisordV3, PascalFrancis, Corpus, bibRecord, 000818

Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model

Identifieur interne : 000818 ( PascalFrancis/Corpus ); précédent : 000817; suivant : 000819

Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model

Auteurs : Ann E. Kingsbury ; Rina Bandopadhyay ; Laura Silveira-Moriyama ; Hilary Ayling ; Constantinos Kallis ; William Sterlacci ; Hans Maeir ; Werner Poewe ; Andrew J. Lees

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0512928

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Tronc cérébral, Anatomopathologie, Evaluation, Modèle, Corps Lewy, Bulbe rachidien, Noyau dorsal, Noyau moteur.

English descriptors

KwdEn :
- Anatomic pathology, Brain stem, Dorsal nucleus, Evaluation, Lewy body, Medulla oblongata, Models, Motor nucleus, Nervous system diseases, Parkinson disease.

Abstract

The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically-normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model`
A11	`01`	`1`		`@1 KINGSBURY (Ann E.)`
A11	`02`	`1`		`@1 BANDOPADHYAY (Rina)`
A11	`03`	`1`		`@1 SILVEIRA-MORIYAMA (Laura)`
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A11	`05`	`1`		`@1 KALLIS (Constantinos)`
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A14	`03`			`@1 Department of Pathology, Innsbruck Medical University @2 Innsbruck @3 AUT @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A14	`04`			`@1 Queen Square Brain Bank for Neurological Disorders, UCL, Institute of Neurology @2 London @3 GBR @Z 9 aut.`
A20				`@1 2508-2515`
A21				`@1 2010`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically-normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another.
C02	`01`	`X`		`@0 002B17`
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C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Tronc cérébral @5 09`
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C03	`03`	`X`	`SPA`	`@0 Tronco cerebral @5 09`
C03	`04`	`X`	`FRE`	`@0 Anatomopathologie @5 10`
C03	`04`	`X`	`ENG`	`@0 Anatomic pathology @5 10`
C03	`04`	`X`	`SPA`	`@0 Anatomía patológica @5 10`
C03	`05`	`X`	`FRE`	`@0 Evaluation @5 11`
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C03	`05`	`X`	`SPA`	`@0 Evaluación @5 11`
C03	`06`	`X`	`FRE`	`@0 Modèle @5 12`
C03	`06`	`X`	`ENG`	`@0 Models @5 12`
C03	`06`	`X`	`SPA`	`@0 Modelo @5 12`
C03	`07`	`X`	`FRE`	`@0 Corps Lewy @5 13`
C03	`07`	`X`	`ENG`	`@0 Lewy body @5 13`
C03	`07`	`X`	`SPA`	`@0 Cuerpo Lewy @5 13`
C03	`08`	`X`	`FRE`	`@0 Bulbe rachidien @5 14`
C03	`08`	`X`	`ENG`	`@0 Medulla oblongata @5 14`
C03	`08`	`X`	`SPA`	`@0 Bulbo raquídeo @5 14`
C03	`09`	`X`	`FRE`	`@0 Noyau dorsal @5 15`
C03	`09`	`X`	`ENG`	`@0 Dorsal nucleus @5 15`
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C03	`10`	`X`	`FRE`	`@0 Noyau moteur @5 16`
C03	`10`	`X`	`ENG`	`@0 Motor nucleus @5 16`
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C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
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C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 42`
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N21				`@1 347`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0512928 INIST
ET :	Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model
AU :	KINGSBURY (Ann E.); BANDOPADHYAY (Rina); SILVEIRA-MORIYAMA (Laura); AYLING (Hilary); KALLIS (Constantinos); STERLACCI (William); MAEIR (Hans); POEWE (Werner); LEES (Andrew J.)
AF :	Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology/London/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 9 aut.); Medical Statistics Unit, London School of Hygiene and Tropical Medicine/London/Royaume-Uni (5 aut.); Department of Pathology, Innsbruck Medical University/Innsbruck/Autriche (6 aut., 7 aut., 8 aut.); Queen Square Brain Bank for Neurological Disorders, UCL, Institute of Neurology/London/Royaume-Uni (9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 15; Pp. 2508-2515; Bibl. 31 ref.
LA :	Anglais
EA :	The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically-normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Tronc cérébral; Anatomopathologie; Evaluation; Modèle; Corps Lewy; Bulbe rachidien; Noyau dorsal; Noyau moteur
FG :	Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Brain stem; Anatomic pathology; Evaluation; Models; Lewy body; Medulla oblongata; Dorsal nucleus; Motor nucleus
EG :	Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Tronco cerebral; Anatomía patológica; Evaluación; Modelo; Cuerpo Lewy; Bulbo raquídeo; Núcleo dorsal; Núcleo motor
LO :	INIST-20953.354000191411680050
ID :	10-0512928

