MovDisordV3, PascalFrancis, Corpus, bibRecord, 000153

Psychosis in Parkinson's Disease Without Dementia: Common and Comorbid With Other Non-Motor Symptoms

Identifieur interne : 000153 ( PascalFrancis/Corpus ); précédent : 000152; suivant : 000154

Psychosis in Parkinson's Disease Without Dementia: Common and Comorbid With Other Non-Motor Symptoms

Auteurs : Angela H. Lee ; Daniel Weintraub

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0280058

Descripteurs français

Pascal (Inist)
- Psychose, Maladie de Parkinson, Démence, Trouble moteur, Pathologie du système nerveux.

English descriptors

KwdEn :
- Dementia, Motor system disorder, Nervous system diseases, Parkinson disease, Psychosis.

Abstract

Psychosis in Parkinson's disease (PD) is common and associated with a range of negative outcomes. Dementia and psychosis are highly correlated in PD, but the frequency and correlates of psychosis in patients without cognitive impairment are not well understood. One hundred and ninety-one non-demented PD patients at two movement disorders centers participated in a study of neuropsychiatric complications in PD and completed a detailed neurological and neuropsychiatric assessment, including the rater-administered Parkinson Psychosis Rating Scale for hallucinations, delusions, and minor symptoms of psychosis (illusions and misidentification of persons). Psychotic symptoms were present in 21.5% of the sample. Visual hallucinations were most common (13.6%), followed by auditory hallucinations (6.8%), illusions or misidentification of people (7.3%), and paranoid ideation (4.7%). Visual hallucinations and illusions or misidentification of people were the most common comorbid symptoms (3.1%), Depression (P = 0.01) and rapid eye movement behavior disorder symptoms (P = 0.03) were associated with psychosis in a multivariable model. The odds of experiencing psychotic symptoms were approximately five times higher in patients with comorbid disorders of depression and sleep-wakefulness. Even in patients without global cognitive impairment, psychosis in PD is common and most highly correlated with other non-motor symptoms. Screening for psychosis should occur at all stages of PD as part of a broad non-motor assessment. In addition, these findings suggest a common neural substrate for disturbances of perception, mood, sleep-wakefulness, and incipient cognitive decline in PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 12-0280058 INIST
ET :	Psychosis in Parkinson's Disease Without Dementia: Common and Comorbid With Other Non-Motor Symptoms
AU :	LEE (Angela H.); WEINTRAUB (Daniel)
AF :	Perelman School of Medicine at the University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (1 aut.); Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Department of Neurology, Perelman School of Medicine at the University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Philadelphia Veterans Affairs Medical Center, Parkinson's Disease Research, Education, and Clinical Center/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Philadelphia Veterans Affairs Medical Center, Mental Illness Research, Education, and Clinical Center/Philadelphia, Pennsylvania/Etats-Unis (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 7; Pp. 858-863; Bibl. 42 ref.
LA :	Anglais
EA :	Psychosis in Parkinson's disease (PD) is common and associated with a range of negative outcomes. Dementia and psychosis are highly correlated in PD, but the frequency and correlates of psychosis in patients without cognitive impairment are not well understood. One hundred and ninety-one non-demented PD patients at two movement disorders centers participated in a study of neuropsychiatric complications in PD and completed a detailed neurological and neuropsychiatric assessment, including the rater-administered Parkinson Psychosis Rating Scale for hallucinations, delusions, and minor symptoms of psychosis (illusions and misidentification of persons). Psychotic symptoms were present in 21.5% of the sample. Visual hallucinations were most common (13.6%), followed by auditory hallucinations (6.8%), illusions or misidentification of people (7.3%), and paranoid ideation (4.7%). Visual hallucinations and illusions or misidentification of people were the most common comorbid symptoms (3.1%), Depression (P = 0.01) and rapid eye movement behavior disorder symptoms (P = 0.03) were associated with psychosis in a multivariable model. The odds of experiencing psychotic symptoms were approximately five times higher in patients with comorbid disorders of depression and sleep-wakefulness. Even in patients without global cognitive impairment, psychosis in PD is common and most highly correlated with other non-motor symptoms. Screening for psychosis should occur at all stages of PD as part of a broad non-motor assessment. In addition, these findings suggest a common neural substrate for disturbances of perception, mood, sleep-wakefulness, and incipient cognitive decline in PD.
CC :	002B17; 002B17G
FD :	Psychose; Maladie de Parkinson; Démence; Trouble moteur; Pathologie du système nerveux
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Trouble neurologique
ED :	Psychosis; Parkinson disease; Dementia; Motor system disorder; Nervous system diseases
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Neurological disorder
SD :	Psicosis; Parkinson enfermedad; Demencia; Trastorno motor; Sistema nervioso patología
LO :	INIST-20953.354000508307110080
ID :	12-0280058

