Depression Comorbidity in Spinocerebellar Ataxia
Identifieur interne : 000602 ( PascalFrancis/Corpus ); précédent : 000601; suivant : 000603Depression Comorbidity in Spinocerebellar Ataxia
Auteurs : Tanja Schmitz-Hübsch ; Mathieu Coudert ; Sophie Tezenas Du Montcel ; Paola Giunti ; Robyn Labrum ; Alexandra Durr ; Pascale Ribai ; Perrine Charles ; Christoph Linnemann ; Ludger Schöls ; Maryla Rakowicz ; Rafal Rola ; Elszbieta Zdzienicka ; Roberto Fancellu ; Caterina Mariotti ; Lazlo Baliko ; Bela Melegh ; Alessandro Filla ; Elena Salvatore ; Bart P. C. Van De Warrenburg ; Sandra Szymanski ; Jon Infante ; Dagmar Timmann ; Sylvia Boesch ; Chantal Depondt ; Jun-Suk Kang ; Jörg B. Schulz ; Thomas Klopstock ; Nicole Lossnitzer ; Bernd Löwe ; Caroline Frick ; Daniela Rottl Nder ; Thomas E. Schlaepfer ; Thomas KlockgetherSource :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.
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Format Inist (serveur)
| NO : | PASCAL 11-0228445 INIST |
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| ET : | Depression Comorbidity in Spinocerebellar Ataxia |
| AU : | SCHMITZ-HÜBSCH (Tanja); COUDERT (Mathieu); TEZENAS DU MONTCEL (Sophie); GIUNTI (Paola); LABRUM (Robyn); DURR (Alexandra); RIBAI (Pascale); CHARLES (Perrine); LINNEMANN (Christoph); SCHÖLS (Ludger); RAKOWICZ (Maryla); ROLA (Rafal); ZDZIENICKA (Elszbieta); FANCELLU (Roberto); MARIOTTI (Caterina); BALIKO (Lazlo); MELEGH (Bela); FILLA (Alessandro); SALVATORE (Elena); VAN DE WARRENBURG (Bart P. C.); SZYMANSKI (Sandra); INFANTE (Jon); TIMMANN (Dagmar); BOESCH (Sylvia); DEPONDT (Chantal); KANG (Jun-Suk); SCHULZ (Jörg B.); KLOPSTOCK (Thomas); LOSSNITZER (Nicole); LÖWE (Bernd); FRICK (Caroline); ROTTLÄNDER (Daniela); SCHLAEPFER (Thomas E.); KLOCKGETHER (Thomas) |
| AF : | Department of Neurology, University Hospital of Bonn/Bonn/Allemagne (1 aut., 34 aut.); Department of Biostatistics and Medical Informatics, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux/Paris/France (2 aut., 3 aut.); Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie/Paris/France (2 aut., 3 aut.); Department of Molecular Neuroscience, Institute of Neurology, Queen Square/London/Royaume-Uni (4 aut.); Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square/London/Royaume-Uni (5 aut.); INSERM, UMR_S679 Neurologie & Thérapeutique Expérimental/Paris/France (6 aut., 7 aut., 8 aut.); AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics/Paris/France (6 aut., 7 aut., 8 aut.); Department of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (9 aut., 10 aut.); Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology/Warsaw/Pologne (11 aut.); First Department of Neurology, Institute of Psychiatry and Neurology/Warsaw/Pologne (12 aut.); Department of Genetics, Institute of Psychiatry and Neurology/Warsaw/Pologne (13 aut.); Department of Biochemistry and Genetics, Fondazione-IRCCS, Istituto Neurologico Carlo Besta/Milan/Italie (14 aut., 15 aut.); Department of Neurology and Stroke, County Hospital/Veszprém/Hongrie (16 aut.); Department of Medical Genetics and Child Development, University of Pecs/Hongrie (17 aut.); Department of Neurology, University of Naples/Naples/Italie (18 aut., 19 aut.); Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center/Nijmegen/Pays-Bas (20 aut.); Department of Neurology, St. Josef Hospital, University Hospital of Bochum/Bochum/Allemagne (21 aut.); Department of Neurology, University Hospital "Marqués de Valdecilla," CIBERNED/Santander/Espagne (22 aut.); Department of Neurology, University Hospital of Essen/Essen/Allemagne (23 aut.); Department of Neurology, University of Innsbruck/Innsbruck/Autriche (24 aut.); Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles/Brussels/Belgique (25 aut.); Department of Neurology, University of Frankfurt/Frankfurt/M/Allemagne (26 aut.); Department of Neurology, University Clinic, RTHW Aachen/Aachen/Allemagne (27 aut.); Department of Neurology, Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University/DEU/Allemagne (28 aut.); Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg/Heidelberg/Allemagne (29 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 5; Pp. 870-876; Bibl. 41 ref. |
| LA : | Anglais |
| EA : | This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. |
