MovDisordV3, PascalFrancis, Corpus, bibRecord, 000640

Brain Diffusion-Weighted Imaging in Friedreich's Ataxia

Identifieur interne : 000640 ( PascalFrancis/Corpus ); précédent : 000639; suivant : 000641

Brain Diffusion-Weighted Imaging in Friedreich's Ataxia

Auteurs : Giovanni Rizzo ; Caterina Tonon ; Maria Lucia Valentino ; David Manners ; Filippo Fortuna ; Cinzia Gellera ; Antonella Pini ; Alessandro Ghezzo ; Agostino Baruzzi ; Claudia Testa ; Emil Malucelli ; Bruno Barbiroli ; Valerio Carelli ; Raffaele Lodi

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0228374

Descripteurs français

Pascal (Inist)
- Hérédodégénérescence spinocérébelleuse de Friedreich, Pathologie du système nerveux, Encéphale, Imagerie RMN.

English descriptors

KwdEn :
- Encephalon, Friedreich ataxia, Nervous system diseases, Nuclear magnetic resonance imaging.

Abstract

Background: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion-weighted imaging (DWI). Methods: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion: Our results showed that DWI is a suitable non-invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 11-0228374 INIST
ET :	Brain Diffusion-Weighted Imaging in Friedreich's Ataxia
AU :	RIZZO (Giovanni); TONON (Caterina); LUCIA VALENTINO (Maria); MANNERS (David); FORTUNA (Filippo); GELLERA (Cinzia); PINI (Antonella); GHEZZO (Alessandro); BARUZZI (Agostino); TESTA (Claudia); MALUCELLI (Emil); BARBIROLI (Bruno); CARELLI (Valerio); LODI (Raffaele)
AF :	MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna/Bologna/Italie (1 aut., 2 aut., 4 aut., 5 aut., 10 aut., 11 aut., 12 aut., 14 aut.); Department of Neurological Sciences, University of Bologna/Bologna/Italie (1 aut., 3 aut., 5 aut., 9 aut., 13 aut.); U.O. Biochemistry and Genetics, Fondazione IRCCS-Istituto Neurologico Nazionale "Carlo Besta"/Milano/Italie (6 aut.); Neuropsichiatric Unit, Ospedale Maggiore/Bologna/Italie (7 aut., 8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 4; Pp. 705-712; Bibl. 35 ref.
LA :	Anglais
EA :	Background: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion-weighted imaging (DWI). Methods: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion: Our results showed that DWI is a suitable non-invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP.
CC :	002B17; 002B24A06
FD :	Hérédodégénérescence spinocérébelleuse de Friedreich; Pathologie du système nerveux; Encéphale; Imagerie RMN
FG :	Système nerveux central; Pathologie de l'encéphale; Maladie dégénérative; Maladie héréditaire; Pathologie de la moelle épinière; Pathologie du système nerveux central
ED :	Friedreich ataxia; Nervous system diseases; Encephalon; Nuclear magnetic resonance imaging
EG :	Central nervous system; Cerebral disorder; Degenerative disease; Genetic disease; Spinal cord disease; Central nervous system disease
SD :	Heredodegeneración espinocerebelosa Friedreich; Sistema nervioso patología; Encéfalo; Imaginería RMN
LO :	INIST-20953.354000189767540200
ID :	11-0228374