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Pascal:12-0280058

Le document en format XML

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<front><div type="abstract" xml:lang="en">Psychosis in Parkinson's disease (PD) is common and associated with a range of negative outcomes. Dementia and psychosis are highly correlated in PD, but the frequency and correlates of psychosis in patients without cognitive impairment are not well understood. One hundred and ninety-one non-demented PD patients at two movement disorders centers participated in a study of neuropsychiatric complications in PD and completed a detailed neurological and neuropsychiatric assessment, including the rater-administered Parkinson Psychosis Rating Scale for hallucinations, delusions, and minor symptoms of psychosis (illusions and misidentification of persons). Psychotic symptoms were present in 21.5% of the sample. Visual hallucinations were most common (13.6%), followed by auditory hallucinations (6.8%), illusions or misidentification of people (7.3%), and paranoid ideation (4.7%). Visual hallucinations and illusions or misidentification of people were the most common comorbid symptoms (3.1%), Depression (P = 0.01) and rapid eye movement behavior disorder symptoms (P = 0.03) were associated with psychosis in a multivariable model. The odds of experiencing psychotic symptoms were approximately five times higher in patients with comorbid disorders of depression and sleep-wakefulness. Even in patients without global cognitive impairment, psychosis in PD is common and most highly correlated with other non-motor symptoms. Screening for psychosis should occur at all stages of PD as part of a broad non-motor assessment. In addition, these findings suggest a common neural substrate for disturbances of perception, mood, sleep-wakefulness, and incipient cognitive decline in PD.</div>
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<server><NO>PASCAL 12-0280058 INIST</NO>
<ET>Psychosis in Parkinson's Disease Without Dementia: Common and Comorbid With Other Non-Motor Symptoms</ET>
<AU>LEE (Angela H.); WEINTRAUB (Daniel)</AU>
<AF>Perelman School of Medicine at the University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (1 aut.); Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Department of Neurology, Perelman School of Medicine at the University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Philadelphia Veterans Affairs Medical Center, Parkinson's Disease Research, Education, and Clinical Center/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Philadelphia Veterans Affairs Medical Center, Mental Illness Research, Education, and Clinical Center/Philadelphia, Pennsylvania/Etats-Unis (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 7; Pp. 858-863; Bibl. 42 ref.</SO>
<LA>Anglais</LA>
<EA>Psychosis in Parkinson's disease (PD) is common and associated with a range of negative outcomes. Dementia and psychosis are highly correlated in PD, but the frequency and correlates of psychosis in patients without cognitive impairment are not well understood. One hundred and ninety-one non-demented PD patients at two movement disorders centers participated in a study of neuropsychiatric complications in PD and completed a detailed neurological and neuropsychiatric assessment, including the rater-administered Parkinson Psychosis Rating Scale for hallucinations, delusions, and minor symptoms of psychosis (illusions and misidentification of persons). Psychotic symptoms were present in 21.5% of the sample. Visual hallucinations were most common (13.6%), followed by auditory hallucinations (6.8%), illusions or misidentification of people (7.3%), and paranoid ideation (4.7%). Visual hallucinations and illusions or misidentification of people were the most common comorbid symptoms (3.1%), Depression (P = 0.01) and rapid eye movement behavior disorder symptoms (P = 0.03) were associated with psychosis in a multivariable model. The odds of experiencing psychotic symptoms were approximately five times higher in patients with comorbid disorders of depression and sleep-wakefulness. Even in patients without global cognitive impairment, psychosis in PD is common and most highly correlated with other non-motor symptoms. Screening for psychosis should occur at all stages of PD as part of a broad non-motor assessment. In addition, these findings suggest a common neural substrate for disturbances of perception, mood, sleep-wakefulness, and incipient cognitive decline in PD.</EA>
<CC>002B17; 002B17G</CC>
<FD>Psychose; Maladie de Parkinson; Démence; Trouble moteur; Pathologie du   système nerveux</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Trouble neurologique</FG>
<ED>Psychosis; Parkinson disease; Dementia; Motor system disorder; Nervous system diseases</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Neurological disorder</EG>
<SD>Psicosis; Parkinson enfermedad; Demencia; Trastorno motor; Sistema nervioso patología</SD>
<LO>INIST-20953.354000508307110080</LO>
<ID>12-0280058</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Psychosis in Parkinson's Disease Without Dementia: Common and Comorbid With Other Non-Motor Symptoms

Psychosis in Parkinson's Disease Without Dementia: Common and Comorbid With Other Non-Motor Symptoms

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