MovDisordV3, PascalFrancis, Corpus, bibRecord, 000224

Evaluation of Periodic Limb Movements in a Putative Animal Model of Restless Leg Syndrome

Identifieur interne : 000224 ( PascalFrancis/Corpus ); précédent : 000223; suivant : 000225

Evaluation of Periodic Limb Movements in a Putative Animal Model of Restless Leg Syndrome

Auteurs : Cleide Lopes ; Andrea M. Esteves ; Roberto Frussa-Filho ; Sergio Tufik ; Marco Tulio De Mello

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0198675

Descripteurs français

Pascal (Inist)
- Syndrome des jambes sans repos, Trouble du sommeil, Pathologie du système nerveux, Evaluation, Modèle animal, Sommeil.

English descriptors

KwdEn :
- Animal model, Evaluation, Nervous system diseases, Restless legs syndrome, Sleep, Sleep disorder.

Abstract

Restless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electro-physiologically. The aim of this study was to examine the sleep-wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6-hydroxydopamine (6-OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate-buffered saline (PBS). A control group that did not receive any injection was also included. Wakefulness percentages were generated for 4-hour segments of the dark period, yielding the following 3 bins: 7 PM to 11 PM, 11 PM to 3 AM, and 3 PM to 7 PM. Additionally, slow wave sleep, paradoxical sleep, wakefulness, and limb movements were evaluated over the entire 12 hours of the light/dark cycle. All A11-lesioned rats exhibited an increased percentage of wakefulness during the last block of the dark period, as would be expected for an animal model of this syndrome. In addition, at all time points after lesioning, these animals presented increased frequencies of limb movement during both the light and the dark periods. These alterations were reversed by the acute administration of the dopaminergic agonist pramipexole. This animal model strengthens the notion that 6-OHDA-induced A11 lesions can be a valid animal model for RLS and PLM.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`05`	`1`		`@1 DE MELLO (Marco Tulio)`
A14	`01`			`@1 Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP) @2 São Paulo @3 BRA @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut.`
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C01	`01`		`ENG`	@0 Restless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electro-physiologically. The aim of this study was to examine the sleep-wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6-hydroxydopamine (6-OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate-buffered saline (PBS). A control group that did not receive any injection was also included. Wakefulness percentages were generated for 4-hour segments of the dark period, yielding the following 3 bins: 7 PM to 11 PM, 11 PM to 3 AM, and 3 PM to 7 PM. Additionally, slow wave sleep, paradoxical sleep, wakefulness, and limb movements were evaluated over the entire 12 hours of the light/dark cycle. All A11-lesioned rats exhibited an increased percentage of wakefulness during the last block of the dark period, as would be expected for an animal model of this syndrome. In addition, at all time points after lesioning, these animals presented increased frequencies of limb movement during both the light and the dark periods. These alterations were reversed by the acute administration of the dopaminergic agonist pramipexole. This animal model strengthens the notion that 6-OHDA-induced A11 lesions can be a valid animal model for RLS and PLM.
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Format Inist (serveur)

NO :	PASCAL 12-0198675 INIST
ET :	Evaluation of Periodic Limb Movements in a Putative Animal Model of Restless Leg Syndrome
AU :	LOPES (Cleide); ESTEVES (Andrea M.); FRUSSA-FILHO (Roberto); TUFIK (Sergio); DE MELLO (Marco Tulio)
AF :	Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP)/São Paulo/Brésil (1 aut., 2 aut., 4 aut., 5 aut.); Department of Pharmacology, Universidade Federal de São Paulo (UNIFESP)/São P/Brésil (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 3; Pp. 413-420; Bibl. 33 ref.
LA :	Anglais
EA :	Restless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electro-physiologically. The aim of this study was to examine the sleep-wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6-hydroxydopamine (6-OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate-buffered saline (PBS). A control group that did not receive any injection was also included. Wakefulness percentages were generated for 4-hour segments of the dark period, yielding the following 3 bins: 7 PM to 11 PM, 11 PM to 3 AM, and 3 PM to 7 PM. Additionally, slow wave sleep, paradoxical sleep, wakefulness, and limb movements were evaluated over the entire 12 hours of the light/dark cycle. All A11-lesioned rats exhibited an increased percentage of wakefulness during the last block of the dark period, as would be expected for an animal model of this syndrome. In addition, at all time points after lesioning, these animals presented increased frequencies of limb movement during both the light and the dark periods. These alterations were reversed by the acute administration of the dopaminergic agonist pramipexole. This animal model strengthens the notion that 6-OHDA-induced A11 lesions can be a valid animal model for RLS and PLM.
CC :	002B17; 002B17A01
FD :	Syndrome des jambes sans repos; Trouble du sommeil; Pathologie du système nerveux; Evaluation; Modèle animal; Sommeil
FG :	Trouble neurologique; Trouble de la sensibilité; Cycle veille sommeil
ED :	Restless legs syndrome; Sleep disorder; Nervous system diseases; Evaluation; Animal model; Sleep
EG :	Neurological disorder; Sensitivity disorder; Sleep wake cycle
SD :	Acroparestesia nocturna; Trastorno sueño; Sistema nervioso patología; Evaluación; Modelo animal; Sueño
LO :	INIST-20953.354000506923350150
ID :	12-0198675

