MovDisordV3, PascalFrancis, Corpus, bibRecord, 000340

Caffeine in Parkinson's Disease: A Pilot Open-Label, Dose-Escalation Study

Identifieur interne : 000340 ( PascalFrancis/Corpus ); précédent : 000339; suivant : 000341

Caffeine in Parkinson's Disease: A Pilot Open-Label, Dose-Escalation Study

Auteurs : Robert D. Altman ; Anthony E. Lang ; Ronald B. Postuma

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:12-0026979

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Caféine, Essai clinique.

English descriptors

KwdEn :
- Caffeine, Clinical trial, Nervous system diseases, Parkinson disease.

Abstract

Introduction: Epidemiologic studies consistently find an inverse association between caffeine use and PD. Numerous explanations exist, but are difficult to evaluate as caffeine's symptomatic effect and tolerability in PD are unknown. Patients and Methods: We designed an open-label, 6-week dose-escalation study of caffeine to establish dose tolerability and evaluate potential motor/nonmotor benefits. Caffeine was started at 200 mg daily and was increased to a maximum of 1,000 mg. Results: Of 25 subjects, 20 tolerated 200 mg, 17 tolerated 400 mg, 7 tolerated 800 mg, and 3 tolerated 1,000 mg. The most common adverse events were gastrointestinal discomfort, anxiety, and worsening/emerging tremor. At 400 mg daily, we found potential improvements in motor manifestations and somnolence (UPDRS III: -4.5 ± 4.6, P = 0.003; Epworth: -2.0 ± 3.0, P = 0.015). Conclusion: Maximum dose tolerability for caffeine in PD appears to be 100 to 200 mg BID. We found pilot preliminary evidence that caffeine may improve some motor and nonmotor aspects of PD, which must be confirmed in longer term, placebo-controlled, clinical trials.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
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A08	`01`	`1`	`ENG`	`@1 Caffeine in Parkinson's Disease: A Pilot Open-Label, Dose-Escalation Study`
A11	`01`	`1`		`@1 ALTMAN (Robert D.)`
A11	`02`	`1`		`@1 LANG (Anthony E.)`
A11	`03`	`1`		`@1 POSTUMA (Ronald B.)`
A14	`01`			`@1 Department of Neurology, McGill University, Montreal General Hospital @2 Montreal, Quebec @3 CAN @Z 1 aut. @Z 3 aut.`
A14	`02`			`@1 Morton and Gloria Shulman Movement Disorders center, Toronto Western Hospital @2 Toronto, Ontario @3 CAN @Z 2 aut.`
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A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 12-0026979`
A60				`@1 P @3 CC`
A61				`@0 A`
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C01	`01`		`ENG`	@0 Introduction: Epidemiologic studies consistently find an inverse association between caffeine use and PD. Numerous explanations exist, but are difficult to evaluate as caffeine's symptomatic effect and tolerability in PD are unknown. Patients and Methods: We designed an open-label, 6-week dose-escalation study of caffeine to establish dose tolerability and evaluate potential motor/nonmotor benefits. Caffeine was started at 200 mg daily and was increased to a maximum of 1,000 mg. Results: Of 25 subjects, 20 tolerated 200 mg, 17 tolerated 400 mg, 7 tolerated 800 mg, and 3 tolerated 1,000 mg. The most common adverse events were gastrointestinal discomfort, anxiety, and worsening/emerging tremor. At 400 mg daily, we found potential improvements in motor manifestations and somnolence (UPDRS III: -4.5 ± 4.6, P = 0.003; Epworth: -2.0 ± 3.0, P = 0.015). Conclusion: Maximum dose tolerability for caffeine in PD appears to be 100 to 200 mg BID. We found pilot preliminary evidence that caffeine may improve some motor and nonmotor aspects of PD, which must be confirmed in longer term, placebo-controlled, clinical trials.
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C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
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C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 009`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 12-0026979 INIST
ET :	Caffeine in Parkinson's Disease: A Pilot Open-Label, Dose-Escalation Study
AU :	ALTMAN (Robert D.); LANG (Anthony E.); POSTUMA (Ronald B.)
AF :	Department of Neurology, McGill University, Montreal General Hospital/Montreal, Quebec/Canada (1 aut., 3 aut.); Morton and Gloria Shulman Movement Disorders center, Toronto Western Hospital/Toronto, Ontario/Canada (2 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 13; Pp. 2427-2431; Bibl. 33 ref.
LA :	Anglais
EA :	Introduction: Epidemiologic studies consistently find an inverse association between caffeine use and PD. Numerous explanations exist, but are difficult to evaluate as caffeine's symptomatic effect and tolerability in PD are unknown. Patients and Methods: We designed an open-label, 6-week dose-escalation study of caffeine to establish dose tolerability and evaluate potential motor/nonmotor benefits. Caffeine was started at 200 mg daily and was increased to a maximum of 1,000 mg. Results: Of 25 subjects, 20 tolerated 200 mg, 17 tolerated 400 mg, 7 tolerated 800 mg, and 3 tolerated 1,000 mg. The most common adverse events were gastrointestinal discomfort, anxiety, and worsening/emerging tremor. At 400 mg daily, we found potential improvements in motor manifestations and somnolence (UPDRS III: -4.5 ± 4.6, P = 0.003; Epworth: -2.0 ± 3.0, P = 0.015). Conclusion: Maximum dose tolerability for caffeine in PD appears to be 100 to 200 mg BID. We found pilot preliminary evidence that caffeine may improve some motor and nonmotor aspects of PD, which must be confirmed in longer term, placebo-controlled, clinical trials.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Caféine; Essai clinique
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Caffeine; Clinical trial
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Cafeína; Ensayo clínico
LO :	INIST-20953.354000505925010200
ID :	12-0026979

