MovDisordV3, PascalFrancis, Corpus, bibRecord, 000185

Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease

Identifieur interne : 000185 ( PascalFrancis/Corpus ); précédent : 000184; suivant : 000186

Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease

Auteurs : Alfonso Fasano ; Lucia Ricciardi ; Anna Rita Bentivoglio ; Carlotta Canavese ; Giovanna Zorzi ; Igor Petrovic ; Nikola Kresojevic ; Vladimir S. Kostic ; Marina Svetel ; Norbert Kovacs ; Istvan Balas ; Agathe Roubertie ; Devendra Mishra ; Paolo Mariotti ; Teresa Temudo ; Nardo Nardocci

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0248755

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Pronostic, Midazolam, Pantothenate kinase.

English descriptors

KwdEn :
- Dystonia, Midazolam, Nervous system diseases, Pantothenate kinase, Prognosis.

Abstract

Background: Status dystonicus (SD) is a rare, lifethreatening disorder characterized by acute worsening of generalized dystonia. Methods: This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature. Results: Eighty-nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%). Conclusions: The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 27`
A06				`@2 6`
A08	`01`	`1`	`ENG`	`@1 Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease`
A11	`01`	`1`		`@1 FASANO (Alfonso)`
A11	`02`	`1`		`@1 RICCIARDI (Lucia)`
A11	`03`	`1`		`@1 BENTIVOGLIO (Anna Rita)`
A11	`04`	`1`		`@1 CANAVESE (Carlotta)`
A11	`05`	`1`		`@1 ZORZI (Giovanna)`
A11	`06`	`1`		`@1 PETROVIC (Igor)`
A11	`07`	`1`		`@1 KRESOJEVIC (Nikola)`
A11	`08`	`1`		`@1 KOSTIC (Vladimir S.)`
A11	`09`	`1`		`@1 SVETEL (Marina)`
A11	`10`	`1`		`@1 KOVACS (Norbert)`
A11	`11`	`1`		`@1 BALAS (Istvan)`
A11	`12`	`1`		`@1 ROUBERTIE (Agathe)`
A11	`13`	`1`		`@1 MISHRA (Devendra)`
A11	`14`	`1`		`@1 MARIOTTI (Paolo)`
A11	`15`	`1`		`@1 TEMUDO (Teresa)`
A11	`16`	`1`		`@1 NARDOCCI (Nardo)`
A14	`01`			`@1 Istituto di Neurologia, Università Cattolica del Sacro Cuore @2 Rome @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut.`
A14	`02`			`@1 AFaR-Fatebenefratelli Association for Biomedical Research, Neuromed Institute @2 Rome @3 ITA @Z 1 aut.`
A14	`03`			`@1 Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina @2 Messina @3 ITA @Z 2 aut.`
A14	`04`			`@1 Neurological Institute "Carlo Besta @2 Milan @3 ITA @Z 4 aut. @Z 5 aut. @Z 16 aut.`
A14	`05`			`@1 Institute of Neurology, Clinical Center of Serbia, School of Medicine @2 Belgrade @3 SRB @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut.`
A14	`06`			`@1 Department of Neurology, University of Pecs @2 Pecs @3 HUN @Z 10 aut. @Z 11 aut.`
A14	`07`			`@1 CHU Montpellier, Hôpital Gui de Chauliac, Service de Neuropédiatrie @2 Montpellier @3 FRA @Z 12 aut.`
A14	`08`			`@1 INSERM U827, Institut Universitaire de Recherche Clinique @2 Montpellier @3 FRA @Z 12 aut.`
A14	`09`			`@1 Department of Pediatrics, Maulana Azad Medical College and LN Hospital, University of Delhi @2 Delhi @3 IND @Z 13 aut.`
A14	`10`			`@1 Istituto di Neuropsichiatria Infantile, Università Cattolica del Sacro Cuore @2 Rome @3 ITA @Z 14 aut.`
A14	`11`			`@1 Unidade de Neuropediatria, Serviço de Pediatria, Hospital Geral de Santo Antonio @2 Porto @3 PRT @Z 15 aut.`
A20				`@1 783-788`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000507771510220`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 31 ref.`
A47	`01`	`1`		`@0 12-0248755`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Background: Status dystonicus (SD) is a rare, lifethreatening disorder characterized by acute worsening of generalized dystonia. Methods: This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature. Results: Eighty-nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%). Conclusions: The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Dystonie @5 01`
C03	`01`	`X`	`ENG`	`@0 Dystonia @5 01`
C03	`01`	`X`	`SPA`	`@0 Distonía @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Pronostic @5 09`
C03	`03`	`X`	`ENG`	`@0 Prognosis @5 09`
C03	`03`	`X`	`SPA`	`@0 Pronóstico @5 09`
C03	`04`	`X`	`FRE`	`@0 Midazolam @2 NK @2 FR @5 10`
