Movement Disorders (revue)

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Essential Tremor and Parkinson's Disease: Lack of a Link

Identifieur interne : 000687 ( PascalFrancis/Corpus ); précédent : 000686; suivant : 000688

Essential Tremor and Parkinson's Disease: Lack of a Link

Auteurs : Charles H. Adler ; Holly A. Shill ; Thomas G. Beach

Source :

RBID : Pascal:11-0211279

Descripteurs français

English descriptors

Abstract

Background: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neuro-chemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0885-3185
A03   1    @0 Mov. disord.
A05       @2 26
A06       @2 3
A08 01  1  ENG  @1 Essential Tremor and Parkinson's Disease: Lack of a Link
A11 01  1    @1 ADLER (Charles H.)
A11 02  1    @1 SHILL (Holly A.)
A11 03  1    @1 BEACH (Thomas G.)
A14 01      @1 Parkinson's Disease and Movement Disorders Center, Mayo Clinic @2 Scottsdale, Arizona @3 USA @Z 1 aut.
A14 02      @1 Sun Health Research Institute @2 Sun City, Arizona @3 USA @Z 2 aut. @Z 3 aut.
A20       @1 372-377
A21       @1 2011
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000190875360020
A44       @0 0000 @1 © 2011 INIST-CNRS. All rights reserved.
A45       @0 46 ref.
A47 01  1    @0 11-0211279
A60       @1 P
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 Background: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neuro-chemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed.
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C03 01  X  SPA  @0 Temblor @5 01
C03 02  X  FRE  @0 Maladie de Parkinson @2 NM @5 02
C03 02  X  ENG  @0 Parkinson disease @2 NM @5 02
C03 02  X  SPA  @0 Parkinson enfermedad @2 NM @5 02
C03 03  X  FRE  @0 Pathologie du système nerveux @5 03
C03 03  X  ENG  @0 Nervous system diseases @5 03
C03 03  X  SPA  @0 Sistema nervioso patología @5 03
C03 04  X  FRE  @0 Corps Lewy @5 09
C03 04  X  ENG  @0 Lewy body @5 09
C03 04  X  SPA  @0 Cuerpo Lewy @5 09
C07 01  X  FRE  @0 Mouvement involontaire @5 37
C07 01  X  ENG  @0 Involuntary movement @5 37
C07 01  X  SPA  @0 Movimiento involuntario @5 37
C07 02  X  FRE  @0 Trouble neurologique @5 39
C07 02  X  ENG  @0 Neurological disorder @5 39
C07 02  X  SPA  @0 Trastorno neurológico @5 39
C07 03  X  FRE  @0 Pathologie de l'encéphale @5 40
C07 03  X  ENG  @0 Cerebral disorder @5 40
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C07 04  X  ENG  @0 Extrapyramidal syndrome @5 41
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C07 05  X  FRE  @0 Maladie dégénérative @5 42
C07 05  X  ENG  @0 Degenerative disease @5 42
C07 05  X  SPA  @0 Enfermedad degenerativa @5 42
C07 06  X  FRE  @0 Pathologie du système nerveux central @5 43
C07 06  X  ENG  @0 Central nervous system disease @5 43
C07 06  X  SPA  @0 Sistema nervosio central patología @5 43
N21       @1 143
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 11-0211279 INIST
ET : Essential Tremor and Parkinson's Disease: Lack of a Link
AU : ADLER (Charles H.); SHILL (Holly A.); BEACH (Thomas G.)
AF : Parkinson's Disease and Movement Disorders Center, Mayo Clinic/Scottsdale, Arizona/Etats-Unis (1 aut.); Sun Health Research Institute/Sun City, Arizona/Etats-Unis (2 aut., 3 aut.)
DT : Publication en série; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 3; Pp. 372-377; Bibl. 46 ref.
LA : Anglais
EA : Background: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neuro-chemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed.
CC : 002B17; 002B17G
FD : Tremblement; Maladie de Parkinson; Pathologie du système nerveux; Corps Lewy
FG : Mouvement involontaire; Trouble neurologique; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED : Tremor; Parkinson disease; Nervous system diseases; Lewy body
EG : Involuntary movement; Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD : Temblor; Parkinson enfermedad; Sistema nervioso patología; Cuerpo Lewy
LO : INIST-20953.354000190875360020
ID : 11-0211279

Links to Exploration step

Pascal:11-0211279

Le document en format XML

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   |area=    MovDisordV3
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:11-0211279
   |texte=   Essential Tremor and Parkinson's Disease: Lack of a Link
}}

Wicri

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