MovDisordV3, PascalFrancis, Corpus, bibRecord, 000632

Somatosensory Temporal Discrimination Tested in Patients Receiving Botulinum Toxin Injection for Cervical Dystonia

Identifieur interne : 000632 ( PascalFrancis/Corpus ); précédent : 000631; suivant : 000633

Somatosensory Temporal Discrimination Tested in Patients Receiving Botulinum Toxin Injection for Cervical Dystonia

Auteurs : Alessandra Scontrini ; Antonella Conte ; Giovanni Fabbrini ; Carlo Colosimo ; Flavio Di Stasio ; Gina Ferrazzano ; Alfredo Berardelli

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0228398

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Discrimination, Homme, Bontoxilysin.

English descriptors

KwdEn :
- Bontoxilysin, Discrimination, Dystonia, Human, Nervous system diseases.

Abstract

We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
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A08	`01`	`1`	`ENG`	`@1 Somatosensory Temporal Discrimination Tested in Patients Receiving Botulinum Toxin Injection for Cervical Dystonia`
A11	`01`	`1`		`@1 SCONTRINI (Alessandra)`
A11	`02`	`1`		`@1 CONTE (Antonella)`
A11	`03`	`1`		`@1 FABBRINI (Giovanni)`
A11	`04`	`1`		`@1 COLOSIMO (Carlo)`
A11	`05`	`1`		`@1 DI STASIO (Flavio)`
A11	`06`	`1`		`@1 FERRAZZANO (Gina)`
A11	`07`	`1`		`@1 BERARDELLI (Alfredo)`
A14	`01`			`@1 Department of Neurology and Psychiatry, "Sapienza, " University of Rome @2 Rome @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut.`
A14	`02`			`@1 Department of Neurological Sciences and Neuromed Institute, "Sapienza, " University of Rome @2 Rome @3 ITA @Z 2 aut. @Z 3 aut. @Z 7 aut.`
A20				`@1 742-746`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000189767540280`
A44				`@0 0000 @1 © 2011 INIST-CNRS. All rights reserved.`
A45				`@0 21 ref.`
A47	`01`	`1`		`@0 11-0228398`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17H`
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C03	`01`	`X`	`ENG`	`@0 Dystonia @5 01`
C03	`01`	`X`	`SPA`	`@0 Distonía @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Discrimination @5 09`
C03	`03`	`X`	`ENG`	`@0 Discrimination @5 09`
C03	`03`	`X`	`SPA`	`@0 Discriminación @5 09`
C03	`04`	`X`	`FRE`	`@0 Homme @5 10`
C03	`04`	`X`	`ENG`	`@0 Human @5 10`
C03	`04`	`X`	`SPA`	`@0 Hombre @5 10`
C03	`05`	`X`	`FRE`	`@0 Bontoxilysin @2 FE @2 FR @5 11`
C03	`05`	`X`	`ENG`	`@0 Bontoxilysin @2 FE @2 FR @5 11`
C03	`05`	`X`	`SPA`	`@0 Bontoxilysin @2 FE @2 FR @5 11`
C07	`01`	`X`	`FRE`	`@0 Metalloendopeptidases @2 FE`
C07	`01`	`X`	`ENG`	`@0 Metalloendopeptidases @2 FE`
C07	`01`	`X`	`SPA`	`@0 Metalloendopeptidases @2 FE`
C07	`02`	`X`	`FRE`	`@0 Peptidases @2 FE`
C07	`02`	`X`	`ENG`	`@0 Peptidases @2 FE`
C07	`02`	`X`	`SPA`	`@0 Peptidases @2 FE`
C07	`03`	`X`	`FRE`	`@0 Hydrolases @2 FE`
C07	`03`	`X`	`ENG`	`@0 Hydrolases @2 FE`
C07	`03`	`X`	`SPA`	`@0 Hydrolases @2 FE`
C07	`04`	`X`	`FRE`	`@0 Enzyme @2 FE`
C07	`04`	`X`	`ENG`	`@0 Enzyme @2 FE`
C07	`04`	`X`	`SPA`	`@0 Enzima @2 FE`
C07	`05`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 37`
C07	`05`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 37`
C07	`05`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 37`
C07	`06`	`X`	`FRE`	`@0 Mouvement involontaire @5 38`
C07	`06`	`X`	`ENG`	`@0 Involuntary movement @5 38`
C07	`06`	`X`	`SPA`	`@0 Movimiento involuntario @5 38`
C07	`07`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 39`
C07	`07`	`X`	`ENG`	`@0 Striated muscle disease @5 39`
C07	`07`	`X`	`SPA`	`@0 Músculo estriado patología @5 39`
C07	`08`	`X`	`FRE`	`@0 Trouble neurologique @5 41`
C07	`08`	`X`	`ENG`	`@0 Neurological disorder @5 41`
C07	`08`	`X`	`SPA`	`@0 Trastorno neurológico @5 41`
C07	`09`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 42`
C07	`09`	`X`	`ENG`	`@0 Cerebral disorder @5 42`
C07	`09`	`X`	`SPA`	`@0 Encéfalo patología @5 42`
C07	`10`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 43`
C07	`10`	`X`	`ENG`	`@0 Central nervous system disease @5 43`
C07	`10`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 43`
N21				`@1 150`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 11-0228398 INIST
ET :	Somatosensory Temporal Discrimination Tested in Patients Receiving Botulinum Toxin Injection for Cervical Dystonia
AU :	SCONTRINI (Alessandra); CONTE (Antonella); FABBRINI (Giovanni); COLOSIMO (Carlo); DI STASIO (Flavio); FERRAZZANO (Gina); BERARDELLI (Alfredo)
AF :	Department of Neurology and Psychiatry, "Sapienza, " University of Rome/Rome/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); Department of Neurological Sciences and Neuromed Institute, "Sapienza, " University of Rome/Rome/Italie (2 aut., 3 aut., 7 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 4; Pp. 742-746; Bibl. 21 ref.
LA :	Anglais
EA :	We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation.
CC :	002B17; 002B17H
FD :	Dystonie; Pathologie du système nerveux; Discrimination; Homme; Bontoxilysin
FG :	Metalloendopeptidases; Peptidases; Hydrolases; Enzyme; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du système nerveux central
ED :	Dystonia; Nervous system diseases; Discrimination; Human; Bontoxilysin
EG :	Metalloendopeptidases; Peptidases; Hydrolases; Enzyme; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease
SD :	Distonía; Sistema nervioso patología; Discriminación; Hombre; Bontoxilysin
LO :	INIST-20953.354000189767540280
ID :	11-0228398