C03	`04`	`X`	`ENG`	`@0 Midazolam @2 NK @2 FR @5 10`
C03	`04`	`X`	`SPA`	`@0 Midazolam @2 NK @2 FR @5 10`
C03	`05`	`X`	`FRE`	`@0 Pantothenate kinase @2 FE @5 11`
C03	`05`	`X`	`ENG`	`@0 Pantothenate kinase @2 FE @5 11`
C03	`05`	`X`	`SPA`	`@0 Pantothenate kinase @2 FE @5 11`
C07	`01`	`X`	`FRE`	`@0 Transferases @2 FE`
C07	`01`	`X`	`ENG`	`@0 Transferases @2 FE`
C07	`01`	`X`	`SPA`	`@0 Transferases @2 FE`
C07	`02`	`X`	`FRE`	`@0 Enzyme @2 FE`
C07	`02`	`X`	`ENG`	`@0 Enzyme @2 FE`
C07	`02`	`X`	`SPA`	`@0 Enzima @2 FE`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 37`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 37`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 37`
C07	`04`	`X`	`FRE`	`@0 Mouvement involontaire @5 38`
C07	`04`	`X`	`ENG`	`@0 Involuntary movement @5 38`
C07	`04`	`X`	`SPA`	`@0 Movimiento involuntario @5 38`
C07	`05`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 39`
C07	`05`	`X`	`ENG`	`@0 Striated muscle disease @5 39`
C07	`05`	`X`	`SPA`	`@0 Músculo estriado patología @5 39`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 41`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 41`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 41`
C07	`07`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 42`
C07	`07`	`X`	`ENG`	`@0 Cerebral disorder @5 42`
C07	`07`	`X`	`SPA`	`@0 Encéfalo patología @5 42`
C07	`08`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 43`
C07	`08`	`X`	`ENG`	`@0 Central nervous system disease @5 43`
C07	`08`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 43`
N21				`@1 191`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 12-0248755 INIST
ET :	Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease
AU :	FASANO (Alfonso); RICCIARDI (Lucia); BENTIVOGLIO (Anna Rita); CANAVESE (Carlotta); ZORZI (Giovanna); PETROVIC (Igor); KRESOJEVIC (Nikola); KOSTIC (Vladimir S.); SVETEL (Marina); KOVACS (Norbert); BALAS (Istvan); ROUBERTIE (Agathe); MISHRA (Devendra); MARIOTTI (Paolo); TEMUDO (Teresa); NARDOCCI (Nardo)
AF :	Istituto di Neurologia, Università Cattolica del Sacro Cuore/Rome/Italie (1 aut., 2 aut., 3 aut.); AFaR-Fatebenefratelli Association for Biomedical Research, Neuromed Institute/Rome/Italie (1 aut.); Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina/Messina/Italie (2 aut.); Neurological Institute "Carlo Besta/Milan/Italie (4 aut., 5 aut., 16 aut.); Institute of Neurology, Clinical Center of Serbia, School of Medicine/Belgrade/Serbie (6 aut., 7 aut., 8 aut., 9 aut.); Department of Neurology, University of Pecs/Pecs/Hongrie (10 aut., 11 aut.); CHU Montpellier, Hôpital Gui de Chauliac, Service de Neuropédiatrie/Montpellier/France (12 aut.); INSERM U827, Institut Universitaire de Recherche Clinique/Montpellier/France (12 aut.); Department of Pediatrics, Maulana Azad Medical College and LN Hospital, University of Delhi/Delhi/Inde (13 aut.); Istituto di Neuropsichiatria Infantile, Università Cattolica del Sacro Cuore/Rome/Italie (14 aut.); Unidade de Neuropediatria, Serviço de Pediatria, Hospital Geral de Santo Antonio/Porto/Portugal (15 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 6; Pp. 783-788; Bibl. 31 ref.
LA :	Anglais
EA :	Background: Status dystonicus (SD) is a rare, lifethreatening disorder characterized by acute worsening of generalized dystonia. Methods: This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature. Results: Eighty-nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%). Conclusions: The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome.
CC :	002B17; 002B17G
FD :	Dystonie; Pathologie du système nerveux; Pronostic; Midazolam; Pantothenate kinase
FG :	Transferases; Enzyme; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du système nerveux central
ED :	Dystonia; Nervous system diseases; Prognosis; Midazolam; Pantothenate kinase
EG :	Transferases; Enzyme; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease
SD :	Distonía; Sistema nervioso patología; Pronóstico; Midazolam; Pantothenate kinase
LO :	INIST-20953.354000507771510220
ID :	12-0248755