| CC : | 002B17; 002B17G |
| FD : | Etat dépressif; Pathologie du système nerveux; Ataxie spinocérébelleuse; Cervelet; Prévalence |
| FG : | Trouble de l'humeur; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central; Encéphale; Système nerveux central |
| ED : | Depression; Nervous system diseases; Spinocerebellar ataxia; Cerebellum; Prevalence |
| EG : | Mood disorder; Degenerative disease; Genetic disease; Central nervous system disease; Encephalon; Central nervous system |
| SD : | Estado depresivo; Sistema nervioso patología; Ataxia spinocerebelosa; Cerebelo; Prevalencia |
| LO : | INIST-20953.354000189767620160 |
| ID : | 11-0228445 |
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Pascal:11-0228445Le document en format XML
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aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Linnemann, Christoph" sort="Linnemann, Christoph" uniqKey="Linnemann C" first="Christoph" last="Linnemann">Christoph Linnemann</name><affiliation><inist:fA14 i1="08"><s1>Department of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation><inist:fA14 i1="08"><s1>Department of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation><inist:fA14 i1="09"><s1>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation><inist:fA14 i1="10"><s1>First Department of Neurology, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zdzienicka, Elszbieta" sort="Zdzienicka, Elszbieta" uniqKey="Zdzienicka E" first="Elszbieta" last="Zdzienicka">Elszbieta Zdzienicka</name><affiliation><inist:fA14 i1="11"><s1>Department of Genetics, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fancellu, Roberto" sort="Fancellu, Roberto" uniqKey="Fancellu R" first="Roberto" last="Fancellu">Roberto Fancellu</name><affiliation><inist:fA14 i1="12"><s1>Department of Biochemistry and Genetics, Fondazione-IRCCS, Istituto Neurologico Carlo Besta</s1><s2>Milan</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation><inist:fA14 i1="12"><s1>Department of Biochemistry and Genetics, Fondazione-IRCCS, Istituto Neurologico Carlo Besta</s1><s2>Milan</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Baliko, Lazlo" sort="Baliko, Lazlo" uniqKey="Baliko L" first="Lazlo" last="Baliko">Lazlo Baliko</name><affiliation><inist:fA14 i1="13"><s1>Department of Neurology and Stroke, County Hospital</s1><s2>Veszprém</s2><s3>HUN</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation><inist:fA14 i1="14"><s1>Department of Medical Genetics and Child Development, University of Pecs</s1><s3>HUN</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation><inist:fA14 i1="15"><s1>Department of Neurology, University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation><inist:fA14 i1="15"><s1>Department of Neurology, University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation><inist:fA14 i1="16"><s1>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation><inist:fA14 i1="17"><s1>Department of Neurology, St. Josef Hospital, University Hospital of Bochum</s1><s2>Bochum</s2><s3>DEU</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name><affiliation><inist:fA14 i1="18"><s1>Department of Neurology, University Hospital "Marqués de Valdecilla," CIBERNED</s1><s2>Santander</s2><s3>ESP</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation><inist:fA14 i1="19"><s1>Department of Neurology, University Hospital of Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation><inist:fA14 i1="20"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name><affiliation><inist:fA14 i1="21"><s1>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles</s1><s2>Brussels</s2><s3>BEL</s3><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kang, Jun Suk" sort="Kang, Jun Suk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation><inist:fA14 i1="22"><s1>Department of Neurology, University of Frankfurt</s1><s2>Frankfurt/M</s2><s3>DEU</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><affiliation><inist:fA14 i1="23"><s1>Department of Neurology, University Clinic, RTHW Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><affiliation><inist:fA14 i1="24"><s1>Department of Neurology, Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University</s1><s2>DEU</s2><s3>DEU</s3><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lossnitzer, Nicole" sort="Lossnitzer, Nicole" uniqKey="Lossnitzer