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Pascal:11-0228374

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Brain Diffusion-Weighted Imaging in Friedreich's Ataxia</title>
<author><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name>
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<author><name sortKey="Lucia Valentino, Maria" sort="Lucia Valentino, Maria" uniqKey="Lucia Valentino M" first="Maria" last="Lucia Valentino">Maria Lucia Valentino</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurological Sciences, University of Bologna</s1>
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<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
<affiliation><inist:fA14 i1="01"><s1>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna</s1>
<s2>Bologna</s2>
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<affiliation><inist:fA14 i1="01"><s1>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna</s1>
<s2>Bologna</s2>
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<affiliation><inist:fA14 i1="02"><s1>Department of Neurological Sciences, University of Bologna</s1>
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<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<author><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name>
<affiliation><inist:fA14 i1="03"><s1>U.O. Biochemistry and Genetics, Fondazione IRCCS-Istituto Neurologico Nazionale "Carlo Besta"</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
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<author><name sortKey="Pini, Antonella" sort="Pini, Antonella" uniqKey="Pini A" first="Antonella" last="Pini">Antonella Pini</name>
<affiliation><inist:fA14 i1="04"><s1>Neuropsichiatric Unit, Ospedale Maggiore</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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</author>
<author><name sortKey="Ghezzo, Alessandro" sort="Ghezzo, Alessandro" uniqKey="Ghezzo A" first="Alessandro" last="Ghezzo">Alessandro Ghezzo</name>
<affiliation><inist:fA14 i1="04"><s1>Neuropsichiatric Unit, Ospedale Maggiore</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name>
<affiliation><inist:fA14 i1="01"><s1>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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<author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name>
<affiliation><inist:fA14 i1="01"><s1>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
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</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
<affiliation><inist:fA14 i1="01"><s1>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
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<author><name sortKey="Carelli, Valerio" sort="Carelli, Valerio" uniqKey="Carelli V" first="Valerio" last="Carelli">Valerio Carelli</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
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</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
<affiliation><inist:fA14 i1="01"><s1>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2011">2011</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Encephalon</term>
<term>Friedreich ataxia</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hérédodégénérescence spinocérébelleuse de Friedreich</term>
<term>Pathologie du   système nerveux</term>
<term>Encéphale</term>
<term>Imagerie RMN</term>
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<front><div type="abstract" xml:lang="en">Background: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion-weighted imaging (DWI). Methods: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion: Our results showed that DWI is a suitable non-invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP.</div>
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<sZ>6 aut.</sZ>
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<server><NO>PASCAL 11-0228374 INIST</NO>
<ET>Brain Diffusion-Weighted Imaging in Friedreich's Ataxia</ET>
<AU>RIZZO (Giovanni); TONON (Caterina); LUCIA VALENTINO (Maria); MANNERS (David); FORTUNA (Filippo); GELLERA (Cinzia); PINI (Antonella); GHEZZO (Alessandro); BARUZZI (Agostino); TESTA (Claudia); MALUCELLI (Emil); BARBIROLI (Bruno); CARELLI (Valerio); LODI (Raffaele)</AU>
<AF>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna/Bologna/Italie (1 aut., 2 aut., 4 aut., 5 aut., 10 aut., 11 aut., 12 aut., 14 aut.); Department of Neurological Sciences, University of Bologna/Bologna/Italie (1 aut., 3 aut., 5 aut., 9 aut., 13 aut.); U.O. Biochemistry and Genetics, Fondazione IRCCS-Istituto Neurologico Nazionale "Carlo Besta"/Milano/Italie (6 aut.); Neuropsichiatric Unit, Ospedale Maggiore/Bologna/Italie (7 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 4; Pp. 705-712; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion-weighted imaging (DWI). Methods: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion: Our results showed that DWI is a suitable non-invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP.</EA>
<CC>002B17; 002B24A06</CC>
<FD>Hérédodégénérescence spinocérébelleuse de Friedreich; Pathologie du système nerveux; Encéphale; Imagerie RMN</FD>
<FG>Système nerveux central; Pathologie de l'encéphale; Maladie dégénérative; Maladie héréditaire; Pathologie de la moelle épinière; Pathologie du   système nerveux central</FG>
<ED>Friedreich ataxia; Nervous system diseases; Encephalon; Nuclear magnetic resonance imaging</ED>
<EG>Central nervous system; Cerebral disorder; Degenerative disease; Genetic disease; Spinal cord disease; Central nervous system disease</EG>
<SD>Heredodegeneración espinocerebelosa Friedreich; Sistema nervioso patología; Encéfalo; Imaginería RMN</SD>
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   |texte=   Brain Diffusion-Weighted Imaging in Friedreich's Ataxia
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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain Diffusion-Weighted Imaging in Friedreich's Ataxia

Brain Diffusion-Weighted Imaging in Friedreich's Ataxia

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