MovDisordV3, PascalFrancis, Corpus, bibRecord, 000330

Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?

Identifieur interne : 000330 ( PascalFrancis/Corpus ); précédent : 000329; suivant : 000331

Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?

Auteurs : Christine Daniels ; Paul Krack ; Jens Volkmann ; Jan Raethjen ; Markus O. Pinsker ; Manja Kloss ; Volker Tronnier ; Alfons Schnitzler ; Lars Wojtecki ; Kai Bötzel ; Adrian Danek ; Rudiger Hilker ; Volker Sturm ; Andreas Kupsch ; Elfriede Karner ; Gunther Deuschl ; Karsten Witt

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:12-0051317

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Amélioration, Qualité de vie, Noyau sousthalamique, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Improvement, Nervous system diseases, Parkinson disease, Quality of life, Subthalamic nucleus.

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily "off" time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily "off" time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety.
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C03	`05`	`X`	`FRE`	`@0 Noyau sousthalamique @5 11`
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C03	`06`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
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C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 39`
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Format Inist (serveur)

NO :	PASCAL 12-0051317 INIST
ET :	Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?
AU :	DANIELS (Christine); KRACK (Paul); VOLKMANN (Jens); RAETHJEN (Jan); PINSKER (Markus O.); KLOSS (Manja); TRONNIER (Volker); SCHNITZLER (Alfons); WOJTECKI (Lars); BÖTZEL (Kai); DANEK (Adrian); HILKER (Rudiger); STURM (Volker); KUPSCH (Andreas); KARNER (Elfriede); DEUSCHL (Gunther); WITT (Karsten)
AF :	Department of Neurology, Christian-Albrechts-University/Kiel/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 16 aut., 17 aut.); Department of Neurosurgery, Christian-Albrechts-University/Kiel/Allemagne (5 aut.); Department of Neurology, Heidelberg University/Heidelberg/Allemagne (6 aut.); Department of Neurosurgery, Heidelberg University/Heidelberg/Allemagne (7 aut.); Department of Neurology, Heinrich Heine University/Dusseldorf/Allemagne (8 aut., 9 aut.); Department of Neurology, Ludwig-Maximilians-University/Munich/Allemagne (10 aut., 11 aut.); Department of Neurology, Cologne University/Cologne/Allemagne (12 aut.); Department of Neurosurgery, Cologne University/Cologne/Allemagne (13 aut.); Department of Neurology, Charité Hospital, Humboldt University/Berlin/Allemagne (14 aut.); Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (15 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 14; Pp. 2516-2521; Bibl. 15 ref.
LA :	Anglais
EA :	Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily "off" time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Amélioration; Qualité de vie; Noyau sousthalamique; Stimulation cérébrale profonde
FG :	Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Improvement; Quality of life; Subthalamic nucleus; Deep brain stimulation
EG :	Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Mejora; Calidad vida; Núcleo subtalámico
LO :	INIST-20953.354000508614760160
ID :	12-0051317