N" first="Nicole" last="Lossnitzer">Nicole Lossnitzer</name><affiliation><inist:fA14 i1="25"><s1>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lowe, Bernd" sort="Lowe, Bernd" uniqKey="Lowe B" first="Bernd" last="Löwe">Bernd Löwe</name></author><author><name sortKey="Frick, Caroline" sort="Frick, Caroline" uniqKey="Frick C" first="Caroline" last="Frick">Caroline Frick</name></author><author><name sortKey="Rottl Nder, Daniela" sort="Rottl Nder, Daniela" uniqKey="Rottl Nder D" first="Daniela" last="Rottl Nder">Daniela Rottl Nder</name></author><author><name sortKey="Schlaepfer, Thomas E" sort="Schlaepfer, Thomas E" uniqKey="Schlaepfer T" first="Thomas E." last="Schlaepfer">Thomas E. Schlaepfer</name></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0228445</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0228445 INIST</idno><idno type="RBID">Pascal:11-0228445</idno><idno type="wicri:Area/PascalFrancis/Corpus">000602</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Depression Comorbidity in Spinocerebellar Ataxia</title><author><name sortKey="Schmitz Hubsch, Tanja" sort="Schmitz Hubsch, Tanja" uniqKey="Schmitz Hubsch T" first="Tanja" last="Schmitz-Hübsch">Tanja Schmitz-Hübsch</name><affiliation><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Coudert, Mathieu" sort="Coudert, Mathieu" uniqKey="Coudert M" first="Mathieu" last="Coudert">Mathieu Coudert</name><affiliation><inist:fA14 i1="02"><s1>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tezenas Du Montcel, Sophie" sort="Tezenas Du Montcel, Sophie" uniqKey="Tezenas Du Montcel S" first="Sophie" last="Tezenas Du Montcel">Sophie Tezenas Du Montcel</name><affiliation><inist:fA14 i1="02"><s1>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name><affiliation><inist:fA14 i1="04"><s1>Department of Molecular Neuroscience, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Labrum, Robyn" sort="Labrum, Robyn" uniqKey="Labrum R" first="Robyn" last="Labrum">Robyn Labrum</name><affiliation><inist:fA14 i1="05"><s1>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name><affiliation><inist:fA14 i1="06"><s1>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimental</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ribai, Pascale" sort="Ribai, Pascale" uniqKey="Ribai P" first="Pascale" last="Ribai">Pascale Ribai</name><affiliation><inist:fA14 i1="06"><s1>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimental</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Charles, Perrine" sort="Charles, Perrine" uniqKey="Charles P" first="Perrine" last="Charles">Perrine Charles</name><affiliation><inist:fA14 i1="06"><s1>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimental</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Linnemann, Christoph" sort="Linnemann, Christoph" uniqKey="Linnemann C" first="Christoph" last="Linnemann">Christoph Linnemann</name><affiliation><inist:fA14 i1="08"><s1>Department of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation><inist:fA14 i1="08"><s1>Department of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation><inist:fA14 i1="09"><s1>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation><inist:fA14 i1="10"><s1>First Department of Neurology, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zdzienicka, Elszbieta" sort="Zdzienicka, Elszbieta" uniqKey="Zdzienicka E" first="Elszbieta" last="Zdzienicka">Elszbieta Zdzienicka</name><affiliation><inist:fA14 i1="11"><s1>Department of Genetics, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fancellu, Roberto" sort="Fancellu, Roberto" uniqKey="Fancellu R" first="Roberto" last="Fancellu">Roberto Fancellu</name><affiliation><inist:fA14 i1="12"><s1>Department of Biochemistry and Genetics, Fondazione-IRCCS, Istituto Neurologico Carlo Besta</s1><s2>Milan</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation><inist:fA14 i1="12"><s1>Department of Biochemistry and Genetics, Fondazione-IRCCS, Istituto Neurologico Carlo Besta</s1><s2>Milan</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Baliko, Lazlo" sort="Baliko, Lazlo" uniqKey="Baliko L" first="Lazlo" last="Baliko">Lazlo Baliko</name><affiliation><inist:fA14 i1="13"><s1>Department of Neurology and Stroke, County