Links to Exploration step

Pascal:12-0198675

Le document en format XML

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<front><div type="abstract" xml:lang="en">Restless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electro-physiologically. The aim of this study was to examine the sleep-wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6-hydroxydopamine (6-OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate-buffered saline (PBS). A control group that did not receive any injection was also included. Wakefulness percentages were generated for 4-hour segments of the dark period, yielding the following 3 bins: 7 PM to 11 PM, 11 PM to 3 AM, and 3 PM to 7 PM. Additionally, slow wave sleep, paradoxical sleep, wakefulness, and limb movements were evaluated over the entire 12 hours of the light/dark cycle. All A11-lesioned rats exhibited an increased percentage of wakefulness during the last block of the dark period, as would be expected for an animal model of this syndrome. In addition, at all time points after lesioning, these animals presented increased frequencies of limb movement during both the light and the dark periods. These alterations were reversed by the acute administration of the dopaminergic agonist pramipexole. This animal model strengthens the notion that 6-OHDA-induced A11 lesions can be a valid animal model for RLS and PLM.</div>
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<fC03 i1="06" i2="X" l="FRE"><s0>Sommeil</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Sleep</s0>
<s5>11</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Sueño</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>38</s5>
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<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Trouble de la sensibilité</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Sensitivity disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno sensibilidad</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Cycle veille sommeil</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Sleep wake cycle</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Ciclo sueño vigilia</s0>
<s5>40</s5>
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<server><NO>PASCAL 12-0198675 INIST</NO>
<ET>Evaluation of Periodic Limb Movements in a Putative Animal Model of Restless Leg Syndrome</ET>
<AU>LOPES (Cleide); ESTEVES (Andrea M.); FRUSSA-FILHO (Roberto); TUFIK (Sergio); DE MELLO (Marco Tulio)</AU>
<AF>Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP)/São Paulo/Brésil (1 aut., 2 aut., 4 aut., 5 aut.); Department of Pharmacology, Universidade Federal de São Paulo (UNIFESP)/São P/Brésil (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 3; Pp. 413-420; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>Restless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electro-physiologically. The aim of this study was to examine the sleep-wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6-hydroxydopamine (6-OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate-buffered saline (PBS). A control group that did not receive any injection was also included. Wakefulness percentages were generated for 4-hour segments of the dark period, yielding the following 3 bins: 7 PM to 11 PM, 11 PM to 3 AM, and 3 PM to 7 PM. Additionally, slow wave sleep, paradoxical sleep, wakefulness, and limb movements were evaluated over the entire 12 hours of the light/dark cycle. All A11-lesioned rats exhibited an increased percentage of wakefulness during the last block of the dark period, as would be expected for an animal model of this syndrome. In addition, at all time points after lesioning, these animals presented increased frequencies of limb movement during both the light and the dark periods. These alterations were reversed by the acute administration of the dopaminergic agonist pramipexole. This animal model strengthens the notion that 6-OHDA-induced A11 lesions can be a valid animal model for RLS and PLM.</EA>
<CC>002B17; 002B17A01</CC>
<FD>Syndrome des jambes sans repos; Trouble du sommeil; Pathologie du système nerveux; Evaluation; Modèle animal; Sommeil</FD>
<FG>Trouble neurologique; Trouble de la sensibilité; Cycle veille sommeil</FG>
<ED>Restless legs syndrome; Sleep disorder; Nervous system diseases; Evaluation; Animal model; Sleep</ED>
<EG>Neurological disorder; Sensitivity disorder; Sleep wake cycle</EG>
<SD>Acroparestesia nocturna; Trastorno sueño; Sistema nervioso patología; Evaluación; Modelo animal; Sueño</SD>
<LO>INIST-20953.354000506923350150</LO>
<ID>12-0198675</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Evaluation of Periodic Limb Movements in a Putative Animal Model of Restless Leg Syndrome

Evaluation of Periodic Limb Movements in a Putative Animal Model of Restless Leg Syndrome

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