Links to Exploration step

Pascal:12-0026979

Le document en format XML

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<front><div type="abstract" xml:lang="en">Introduction: Epidemiologic studies consistently find an inverse association between caffeine use and PD. Numerous explanations exist, but are difficult to evaluate as caffeine's symptomatic effect and tolerability in PD are unknown. Patients and Methods: We designed an open-label, 6-week dose-escalation study of caffeine to establish dose tolerability and evaluate potential motor/nonmotor benefits. Caffeine was started at 200 mg daily and was increased to a maximum of 1,000 mg. Results: Of 25 subjects, 20 tolerated 200 mg, 17 tolerated 400 mg, 7 tolerated 800 mg, and 3 tolerated 1,000 mg. The most common adverse events were gastrointestinal discomfort, anxiety, and worsening/emerging tremor. At 400 mg daily, we found potential improvements in motor manifestations and somnolence (UPDRS III: -4.5 ± 4.6, P = 0.003; Epworth: -2.0 ± 3.0, P = 0.015). Conclusion: Maximum dose tolerability for caffeine in PD appears to be 100 to 200 mg BID. We found pilot preliminary evidence that caffeine may improve some motor and nonmotor aspects of PD, which must be confirmed in longer term, placebo-controlled, clinical trials.</div>
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<ET>Caffeine in Parkinson's Disease: A Pilot Open-Label, Dose-Escalation Study</ET>
<AU>ALTMAN (Robert D.); LANG (Anthony E.); POSTUMA (Ronald B.)</AU>
<AF>Department of Neurology, McGill University, Montreal General Hospital/Montreal, Quebec/Canada (1 aut., 3 aut.); Morton and Gloria Shulman Movement Disorders center, Toronto Western Hospital/Toronto, Ontario/Canada (2 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
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<EA>Introduction: Epidemiologic studies consistently find an inverse association between caffeine use and PD. Numerous explanations exist, but are difficult to evaluate as caffeine's symptomatic effect and tolerability in PD are unknown. Patients and Methods: We designed an open-label, 6-week dose-escalation study of caffeine to establish dose tolerability and evaluate potential motor/nonmotor benefits. Caffeine was started at 200 mg daily and was increased to a maximum of 1,000 mg. Results: Of 25 subjects, 20 tolerated 200 mg, 17 tolerated 400 mg, 7 tolerated 800 mg, and 3 tolerated 1,000 mg. The most common adverse events were gastrointestinal discomfort, anxiety, and worsening/emerging tremor. At 400 mg daily, we found potential improvements in motor manifestations and somnolence (UPDRS III: -4.5 ± 4.6, P = 0.003; Epworth: -2.0 ± 3.0, P = 0.015). Conclusion: Maximum dose tolerability for caffeine in PD appears to be 100 to 200 mg BID. We found pilot preliminary evidence that caffeine may improve some motor and nonmotor aspects of PD, which must be confirmed in longer term, placebo-controlled, clinical trials.</EA>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Caffeine in Parkinson's Disease: A Pilot Open-Label, Dose-Escalation Study

Caffeine in Parkinson's Disease: A Pilot Open-Label, Dose-Escalation Study

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