MovDisordV3, PascalFrancis, Corpus, bibRecord, 000256

Huntington's Disease: Objective Assessment of Posture-A Link Between Motor and Functional Deficits

Identifieur interne : 000256 ( PascalFrancis/Corpus ); précédent : 000255; suivant : 000257

Huntington's Disease: Objective Assessment of Posture-A Link Between Motor and Functional Deficits

Auteurs : Ralf Reilmann ; Silke Rumpf ; Heike Beckmann ; Raphael Koch ; Erich B. Ringelstein ; Herwig W. Lange

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0183678

Descripteurs français

Pascal (Inist)
- Chorée de Huntington, Trouble moteur, Déficit fonctionnel, Pathologie du système nerveux, Posture, Pronostic, Contrôle moteur, Noyau gris central.

English descriptors

KwdEn :
- Basal ganglion, Functional deficit, Huntington disease, Motor control, Motor system disorder, Nervous system diseases, Posture, Prognosis.

Abstract

Background: Postural deficits in Huntington's disease are linked to functional impairment. We investigated whether assessment of center-of-mass variability using posturography provides objective and quantitative measures that correlate to the severity of motor phenotype, functional measures, and genotype as assessed by a disease burden score (based on repeat length and age). In addition, we investigated whether withdrawing visual feedback facilitates the detection of postural deficits. Methods: Using a force plate, the ability of symptomatic Huntington's disease patients (n = 34) and controls (n = 20) to stand as stably as possible was assessed in eyes-open and eyes-closed conditions. Results: All posturographic measures (DISTANCE, VELOCITY, and SURFACE of centre-of-mass mobility) were increased in patients and correlated to (1) the UHDRS Total Motor Score, (2) the UHDRS Total Functional Capacity, (3) the UHDRS Functional Assessment Score, and (4) the disease burden score. Correlations to motor and functional measures were stronger when visual feedback was provided. Conclusions: Posturography may provide useful objective and quantitative measures of postural motor dysfunction in Huntington's disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 27`
A06				`@2 4`
A08	`01`	`1`	`ENG`	`@1 Huntington's Disease: Objective Assessment of Posture-A Link Between Motor and Functional Deficits`
A11	`01`	`1`		`@1 REILMANN (Ralf)`
A11	`02`	`1`		`@1 RUMPF (Silke)`
A11	`03`	`1`		`@1 BECKMANN (Heike)`
A11	`04`	`1`		`@1 KOCH (Raphael)`
A11	`05`	`1`		`@1 RINGELSTEIN (Erich B.)`
A11	`06`	`1`		`@1 LANGE (Herwig W.)`
A14	`01`			`@1 Department of Neurology, UKM, University of Muenster, Albert-Schweitzer-Campus 1 @2 Muenster @3 DEU @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Institute of Biostatistics and Clinical Research, University of Muenster, Albert-Schweitzer-Campus 1 @2 Muenster @3 DEU @Z 4 aut.`
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A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000194678450200`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 19 ref.`
A47	`01`	`1`		`@0 12-0183678`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Background: Postural deficits in Huntington's disease are linked to functional impairment. We investigated whether assessment of center-of-mass variability using posturography provides objective and quantitative measures that correlate to the severity of motor phenotype, functional measures, and genotype as assessed by a disease burden score (based on repeat length and age). In addition, we investigated whether withdrawing visual feedback facilitates the detection of postural deficits. Methods: Using a force plate, the ability of symptomatic Huntington's disease patients (n = 34) and controls (n = 20) to stand as stably as possible was assessed in eyes-open and eyes-closed conditions. Results: All posturographic measures (DISTANCE, VELOCITY, and SURFACE of centre-of-mass mobility) were increased in patients and correlated to (1) the UHDRS Total Motor Score, (2) the UHDRS Total Functional Capacity, (3) the UHDRS Functional Assessment Score, and (4) the disease burden score. Correlations to motor and functional measures were stronger when visual feedback was provided. Conclusions: Posturography may provide useful objective and quantitative measures of postural motor dysfunction in Huntington's disease.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Chorée de Huntington @5 01`