Links to Exploration step

Pascal:12-0248755

Le document en format XML

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<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
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<author><name sortKey="Zorzi, Giovanna" sort="Zorzi, Giovanna" uniqKey="Zorzi G" first="Giovanna" last="Zorzi">Giovanna Zorzi</name>
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<author><name sortKey="Kresojevic, Nikola" sort="Kresojevic, Nikola" uniqKey="Kresojevic N" first="Nikola" last="Kresojevic">Nikola Kresojevic</name>
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<author><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S." last="Kostic">Vladimir S. Kostic</name>
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<author><name sortKey="Kovacs, Norbert" sort="Kovacs, Norbert" uniqKey="Kovacs N" first="Norbert" last="Kovacs">Norbert Kovacs</name>
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<author><name sortKey="Balas, Istvan" sort="Balas, Istvan" uniqKey="Balas I" first="Istvan" last="Balas">Istvan Balas</name>
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<author><name sortKey="Roubertie, Agathe" sort="Roubertie, Agathe" uniqKey="Roubertie A" first="Agathe" last="Roubertie">Agathe Roubertie</name>
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<author><name sortKey="Mishra, Devendra" sort="Mishra, Devendra" uniqKey="Mishra D" first="Devendra" last="Mishra">Devendra Mishra</name>
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<author><name sortKey="Mariotti, Paolo" sort="Mariotti, Paolo" uniqKey="Mariotti P" first="Paolo" last="Mariotti">Paolo Mariotti</name>
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<author><name sortKey="Temudo, Teresa" sort="Temudo, Teresa" uniqKey="Temudo T" first="Teresa" last="Temudo">Teresa Temudo</name>
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<author><name sortKey="Nardocci, Nardo" sort="Nardocci, Nardo" uniqKey="Nardocci N" first="Nardo" last="Nardocci">Nardo Nardocci</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease</title>
<author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Università Cattolica del Sacro Cuore</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>AFaR-Fatebenefratelli Association for Biomedical Research, Neuromed Institute</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ricciardi, Lucia" sort="Ricciardi, Lucia" uniqKey="Ricciardi L" first="Lucia" last="Ricciardi">Lucia Ricciardi</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Università Cattolica del Sacro Cuore</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
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<affiliation><inist:fA14 i1="03"><s1>Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation><inist:fA14 i1="01"><s1>Istituto di Neurologia, Università Cattolica del Sacro Cuore</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Canavese, Carlotta" sort="Canavese, Carlotta" uniqKey="Canavese C" first="Carlotta" last="Canavese">Carlotta Canavese</name>
<affiliation><inist:fA14 i1="04"><s1>Neurological Institute "Carlo Besta</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Zorzi, Giovanna" sort="Zorzi, Giovanna" uniqKey="Zorzi G" first="Giovanna" last="Zorzi">Giovanna Zorzi</name>
<affiliation><inist:fA14 i1="04"><s1>Neurological Institute "Carlo Besta</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Petrovic, Igor" sort="Petrovic, Igor" uniqKey="Petrovic I" first="Igor" last="Petrovic">Igor Petrovic</name>
<affiliation><inist:fA14 i1="05"><s1>Institute of Neurology, Clinical Center of Serbia, School of Medicine</s1>
<s2>Belgrade</s2>
<s3>SRB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kresojevic, Nikola" sort="Kresojevic, Nikola" uniqKey="Kresojevic N" first="Nikola" last="Kresojevic">Nikola Kresojevic</name>
<affiliation><inist:fA14 i1="05"><s1>Institute of Neurology, Clinical Center of Serbia, School of Medicine</s1>
<s2>Belgrade</s2>
<s3>SRB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S." last="Kostic">Vladimir S. Kostic</name>
<affiliation><inist:fA14 i1="05"><s1>Institute of Neurology, Clinical Center of Serbia, School of Medicine</s1>
<s2>Belgrade</s2>
<s3>SRB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Svetel, Marina" sort="Svetel, Marina" uniqKey="Svetel M" first="Marina" last="Svetel">Marina Svetel</name>
<affiliation><inist:fA14 i1="05"><s1>Institute of Neurology, Clinical Center of Serbia, School of Medicine</s1>
<s2>Belgrade</s2>
<s3>SRB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kovacs, Norbert" sort="Kovacs, Norbert" uniqKey="Kovacs N" first="Norbert" last="Kovacs">Norbert Kovacs</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurology, University of Pecs</s1>
<s2>Pecs</s2>
<s3>HUN</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Balas, Istvan" sort="Balas, Istvan" uniqKey="Balas I" first="Istvan" last="Balas">Istvan Balas</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurology, University of Pecs</s1>
<s2>Pecs</s2>