Links to Exploration step

Pascal:11-0228398

Le document en format XML

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<front><div type="abstract" xml:lang="en">We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation.</div>
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<fC01 i1="01" l="ENG"><s0>We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation.</s0>
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<fC02 i1="02" i2="X"><s0>002B17H</s0>
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<s5>01</s5>
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<s5>01</s5>
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<s5>10</s5>
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<s2>FR</s2>
<s5>11</s5>
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<fC03 i1="05" i2="X" l="ENG"><s0>Bontoxilysin</s0>
<s2>FE</s2>
<s2>FR</s2>
<s5>11</s5>
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<fC03 i1="05" i2="X" l="SPA"><s0>Bontoxilysin</s0>
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<ET>Somatosensory Temporal Discrimination Tested in Patients Receiving Botulinum Toxin Injection for Cervical Dystonia</ET>
<AU>SCONTRINI (Alessandra); CONTE (Antonella); FABBRINI (Giovanni); COLOSIMO (Carlo); DI STASIO (Flavio); FERRAZZANO (Gina); BERARDELLI (Alfredo)</AU>
<AF>Department of Neurology and Psychiatry, "Sapienza, " University of Rome/Rome/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); Department of Neurological Sciences and Neuromed Institute, "Sapienza, " University of Rome/Rome/Italie (2 aut., 3 aut., 7 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 4; Pp. 742-746; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation.</EA>
<CC>002B17; 002B17H</CC>
<FD>Dystonie; Pathologie du   système nerveux; Discrimination; Homme; Bontoxilysin</FD>
<FG>Metalloendopeptidases; Peptidases; Hydrolases; Enzyme; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du   système nerveux central</FG>
<ED>Dystonia; Nervous system diseases; Discrimination; Human; Bontoxilysin</ED>
<EG>Metalloendopeptidases; Peptidases; Hydrolases; Enzyme; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease</EG>
<SD>Distonía; Sistema nervioso patología; Discriminación; Hombre; Bontoxilysin</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Somatosensory Temporal Discrimination Tested in Patients Receiving Botulinum Toxin Injection for Cervical Dystonia

Somatosensory Temporal Discrimination Tested in Patients Receiving Botulinum Toxin Injection for Cervical Dystonia

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