Links to Exploration step

Pascal:12-0051317

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?</title>
<author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
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<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
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<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
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<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
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<author><name sortKey="Pinsker, Markus O" sort="Pinsker, Markus O" uniqKey="Pinsker M" first="Markus O." last="Pinsker">Markus O. Pinsker</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurosurgery, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Heidelberg University</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Tronnier, Volker" sort="Tronnier, Volker" uniqKey="Tronnier V" first="Volker" last="Tronnier">Volker Tronnier</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurosurgery, Heidelberg University</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Heinrich Heine University</s1>
<s2>Dusseldorf</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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</author>
<author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Heinrich Heine University</s1>
<s2>Dusseldorf</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurology, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurology, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rudiger" last="Hilker">Rudiger Hilker</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Cologne University</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurosurgery, Cologne University</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Charité Hospital, Humboldt University</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Karner, Elfriede" sort="Karner, Elfriede" uniqKey="Karner E" first="Elfriede" last="Karner">Elfriede Karner</name>
<affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s2>Innsbruck</s2>
<s3>AUT</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Gunther" last="Deuschl">Gunther Deuschl</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Improvement</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Quality of life</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Amélioration</term>
<term>Qualité de vie</term>
<term>Noyau sousthalamique</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily "off" time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>DANIELS (Christine)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>KRACK (Paul)</s1>
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<fA11 i1="09" i2="1"><s1>WOJTECKI (Lars)</s1>
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<fA11 i1="10" i2="1"><s1>BÖTZEL (Kai)</s1>
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<fA11 i1="11" i2="1"><s1>DANEK (Adrian)</s1>
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<fA11 i1="15" i2="1"><s1>KARNER (Elfriede)</s1>
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<fA11 i1="16" i2="1"><s1>DEUSCHL (Gunther)</s1>
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<fA11 i1="17" i2="1"><s1>WITT (Karsten)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Neurosurgery, Christian-Albrechts-University</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurology, Heidelberg University</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurosurgery, Heidelberg University</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, Heinrich Heine University</s1>
<s2>Dusseldorf</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Neurology, Ludwig-Maximilians-University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<fA14 i1="07"><s1>Department of Neurology, Cologne University</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
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<fA14 i1="08"><s1>Department of Neurosurgery, Cologne University</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department of Neurology, Charité Hospital, Humboldt University</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s2>Innsbruck</s2>
<s3>AUT</s3>
<sZ>15 aut.</sZ>
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<fA20><s1>2516-2521</s1>
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<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>15 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0051317</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
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<fC01 i1="01" l="ENG"><s0>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily "off" time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
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<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
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<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Improvement</s0>
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<fC03 i1="04" i2="X" l="FRE"><s0>Qualité de vie</s0>
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<fC03 i1="04" i2="X" l="ENG"><s0>Quality of life</s0>
<s5>10</s5>
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<s5>10</s5>
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<s5>37</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
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<s5>41</s5>
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<s5>41</s5>
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<s5>42</s5>
</fC07>
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<s5>42</s5>
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<server><NO>PASCAL 12-0051317 INIST</NO>
<ET>Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?</ET>
<AU>DANIELS (Christine); KRACK (Paul); VOLKMANN (Jens); RAETHJEN (Jan); PINSKER (Markus O.); KLOSS (Manja); TRONNIER (Volker); SCHNITZLER (Alfons); WOJTECKI (Lars); BÖTZEL (Kai); DANEK (Adrian); HILKER (Rudiger); STURM (Volker); KUPSCH (Andreas); KARNER (Elfriede); DEUSCHL (Gunther); WITT (Karsten)</AU>
<AF>Department of Neurology, Christian-Albrechts-University/Kiel/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 16 aut., 17 aut.); Department of Neurosurgery, Christian-Albrechts-University/Kiel/Allemagne (5 aut.); Department of Neurology, Heidelberg University/Heidelberg/Allemagne (6 aut.); Department of Neurosurgery, Heidelberg University/Heidelberg/Allemagne (7 aut.); Department of Neurology, Heinrich Heine University/Dusseldorf/Allemagne (8 aut., 9 aut.); Department of Neurology, Ludwig-Maximilians-University/Munich/Allemagne (10 aut., 11 aut.); Department of Neurology, Cologne University/Cologne/Allemagne (12 aut.); Department of Neurosurgery, Cologne University/Cologne/Allemagne (13 aut.); Department of Neurology, Charité Hospital, Humboldt University/Berlin/Allemagne (14 aut.); Department of Neurology, Innsbruck Medical University/Innsbruck/Autriche (15 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2011; Vol. 26; No. 14; Pp. 2516-2521; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily "off" time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Amélioration; Qualité de vie; Noyau sousthalamique; Stimulation cérébrale profonde</FD>
<FG>Encéphale; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Improvement; Quality of life; Subthalamic nucleus; Deep brain stimulation</ED>
<EG>Encephalon; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Mejora; Calidad vida; Núcleo subtalámico</SD>
<LO>INIST-20953.354000508614760160</LO>
<ID>12-0051317</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?

Is Improvement in the Quality of Life After Subthalamic Nucleus Stimulation in Parkinson's Disease Predictable?

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