MovDisordV3, PascalFrancis, Corpus, bibRecord, 000771

Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson's Disease: In Vivo Imaging with [18F]Fallypride

Identifieur interne : 000771 ( PascalFrancis/Corpus ); précédent : 000770; suivant : 000772

Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson's Disease: In Vivo Imaging with [18F]Fallypride

Auteurs : Marta G. Vuckovic ; QUANZHENG LI ; Beth Fisher ; Angelo Nacca ; Richard M. Leahy ; John P. Walsh ; Jogesh Mukherjee ; Celia Williams ; Michael W. Jakowec ; Giselle M. Petzinger

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:11-0065128

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Exercice physique, Récepteur dopaminergique D2, Modèle animal, Tomoscintigraphie, Tomographie par émission de positons, Noyau gris central, Epreuve tapis roulant.

English descriptors

KwdEn :
- Animal model, Basal ganglion, D2 Dopamine receptor, Emission tomography, Nervous system diseases, Parkinson disease, Physical exercise, Positron emission tomography, Treadmill exercise.

Abstract

The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [¹⁸F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [¹⁸F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`03`			`@1 Viterbi School of Engineering, University of Southern California @2 Los Angeles, California @3 USA @Z 2 aut. @Z 5 aut.`
A14	`04`			`@1 Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California @2 Los Angeles, California @3 USA @Z 3 aut. @Z 9 aut. @Z 10 aut.`
A14	`05`			`@1 Department of Radiology, University of Southern California @2 Los Angeles, California @3 USA @Z 4 aut.`
A14	`06`			`@1 Andrus Gerontology Center, University of Southern California @2 Los Angeles, California @3 USA @Z 6 aut.`
A14	`07`			`@1 Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine @2 Irvine, California @3 USA @Z 7 aut.`
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C01	`01`		`ENG`	@0 The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [¹⁸F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [¹⁸F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.
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C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Exercice physique @5 09`
C03	`03`	`X`	`ENG`	`@0 Physical exercise @5 09`
C03	`03`	`X`	`SPA`	`@0 Ejercicio físico @5 09`
C03	`04`	`X`	`FRE`	`@0 Récepteur dopaminergique D2 @5 10`
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C03	`05`	`X`	`FRE`	`@0 Modèle animal @5 11`
C03	`05`	`X`	`ENG`	`@0 Animal model @5 11`
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C03	`06`	`X`	`SPA`	`@0 Tomocentelleografía @5 12`
C03	`07`	`X`	`FRE`	`@0 Tomographie par émission de positons @5 13`
C03	`07`	`X`	`ENG`	`@0 Positron emission tomography @5 13`
C03	`07`	`X`	`SPA`	`@0 Tomografía emisión positrones @5 13`
C03	`08`	`X`	`FRE`	`@0 Noyau gris central @5 14`
C03	`08`	`X`	`ENG`	`@0 Basal ganglion @5 14`
C03	`08`	`X`	`SPA`	`@0 Núcleo basal @5 14`
C03	`09`	`X`	`FRE`	`@0 Epreuve tapis roulant @5 15`
C03	`09`	`X`	`ENG`	`@0 Treadmill exercise @5 15`
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C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
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C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
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C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Encéphale @5 42`
C07	`05`	`X`	`ENG`	`@0 Encephalon @5 42`
C07	`05`	`X`	`SPA`	`@0 Encéfalo @5 42`
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Format Inist (serveur)