<s3>HUN</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Roubertie, Agathe" sort="Roubertie, Agathe" uniqKey="Roubertie A" first="Agathe" last="Roubertie">Agathe Roubertie</name>
<affiliation><inist:fA14 i1="07"><s1>CHU Montpellier, Hôpital Gui de Chauliac, Service de Neuropédiatrie</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="08"><s1>INSERM U827, Institut Universitaire de Recherche Clinique</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mishra, Devendra" sort="Mishra, Devendra" uniqKey="Mishra D" first="Devendra" last="Mishra">Devendra Mishra</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Pediatrics, Maulana Azad Medical College and LN Hospital, University of Delhi</s1>
<s2>Delhi</s2>
<s3>IND</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mariotti, Paolo" sort="Mariotti, Paolo" uniqKey="Mariotti P" first="Paolo" last="Mariotti">Paolo Mariotti</name>
<affiliation><inist:fA14 i1="10"><s1>Istituto di Neuropsichiatria Infantile, Università Cattolica del Sacro Cuore</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Temudo, Teresa" sort="Temudo, Teresa" uniqKey="Temudo T" first="Teresa" last="Temudo">Teresa Temudo</name>
<affiliation><inist:fA14 i1="11"><s1>Unidade de Neuropediatria, Serviço de Pediatria, Hospital Geral de Santo Antonio</s1>
<s2>Porto</s2>
<s3>PRT</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Nardocci, Nardo" sort="Nardocci, Nardo" uniqKey="Nardocci N" first="Nardo" last="Nardocci">Nardo Nardocci</name>
<affiliation><inist:fA14 i1="04"><s1>Neurological Institute "Carlo Besta</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dystonia</term>
<term>Midazolam</term>
<term>Nervous system diseases</term>
<term>Pantothenate kinase</term>
<term>Prognosis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Pronostic</term>
<term>Midazolam</term>
<term>Pantothenate kinase</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Status dystonicus (SD) is a rare, lifethreatening disorder characterized by acute worsening of generalized dystonia. Methods: This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature. Results: Eighty-nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%). Conclusions: The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome.</div>
</front>
</TEI>
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<fA08 i1="01" i2="1" l="ENG"><s1>Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>FASANO (Alfonso)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>RICCIARDI (Lucia)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BENTIVOGLIO (Anna Rita)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>CANAVESE (Carlotta)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>ZORZI (Giovanna)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>PETROVIC (Igor)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KRESOJEVIC (Nikola)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>KOSTIC (Vladimir S.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>SVETEL (Marina)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>KOVACS (Norbert)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>BALAS (Istvan)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>ROUBERTIE (Agathe)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>MISHRA (Devendra)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>MARIOTTI (Paolo)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>TEMUDO (Teresa)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>NARDOCCI (Nardo)</s1>
</fA11>
<fA14 i1="01"><s1>Istituto di Neurologia, Università Cattolica del Sacro Cuore</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>AFaR-Fatebenefratelli Association for Biomedical Research, Neuromed Institute</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Neurological Institute "Carlo Besta</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Institute of Neurology, Clinical Center of Serbia, School of Medicine</s1>
<s2>Belgrade</s2>
<s3>SRB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Neurology, University of Pecs</s1>
<s2>Pecs</s2>
<s3>HUN</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>CHU Montpellier, Hôpital Gui de Chauliac, Service de Neuropédiatrie</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>INSERM U827, Institut Universitaire de Recherche Clinique</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department of Pediatrics, Maulana Azad Medical College and LN Hospital, University of Delhi</s1>
<s2>Delhi</s2>
<s3>IND</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Istituto di Neuropsichiatria Infantile, Università Cattolica del Sacro Cuore</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Unidade de Neuropediatria, Serviço de Pediatria, Hospital Geral de Santo Antonio</s1>
<s2>Porto</s2>
<s3>PRT</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA20><s1>783-788</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
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<s5>354000507771510220</s5>