Hospital</s1><s2>Veszprém</s2><s3>HUN</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation><inist:fA14 i1="14"><s1>Department of Medical Genetics and Child Development, University of Pecs</s1><s3>HUN</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation><inist:fA14 i1="15"><s1>Department of Neurology, University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation><inist:fA14 i1="15"><s1>Department of Neurology, University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation><inist:fA14 i1="16"><s1>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation><inist:fA14 i1="17"><s1>Department of Neurology, St. Josef Hospital, University Hospital of Bochum</s1><s2>Bochum</s2><s3>DEU</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name><affiliation><inist:fA14 i1="18"><s1>Department of Neurology, University Hospital "Marqués de Valdecilla," CIBERNED</s1><s2>Santander</s2><s3>ESP</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation><inist:fA14 i1="19"><s1>Department of Neurology, University Hospital of Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation><inist:fA14 i1="20"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name><affiliation><inist:fA14 i1="21"><s1>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles</s1><s2>Brussels</s2><s3>BEL</s3><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kang, Jun Suk" sort="Kang, Jun Suk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation><inist:fA14 i1="22"><s1>Department of Neurology, University of Frankfurt</s1><s2>Frankfurt/M</s2><s3>DEU</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><affiliation><inist:fA14 i1="23"><s1>Department of Neurology, University Clinic, RTHW Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><affiliation><inist:fA14 i1="24"><s1>Department of Neurology, Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University</s1><s2>DEU</s2><s3>DEU</s3><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lossnitzer, Nicole" sort="Lossnitzer, Nicole" uniqKey="Lossnitzer N" first="Nicole" last="Lossnitzer">Nicole Lossnitzer</name><affiliation><inist:fA14 i1="25"><s1>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lowe, Bernd" sort="Lowe, Bernd" uniqKey="Lowe B" first="Bernd" last="Löwe">Bernd Löwe</name></author><author><name sortKey="Frick, Caroline" sort="Frick, Caroline" uniqKey="Frick C" first="Caroline" last="Frick">Caroline Frick</name></author><author><name sortKey="Rottl Nder, Daniela" sort="Rottl Nder, Daniela" uniqKey="Rottl Nder D" first="Daniela" last="Rottl Nder">Daniela Rottl Nder</name></author><author><name sortKey="Schlaepfer, Thomas E" sort="Schlaepfer, Thomas E" uniqKey="Schlaepfer T" first="Thomas E." last="Schlaepfer">Thomas E. Schlaepfer</name></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellum</term><term>Depression</term><term>Nervous system diseases</term><term>Prevalence</term><term>Spinocerebellar ataxia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term><term>Pathologie du système nerveux</term><term>Ataxie spinocérébelleuse</term><term>Cervelet</term><term>Prévalence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Depression Comorbidity in Spinocerebellar Ataxia</s1></fA08><fA11 i1="01" i2="1"><s1>SCHMITZ-HÜBSCH (Tanja)</s1></fA11><fA11 i1="02" i2="1"><s1>COUDERT (Mathieu)</s1></fA11><fA11 i1="03" i2="1"><s1>TEZENAS DU MONTCEL (Sophie)</s1></fA11><fA11 i1="04" i2="1"><s1>GIUNTI (Paola)</s1></fA11><fA11 i1="05" i2="1"><s1>LABRUM (Robyn)</s1></fA11><fA11 i1="06" i2="1"><s1>DURR (Alexandra)</s1></fA11><fA11 i1="07" i2="1"><s1>RIBAI (Pascale)</s1></fA11><fA11 i1="08" i2="1"><s1>CHARLES (Perrine)</s1></fA11><fA11 i1="09" i2="1"><s1>LINNEMANN (Christoph)</s1></fA11><fA11 i1="10" i2="1"><s1>SCHÖLS (Ludger)</s1></fA11><fA11 i1="11" i2="1"><s1>RAKOWICZ (Maryla)</s1></fA11><fA11 i1="12" i2="1"><s1>ROLA (Rafal)</s1></fA11><fA11 i1="13" i2="1"><s1>ZDZIENICKA (Elszbieta)</s1></fA11><fA11 i1="14" i2="1"><s1>FANCELLU (Roberto)</s1></fA11><fA11 i1="15" i2="1"><s1>MARIOTTI (Caterina)</s1></fA11><fA11 i1="16" i2="1"><s1>BALIKO (Lazlo)</s1></fA11><fA11 i1="17" i2="1"><s1>MELEGH (Bela)</s1></fA11><fA11 i1="18" i2="1"><s1>FILLA (Alessandro)</s1></fA11><fA11 i1="19" i2="1"><s1>SALVATORE (Elena)</s1></fA11><fA11 i1="20" i2="1"><s1>VAN DE WARRENBURG (Bart P. C.)