MovDisordV3, PascalFrancis, Corpus, bibRecord, 000302

Locomotion Speed Determines Gait Variability in Cerebellar Ataxia and Vestibular Failure

Identifieur interne : 000302 ( PascalFrancis/Corpus ); précédent : 000301; suivant : 000303

Locomotion Speed Determines Gait Variability in Cerebellar Ataxia and Vestibular Failure

Auteurs : Roman Schniepp ; Maximilian Wuehr ; Maximilian Neuhaeusser ; Maria Kamenova ; Konstantin Dimitriadis ; Thomas Klopstock ; M. Strupp ; Thomas Brandt ; Klaus Jahn

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0106492

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Locomotion, Vitesse déplacement, Variabilité, Ataxie cérébelleuse.

English descriptors

KwdEn :
- Cerebellar ataxia, Locomotion, Nervous system diseases, Speed, Variability.

Abstract

Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 27`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 Locomotion Speed Determines Gait Variability in Cerebellar Ataxia and Vestibular Failure`
A11	`01`	`1`		`@1 SCHNIEPP (Roman)`
A11	`02`	`1`		`@1 WUEHR (Maximilian)`
A11	`03`	`1`		`@1 NEUHAEUSSER (Maximilian)`
A11	`04`	`1`		`@1 KAMENOVA (Maria)`
A11	`05`	`1`		`@1 DIMITRIADIS (Konstantin)`
A11	`06`	`1`		`@1 KLOPSTOCK (Thomas)`
A11	`07`	`1`		`@1 STRUPP (M.)`
A11	`08`	`1`		`@1 BRANDT (Thomas)`
A11	`09`	`1`		`@1 JAHN (Klaus)`
A14	`01`			`@1 Department of Neurology, University of Munich @2 Munich @3 DEU @Z 1 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 9 aut.`
A14	`02`			`@1 Integrated Research and Treatment Center for Vertigo, Balance and Ocular Motor Disorders (IFB^LMU), University of Munich @2 Munich @3 DEU @Z 1 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut.`
A14	`03`			`@1 Graduate School of Systemic Neurosciences, University of Munich @2 Munich @3 DEU @Z 2 aut. @Z 3 aut.`
A14	`04`			`@1 Institute of Clinical Neurosciences, University of Munich @2 Munich @3 DEU @Z 8 aut.`
A20				`@1 125-131`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000508687520190`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 33 ref.`
A47	`01`	`1`		`@0 12-0106492`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Locomotion @5 09`
C03	`02`	`X`	`ENG`	`@0 Locomotion @5 09`
C03	`02`	`X`	`SPA`	`@0 Locomoción @5 09`
C03	`03`	`X`	`FRE`	`@0 Vitesse déplacement @5 10`
C03	`03`	`X`	`ENG`	`@0 Speed @5 10`
C03	`03`	`X`	`SPA`	`@0 Velocidad desplazamiento @5 10`
C03	`04`	`X`	`FRE`	`@0 Variabilité @5 11`
C03	`04`	`X`	`ENG`	`@0 Variability @5 11`
C03	`04`	`X`	`SPA`	`@0 Variabilidad @5 11`
C03	`05`	`X`	`FRE`	`@0 Ataxie cérébelleuse @2 NM @5 12`
C03	`05`	`X`	`ENG`	`@0 Cerebellar ataxia @2 NM @5 12`
C03	`05`	`X`	`SPA`	`@0 Ataxia cerebelosa @2 NM @5 12`
N21				`@1 079`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 12-0106492 INIST
ET :	Locomotion Speed Determines Gait Variability in Cerebellar Ataxia and Vestibular Failure
AU :	SCHNIEPP (Roman); WUEHR (Maximilian); NEUHAEUSSER (Maximilian); KAMENOVA (Maria); DIMITRIADIS (Konstantin); KLOPSTOCK (Thomas); STRUPP (M.); BRANDT (Thomas); JAHN (Klaus)
AF :	Department of Neurology, University of Munich/Munich/Allemagne (1 aut., 4 aut., 5 aut., 6 aut., 7 aut., 9 aut.); Integrated Research and Treatment Center for Vertigo, Balance and Ocular Motor Disorders (IFB^LMU), University of Munich/Munich/Allemagne (1 aut., 7 aut., 8 aut., 9 aut.); Graduate School of Systemic Neurosciences, University of Munich/Munich/Allemagne (2 aut., 3 aut.); Institute of Clinical Neurosciences, University of Munich/Munich/Allemagne (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 1; Pp. 125-131; Bibl. 33 ref.
LA :	Anglais
EA :	Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion.
CC :	002B17; 002B17G
FD :	Pathologie du système nerveux; Locomotion; Vitesse déplacement; Variabilité; Ataxie cérébelleuse
ED :	Nervous system diseases; Locomotion; Speed; Variability; Cerebellar ataxia
SD :	Sistema nervioso patología; Locomoción; Velocidad desplazamiento; Variabilidad; Ataxia cerebelosa
LO :	INIST-20953.354000508687520190
ID :	12-0106492

Links to Exploration step

Pascal:12-0106492

Le document en format XML

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<author><name sortKey="Brandt, Thomas" sort="Brandt, Thomas" uniqKey="Brandt T" first="Thomas" last="Brandt">Thomas Brandt</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellar ataxia</term>
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<term>Speed</term>
<term>Variability</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du   système nerveux</term>
<term>Locomotion</term>
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<front><div type="abstract" xml:lang="en">Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion.</div>
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<EA>Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion.</EA>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Locomotion Speed Determines Gait Variability in Cerebellar Ataxia and Vestibular Failure

Locomotion Speed Determines Gait Variability in Cerebellar Ataxia and Vestibular Failure

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