NO :	PASCAL 11-0065128 INIST
ET :	Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson's Disease: In Vivo Imaging with [¹⁸F]Fallypride
AU :	VUCKOVIC (Marta G.); QUANZHENG LI; FISHER (Beth); NACCA (Angelo); LEAHY (Richard M.); WALSH (John P.); MUKHERJEE (Jogesh); WILLIAMS (Celia); JAKOWEC (Michael W.); PETZINGER (Giselle M.)
AF :	Neuroscience Graduate Program, University of Southern California/Los Angeles, California/Etats-Unis (1 aut.); The George and Mary Lou Boone Center for Parkinson's Disease Research, Department of Neurology; University of Southern California/Los Angles, California/Etats-Unis (1 aut., 8 aut., 9 aut., 10 aut.); Viterbi School of Engineering, University of Southern California/Los Angeles, California/Etats-Unis (2 aut., 5 aut.); Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California/Los Angeles, California/Etats-Unis (3 aut., 9 aut., 10 aut.); Department of Radiology, University of Southern California/Los Angeles, California/Etats-Unis (4 aut.); Andrus Gerontology Center, University of Southern California/Los Angeles, California/Etats-Unis (6 aut.); Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine/Irvine, California/Etats-Unis (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 16; Pp. 2777-2784; Bibl. 36 ref.
LA :	Anglais
EA :	The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [¹⁸F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [¹⁸F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Exercice physique; Récepteur dopaminergique D2; Modèle animal; Tomoscintigraphie; Tomographie par émission de positons; Noyau gris central; Epreuve tapis roulant
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central
ED :	Parkinson disease; Nervous system diseases; Physical exercise; D2 Dopamine receptor; Animal model; Emission tomography; Positron emission tomography; Basal ganglion; Treadmill exercise
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system
SD :	Parkinson enfermedad; Sistema nervioso patología; Ejercicio físico; Receptor dopaminérgico D2; Modelo animal; Tomocentelleografía; Tomografía emisión positrones; Núcleo basal; Prueba cinta rodante
LO :	INIST-20953.354000193512620120
ID :	11-0065128

Links to Exploration step

Pascal:11-0065128

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson's Disease: In Vivo Imaging with [<sup>18</sup>
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<author><name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name>
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<author><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name>
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<affiliation><inist:fA14 i1="04"><s1>Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California</s1>
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<series><title level="j" type="main">Movement disorders</title>
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<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Physical exercise</term>
<term>Positron emission tomography</term>
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<term>Tomoscintigraphie</term>
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<front><div type="abstract" xml:lang="en">The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [<sup>18</sup>
F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [<sup>18</sup>
F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.</div>
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F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [<sup>18</sup>
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<ET>Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson's Disease: In Vivo Imaging with [<sup>18</sup>
F]Fallypride</ET>
<AU>VUCKOVIC (Marta G.); QUANZHENG LI; FISHER (Beth); NACCA (Angelo); LEAHY (Richard M.); WALSH (John P.); MUKHERJEE (Jogesh); WILLIAMS (Celia); JAKOWEC (Michael W.); PETZINGER (Giselle M.)</AU>
<AF>Neuroscience Graduate Program, University of Southern California/Los Angeles, California/Etats-Unis (1 aut.); The George and Mary Lou Boone Center for Parkinson's Disease Research, Department of Neurology; University of Southern California/Los Angles, California/Etats-Unis (1 aut., 8 aut., 9 aut., 10 aut.); Viterbi School of Engineering, University of Southern California/Los Angeles, California/Etats-Unis (2 aut., 5 aut.); Philips-Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California/Los Angeles, California/Etats-Unis (3 aut., 9 aut., 10 aut.); Department of Radiology, University of Southern California/Los Angeles, California/Etats-Unis (4 aut.); Andrus Gerontology Center, University of Southern California/Los Angeles, California/Etats-Unis (6 aut.); Preclinical Imaging Center, Department of Psychiatry and Human Behavior, UC Irvine/Irvine, California/Etats-Unis (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 16; Pp. 2777-2784; Bibl. 36 ref.</SO>
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<EA>The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [<sup>18</sup>
F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [<sup>18</sup>
F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.</EA>
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<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Encéphale; Système nerveux central</FG>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson's Disease: In Vivo Imaging with [18F]Fallypride

Exercise Elevates Dopamine D2 Receptor in a Mouse Model of Parkinson's Disease: In Vivo Imaging with [18F]Fallypride

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