</s1></fA11><fA11 i1="21" i2="1"><s1>SZYMANSKI (Sandra)</s1></fA11><fA11 i1="22" i2="1"><s1>INFANTE (Jon)</s1></fA11><fA11 i1="23" i2="1"><s1>TIMMANN (Dagmar)</s1></fA11><fA11 i1="24" i2="1"><s1>BOESCH (Sylvia)</s1></fA11><fA11 i1="25" i2="1"><s1>DEPONDT (Chantal)</s1></fA11><fA11 i1="26" i2="1"><s1>KANG (Jun-Suk)</s1></fA11><fA11 i1="27" i2="1"><s1>SCHULZ (Jörg B.)</s1></fA11><fA11 i1="28" i2="1"><s1>KLOPSTOCK (Thomas)</s1></fA11><fA11 i1="29" i2="1"><s1>LOSSNITZER (Nicole)</s1></fA11><fA11 i1="30" i2="1"><s1>LÖWE (Bernd)</s1></fA11><fA11 i1="31" i2="1"><s1>FRICK (Caroline)</s1></fA11><fA11 i1="32" i2="1"><s1>ROTTLÄNDER (Daniela)</s1></fA11><fA11 i1="33" i2="1"><s1>SCHLAEPFER (Thomas E.)</s1></fA11><fA11 i1="34" i2="1"><s1>KLOCKGETHER (Thomas)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, University Hospital of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>34 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Molecular Neuroscience, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimental</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="07"><s1>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>11 aut.</sZ></fA14><fA14 i1="10"><s1>First Department of Neurology, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>12 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Genetics, Institute of Psychiatry and Neurology</s1><s2>Warsaw</s2><s3>POL</s3><sZ>13 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Biochemistry and Genetics, Fondazione-IRCCS, Istituto Neurologico Carlo Besta</s1><s2>Milan</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Neurology and Stroke, County Hospital</s1><s2>Veszprém</s2><s3>HUN</s3><sZ>16 aut.</sZ></fA14><fA14 i1="14"><s1>Department of Medical Genetics and Child Development, University of Pecs</s1><s3>HUN</s3><sZ>17 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Neurology, University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>20 aut.</sZ></fA14><fA14 i1="17"><s1>Department of Neurology, St. Josef Hospital, University Hospital of Bochum</s1><s2>Bochum</s2><s3>DEU</s3><sZ>21 aut.</sZ></fA14><fA14 i1="18"><s1>Department of Neurology, University Hospital "Marqués de Valdecilla," CIBERNED</s1><s2>Santander</s2><s3>ESP</s3><sZ>22 aut.</sZ></fA14><fA14 i1="19"><s1>Department of Neurology, University Hospital of Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>23 aut.</sZ></fA14><fA14 i1="20"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>24 aut.</sZ></fA14><fA14 i1="21"><s1>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles</s1><s2>Brussels</s2><s3>BEL</s3><sZ>25 aut.</sZ></fA14><fA14 i1="22"><s1>Department of Neurology, University of Frankfurt</s1><s2>Frankfurt/M</s2><s3>DEU</s3><sZ>26 aut.</sZ></fA14><fA14 i1="23"><s1>Department of Neurology, University Clinic, RTHW Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>27 aut.</sZ></fA14><fA14 i1="24"><s1>Department of Neurology, Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University</s1><s2>DEU</s2><s3>DEU</s3><sZ>28 aut.</sZ></fA14><fA14 i1="25"><s1>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>29 aut.</sZ></fA14><fA20><s1>870-876</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000189767620160</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>41 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0228445</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Etat dépressif</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Depression</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Estado depresivo</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Ataxie spinocérébelleuse</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Spinocerebellar ataxia</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Ataxia spinocerebelosa</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Cervelet</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Cerebellum</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Cerebelo</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Prévalence</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Prevalence</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Prevalencia</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Trouble de l'humeur</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Mood disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Trastorno humor</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie héréditaire</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Genetic disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>43</s5></fC07><fN21><s1>150</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 11-0228445 INIST</NO><ET>Depression Comorbidity in Spinocerebellar Ataxia</ET><AU>SCHMITZ-HÜBSCH (Tanja); COUDERT (Mathieu); TEZENAS DU MONTCEL (Sophie); GIUNTI (Paola); LABRUM (Robyn); DURR (Alexandra); RIBAI (Pascale); CHARLES (Perrine); LINNEMANN (Christoph); SCHÖLS (Ludger); RAKOWICZ (Maryla); ROLA (Rafal); ZDZIENICKA (Elszbieta); FANCELLU (Roberto); MARIOTTI (Caterina); BALIKO (Lazlo); MELEGH (Bela); FILLA (Alessandro); SALVATORE (Elena); VAN DE WARRENBURG (Bart P. C.); SZYMANSKI (Sandra); INFANTE (Jon); TIMMANN (Dagmar); BOESCH (Sylvia); DEPONDT (Chantal); KANG (Jun-Suk); SCHULZ (Jörg B.); KLOPSTOCK (Thomas); LOSSNITZER (Nicole); LÖWE (Bernd); FRICK (Caroline); ROTTLÄNDER (Daniela); SCHLAEPFER (Thomas E.); KLOCKGETHER (Thomas)</AU><AF>Department of Neurology, University Hospital of Bonn/Bonn/Allemagne (1 aut., 34 aut.); Department of Biostatistics and Medical Informatics, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux/Paris/France (2 aut., 3 aut.); Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie/Paris/France (2 aut., 3 aut.); Department of Molecular Neuroscience, Institute of Neurology, Queen Square/London/Royaume-Uni (4 aut.); Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square/London/Royaume-Uni (5 aut.); INSERM, UMR_S679 Neurologie & Thérapeutique Expérimental/Paris/France (6 aut., 7 aut., 8 aut.); AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics/Paris/France (6 aut., 7 aut., 8 aut.); Department of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (9 aut., 10 aut.); Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology/Warsaw/Pologne (11 aut.); First Department of Neurology, Institute of Psychiatry and Neurology/Warsaw/Pologne (12 aut.); Department of Genetics, Institute of Psychiatry and Neurology/Warsaw/Pologne (13 aut.); Department of Biochemistry and Genetics, Fondazione-IRCCS, Istituto Neurologico Carlo Besta/Milan/Italie (14 aut., 15 aut.); Department of Neurology and Stroke, County Hospital/Veszprém/Hongrie (16 aut.); Department of Medical Genetics and Child Development, University of Pecs/Hongrie (17 aut.); Department of Neurology, University of Naples/Naples/Italie (18 aut., 19 aut.); Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center/Nijmegen/Pays-Bas (20 aut.); Department of Neurology, St. Josef Hospital, University Hospital of Bochum/Bochum/Allemagne (21 aut.); Department of Neurology, University Hospital "Marqués de Valdecilla," CIBERNED/Santander/Espagne (22 aut.); Department of Neurology, University Hospital of Essen/Essen/Allemagne (23 aut.); Department of Neurology, University of Innsbruck/Innsbruck/Autriche (24 aut.); Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles/Brussels/Belgique (25 aut.); Department of Neurology, University of Frankfurt/Frankfurt/M/Allemagne (26 aut.); Department of Neurology, University Clinic, RTHW Aachen/Aachen/Allemagne (27 aut.); Department of Neurology, Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University/DEU/Allemagne (28 aut.); Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg/Heidelberg/Allemagne (29 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 5; Pp. 870-876; Bibl. 41 ref.</SO><LA>Anglais</LA><EA>This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.</EA><CC>002B17; 002B17G</CC><FD>Etat dépressif; Pathologie du système nerveux; Ataxie spinocérébelleuse; Cervelet; Prévalence</FD><FG>Trouble de l'humeur; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central; Encéphale; Système nerveux central</FG><ED>Depression; Nervous system diseases; Spinocerebellar ataxia; Cerebellum; Prevalence</ED><EG>Mood disorder; Degenerative disease; Genetic disease; Central nervous system disease; Encephalon; Central nervous system</EG><SD>Estado depresivo; Sistema nervioso patología; Ataxia spinocerebelosa; Cerebelo; Prevalencia</SD><LO>INIST-20953.354000189767620160</LO><ID>11-0228445</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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