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<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>31 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0248755</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: Status dystonicus (SD) is a rare, lifethreatening disorder characterized by acute worsening of generalized dystonia. Methods: This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature. Results: Eighty-nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%). Conclusions: The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Dystonie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Dystonia</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Distonía</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>09</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Midazolam</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Midazolam</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Midazolam</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Pantothenate kinase</s0>
<s2>FE</s2>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Pantothenate kinase</s0>
<s2>FE</s2>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Pantothenate kinase</s0>
<s2>FE</s2>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Transferases</s0>
<s2>FE</s2>
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<fC07 i1="01" i2="X" l="SPA"><s0>Transferases</s0>
<s2>FE</s2>
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<fC07 i1="02" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>37</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>37</s5>
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<fC07 i1="04" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>38</s5>
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<fC07 i1="04" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>38</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>38</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du muscle strié</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Striated muscle disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Músculo estriado patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>41</s5>
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<s5>41</s5>
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<s5>41</s5>
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<s5>42</s5>
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<s5>42</s5>
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<s5>42</s5>
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<s5>43</s5>
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<server><NO>PASCAL 12-0248755 INIST</NO>
<ET>Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease</ET>
<AU>FASANO (Alfonso); RICCIARDI (Lucia); BENTIVOGLIO (Anna Rita); CANAVESE (Carlotta); ZORZI (Giovanna); PETROVIC (Igor); KRESOJEVIC (Nikola); KOSTIC (Vladimir S.); SVETEL (Marina); KOVACS (Norbert); BALAS (Istvan); ROUBERTIE (Agathe); MISHRA (Devendra); MARIOTTI (Paolo); TEMUDO (Teresa); NARDOCCI (Nardo)</AU>
<AF>Istituto di Neurologia, Università Cattolica del Sacro Cuore/Rome/Italie (1 aut., 2 aut., 3 aut.); AFaR-Fatebenefratelli Association for Biomedical Research, Neuromed Institute/Rome/Italie (1 aut.); Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina/Messina/Italie (2 aut.); Neurological Institute "Carlo Besta/Milan/Italie (4 aut., 5 aut., 16 aut.); Institute of Neurology, Clinical Center of Serbia, School of Medicine/Belgrade/Serbie (6 aut., 7 aut., 8 aut., 9 aut.); Department of Neurology, University of Pecs/Pecs/Hongrie (10 aut., 11 aut.); CHU Montpellier, Hôpital Gui de Chauliac, Service de Neuropédiatrie/Montpellier/France (12 aut.); INSERM U827, Institut Universitaire de Recherche Clinique/Montpellier/France (12 aut.); Department of Pediatrics, Maulana Azad Medical College and LN Hospital, University of Delhi/Delhi/Inde (13 aut.); Istituto di Neuropsichiatria Infantile, Università Cattolica del Sacro Cuore/Rome/Italie (14 aut.); Unidade de Neuropediatria, Serviço de Pediatria, Hospital Geral de Santo Antonio/Porto/Portugal (15 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 6; Pp. 783-788; Bibl. 31 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Status dystonicus (SD) is a rare, lifethreatening disorder characterized by acute worsening of generalized dystonia. Methods: This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature. Results: Eighty-nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%). Conclusions: The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome.</EA>
<CC>002B17; 002B17G</CC>
<FD>Dystonie; Pathologie du   système nerveux; Pronostic; Midazolam; Pantothenate kinase</FD>
<FG>Transferases; Enzyme; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du   système nerveux central</FG>
<ED>Dystonia; Nervous system diseases; Prognosis; Midazolam; Pantothenate kinase</ED>
<EG>Transferases; Enzyme; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease</EG>
<SD>Distonía; Sistema nervioso patología; Pronóstico; Midazolam; Pantothenate kinase</SD>
<LO>INIST-20953.354000507771510220</LO>
<ID>12-0248755</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease

Status Dystonicus: Predictors of Outcome and Progression Patterns of Underlying Disease

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