C03	`01`	`X`	`ENG`	`@0 Huntington disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Corea Huntington @5 01`
C03	`02`	`X`	`FRE`	`@0 Trouble moteur @5 02`
C03	`02`	`X`	`ENG`	`@0 Motor system disorder @5 02`
C03	`02`	`X`	`SPA`	`@0 Trastorno motor @5 02`
C03	`03`	`X`	`FRE`	`@0 Déficit fonctionnel @5 03`
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C03	`03`	`X`	`SPA`	`@0 Deficiencia funcional @5 03`
C03	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 04`
C03	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 04`
C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Posture @5 09`
C03	`05`	`X`	`ENG`	`@0 Posture @5 09`
C03	`05`	`X`	`SPA`	`@0 Postura @5 09`
C03	`06`	`X`	`FRE`	`@0 Pronostic @5 10`
C03	`06`	`X`	`ENG`	`@0 Prognosis @5 10`
C03	`06`	`X`	`SPA`	`@0 Pronóstico @5 10`
C03	`07`	`X`	`FRE`	`@0 Contrôle moteur @5 11`
C03	`07`	`X`	`ENG`	`@0 Motor control @5 11`
C03	`07`	`X`	`SPA`	`@0 Control motor @5 11`
C03	`08`	`X`	`FRE`	`@0 Noyau gris central @5 12`
C03	`08`	`X`	`ENG`	`@0 Basal ganglion @5 12`
C03	`08`	`X`	`SPA`	`@0 Núcleo basal @5 12`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie héréditaire @5 40`
C07	`04`	`X`	`ENG`	`@0 Genetic disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad hereditaria @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 43`
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C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 43`
C07	`07`	`X`	`FRE`	`@0 Encéphale @5 44`
C07	`07`	`X`	`ENG`	`@0 Encephalon @5 44`
C07	`07`	`X`	`SPA`	`@0 Encéfalo @5 44`
C07	`08`	`X`	`FRE`	`@0 Système nerveux central @5 45`
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C07	`08`	`X`	`SPA`	`@0 Sistema nervioso central @5 45`
N21				`@1 142`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 12-0183678 INIST
ET :	Huntington's Disease: Objective Assessment of Posture-A Link Between Motor and Functional Deficits
AU :	REILMANN (Ralf); RUMPF (Silke); BECKMANN (Heike); KOCH (Raphael); RINGELSTEIN (Erich B.); LANGE (Herwig W.)
AF :	Department of Neurology, UKM, University of Muenster, Albert-Schweitzer-Campus 1/Muenster/Allemagne (1 aut., 2 aut., 3 aut., 5 aut., 6 aut.); Institute of Biostatistics and Clinical Research, University of Muenster, Albert-Schweitzer-Campus 1/Muenster/Allemagne (4 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 4; Pp. 555-559; Bibl. 19 ref.
LA :	Anglais
EA :	Background: Postural deficits in Huntington's disease are linked to functional impairment. We investigated whether assessment of center-of-mass variability using posturography provides objective and quantitative measures that correlate to the severity of motor phenotype, functional measures, and genotype as assessed by a disease burden score (based on repeat length and age). In addition, we investigated whether withdrawing visual feedback facilitates the detection of postural deficits. Methods: Using a force plate, the ability of symptomatic Huntington's disease patients (n = 34) and controls (n = 20) to stand as stably as possible was assessed in eyes-open and eyes-closed conditions. Results: All posturographic measures (DISTANCE, VELOCITY, and SURFACE of centre-of-mass mobility) were increased in patients and correlated to (1) the UHDRS Total Motor Score, (2) the UHDRS Total Functional Capacity, (3) the UHDRS Functional Assessment Score, and (4) the disease burden score. Correlations to motor and functional measures were stronger when visual feedback was provided. Conclusions: Posturography may provide useful objective and quantitative measures of postural motor dysfunction in Huntington's disease.
CC :	002B17; 002B17G
FD :	Chorée de Huntington; Trouble moteur; Déficit fonctionnel; Pathologie du système nerveux; Posture; Pronostic; Contrôle moteur; Noyau gris central
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du système nerveux central; Trouble neurologique; Encéphale; Système nerveux central
ED :	Huntington disease; Motor system disorder; Functional deficit; Nervous system diseases; Posture; Prognosis; Motor control; Basal ganglion
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease; Neurological disorder; Encephalon; Central nervous system
SD :	Corea Huntington; Trastorno motor; Deficiencia funcional; Sistema nervioso patología; Postura; Pronóstico; Control motor; Núcleo basal
LO :	INIST-20953.354000194678450200
ID :	12-0183678

