Milestones in Huntington Disease
Identifieur interne : 000564 ( PascalFrancis/Corpus ); précédent : 000563; suivant : 000565Milestones in Huntington Disease
Auteurs : Ira Shoulson ; Anne B. YoungSource :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done before we have a full understanding of the pathophysiology of the disease. Clinical research on biomarkers and clinical trials on potential neuroprotective agents are underway. Here we review our progress in these areas over the last 25 years and speculate on what the next 25 years may hold.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 11-0264664 INIST |
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ET : | Milestones in Huntington Disease |
AU : | SHOULSON (Ira); YOUNG (Anne B.) |
AF : | Program for Regulatory Science and Medicine, Georgetown University/Washington, District of Columbia/Etats-Unis (1 aut.); Harvard Medical School and Massachusetts General Hospital/Boston, Massachusetts/Etats-Unis (2 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 6; Pp. 1127-1133; Bibl. 81 ref. |
LA : | Anglais |
EA : | There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done before we have a full understanding of the pathophysiology of the disease. Clinical research on biomarkers and clinical trials on potential neuroprotective agents are underway. Here we review our progress in these areas over the last 25 years and speculate on what the next 25 years may hold. |
CC : | 002B17; 002B17G |
FD : | Chorée de Huntington; Pathologie du système nerveux; Traitement |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central |
ED : | Huntington disease; Nervous system diseases; Treatment |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease |
SD : | Corea Huntington; Sistema nervioso patología; Tratamiento |
LO : | INIST-20953.354000191622890180 |
ID : | 11-0264664 |
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Pascal:11-0264664Le document en format XML
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<front><div type="abstract" xml:lang="en">There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done before we have a full understanding of the pathophysiology of the disease. Clinical research on biomarkers and clinical trials on potential neuroprotective agents are underway. Here we review our progress in these areas over the last 25 years and speculate on what the next 25 years may hold.</div>
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<ET>Milestones in Huntington Disease</ET>
<AU>SHOULSON (Ira); YOUNG (Anne B.)</AU>
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