Links to Exploration step

Pascal:10-0512928

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term>
<term>Brain stem</term>
<term>Dorsal nucleus</term>
<term>Evaluation</term>
<term>Lewy body</term>
<term>Medulla oblongata</term>
<term>Models</term>
<term>Motor nucleus</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Tronc cérébral</term>
<term>Anatomopathologie</term>
<term>Evaluation</term>
<term>Modèle</term>
<term>Corps Lewy</term>
<term>Bulbe rachidien</term>
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<front><div type="abstract" xml:lang="en">The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically-normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model</s1>
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<fA11 i1="01" i2="1"><s1>KINGSBURY (Ann E.)</s1>
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<fA11 i1="02" i2="1"><s1>BANDOPADHYAY (Rina)</s1>
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<fA11 i1="03" i2="1"><s1>SILVEIRA-MORIYAMA (Laura)</s1>
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<fA11 i1="05" i2="1"><s1>KALLIS (Constantinos)</s1>
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<fA11 i1="07" i2="1"><s1>MAEIR (Hans)</s1>
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<fA11 i1="08" i2="1"><s1>POEWE (Werner)</s1>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>9 aut.</sZ>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="04"><s1>Queen Square Brain Bank for Neurological Disorders, UCL, Institute of Neurology</s1>
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<sZ>9 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically-normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another.</s0>
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<s5>01</s5>
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<s5>01</s5>
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<s5>09</s5>
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<fC03 i1="06" i2="X" l="ENG"><s0>Models</s0>
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<s5>15</s5>
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<s5>16</s5>
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<s5>37</s5>
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<s5>39</s5>
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<s5>39</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
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<s5>40</s5>
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<server><NO>PASCAL 10-0512928 INIST</NO>
<ET>Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model</ET>
<AU>KINGSBURY (Ann E.); BANDOPADHYAY (Rina); SILVEIRA-MORIYAMA (Laura); AYLING (Hilary); KALLIS (Constantinos); STERLACCI (William); MAEIR (Hans); POEWE (Werner); LEES (Andrew J.)</AU>
<AF>Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology/London/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 9 aut.); Medical Statistics Unit, London School of Hygiene and Tropical Medicine/London/Royaume-Uni (5 aut.); Department of Pathology, Innsbruck Medical University/Innsbruck/Autriche (6 aut., 7 aut., 8 aut.); Queen Square Brain Bank for Neurological Disorders, UCL, Institute of Neurology/London/Royaume-Uni (9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 15; Pp. 2508-2515; Bibl. 31 ref.</SO>
<LA>Anglais</LA>
<EA>The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically-normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Tronc cérébral; Anatomopathologie; Evaluation; Modèle; Corps Lewy; Bulbe rachidien; Noyau dorsal; Noyau moteur</FD>
<FG>Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Brain stem; Anatomic pathology; Evaluation; Models; Lewy body; Medulla oblongata; Dorsal nucleus; Motor nucleus</ED>
<EG>Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Tronco cerebral; Anatomía patológica; Evaluación; Modelo; Cuerpo Lewy; Bulbo raquídeo; Núcleo dorsal; Núcleo motor</SD>
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Movement Disorders (revue)

Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model

Brain Stem Pathology in Parkinson's Disease: An Evaluation of the Braak Staging Model

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