Links to Exploration step

Pascal:12-0183678

Le document en format XML

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<term>Nervous system diseases</term>
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<front><div type="abstract" xml:lang="en">Background: Postural deficits in Huntington's disease are linked to functional impairment. We investigated whether assessment of center-of-mass variability using posturography provides objective and quantitative measures that correlate to the severity of motor phenotype, functional measures, and genotype as assessed by a disease burden score (based on repeat length and age). In addition, we investigated whether withdrawing visual feedback facilitates the detection of postural deficits. Methods: Using a force plate, the ability of symptomatic Huntington's disease patients (n = 34) and controls (n = 20) to stand as stably as possible was assessed in eyes-open and eyes-closed conditions. Results: All posturographic measures (DISTANCE, VELOCITY, and SURFACE of centre-of-mass mobility) were increased in patients and correlated to (1) the UHDRS Total Motor Score, (2) the UHDRS Total Functional Capacity, (3) the UHDRS Functional Assessment Score, and (4) the disease burden score. Correlations to motor and functional measures were stronger when visual feedback was provided. Conclusions: Posturography may provide useful objective and quantitative measures of postural motor dysfunction in Huntington's disease.</div>
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<fC01 i1="01" l="ENG"><s0>Background: Postural deficits in Huntington's disease are linked to functional impairment. We investigated whether assessment of center-of-mass variability using posturography provides objective and quantitative measures that correlate to the severity of motor phenotype, functional measures, and genotype as assessed by a disease burden score (based on repeat length and age). In addition, we investigated whether withdrawing visual feedback facilitates the detection of postural deficits. Methods: Using a force plate, the ability of symptomatic Huntington's disease patients (n = 34) and controls (n = 20) to stand as stably as possible was assessed in eyes-open and eyes-closed conditions. Results: All posturographic measures (DISTANCE, VELOCITY, and SURFACE of centre-of-mass mobility) were increased in patients and correlated to (1) the UHDRS Total Motor Score, (2) the UHDRS Total Functional Capacity, (3) the UHDRS Functional Assessment Score, and (4) the disease burden score. Correlations to motor and functional measures were stronger when visual feedback was provided. Conclusions: Posturography may provide useful objective and quantitative measures of postural motor dysfunction in Huntington's disease.</s0>
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<server><NO>PASCAL 12-0183678 INIST</NO>
<ET>Huntington's Disease: Objective Assessment of Posture-A Link Between Motor and Functional Deficits</ET>
<AU>REILMANN (Ralf); RUMPF (Silke); BECKMANN (Heike); KOCH (Raphael); RINGELSTEIN (Erich B.); LANGE (Herwig W.)</AU>
<AF>Department of Neurology, UKM, University of Muenster, Albert-Schweitzer-Campus 1/Muenster/Allemagne (1 aut., 2 aut., 3 aut., 5 aut., 6 aut.); Institute of Biostatistics and Clinical Research, University of Muenster, Albert-Schweitzer-Campus 1/Muenster/Allemagne (4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 4; Pp. 555-559; Bibl. 19 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Postural deficits in Huntington's disease are linked to functional impairment. We investigated whether assessment of center-of-mass variability using posturography provides objective and quantitative measures that correlate to the severity of motor phenotype, functional measures, and genotype as assessed by a disease burden score (based on repeat length and age). In addition, we investigated whether withdrawing visual feedback facilitates the detection of postural deficits. Methods: Using a force plate, the ability of symptomatic Huntington's disease patients (n = 34) and controls (n = 20) to stand as stably as possible was assessed in eyes-open and eyes-closed conditions. Results: All posturographic measures (DISTANCE, VELOCITY, and SURFACE of centre-of-mass mobility) were increased in patients and correlated to (1) the UHDRS Total Motor Score, (2) the UHDRS Total Functional Capacity, (3) the UHDRS Functional Assessment Score, and (4) the disease burden score. Correlations to motor and functional measures were stronger when visual feedback was provided. Conclusions: Posturography may provide useful objective and quantitative measures of postural motor dysfunction in Huntington's disease.</EA>
<CC>002B17; 002B17G</CC>
<FD>Chorée de Huntington; Trouble moteur; Déficit fonctionnel; Pathologie du   système nerveux; Posture; Pronostic; Contrôle moteur; Noyau gris central</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie du   système nerveux central; Trouble neurologique; Encéphale; Système nerveux central</FG>
<ED>Huntington disease; Motor system disorder; Functional deficit; Nervous system diseases; Posture; Prognosis; Motor control; Basal ganglion</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease; Neurological disorder; Encephalon; Central nervous system</EG>
<SD>Corea Huntington; Trastorno motor; Deficiencia funcional; Sistema nervioso patología; Postura; Pronóstico; Control motor; Núcleo basal</SD>
<LO>INIST-20953.354000194678450200</LO>
<ID>12-0183678</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Huntington's Disease: Objective Assessment of Posture-A Link Between Motor and Functional Deficits

Huntington's Disease: Objective Assessment of Posture-A Link Between Motor and Functional Deficits

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