MovDisordV3, PascalFrancis, Corpus, bibRecord, 000090

Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease

Identifieur interne : 000090 ( PascalFrancis/Corpus ); précédent : 000089; suivant : 000091

Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease

Auteurs : Monika Pötter-Nerger ; Martin M. Reich ; James G. Colebatch ; G. Deuschl ; Jens Volkmann

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0369636

Descripteurs français

Pascal (Inist)
- Syndrome vestibulaire, Maladie de Parkinson, Pathologie du système nerveux, Dopa, Potentiel évoqué, Réflexe.

English descriptors

KwdEn :
- Dopa, Evoked potential, Nervous system diseases, Parkinson disease, Reflex, Vestibular syndrome.

Abstract

Postural disturbances in advanced Parkinson's disease are less responsive to therapy than other cardinal motor signs. The vestibulocollic reflex represents one brain-stem neuronal circuit involved in postural adjustments. The objective of this study was to investigate the vestibulocollic reflex in parkinsonian patients and the effects of subthalamic stimulation and dopa by recording vestibular-evoked myogenic potentials. After overnight withdrawal of medication, 20 patients with Parkinson's disease with (6 men, 4 women; mean age, 64.4 ± 2.2 years) or without (8 men, 2 women; mean age, 62.7 ± 3.9 years) implanted subthalamic electrodes in different treatment conditions were compared with 10 age-matched controls (5 men, 5 women; mean age, 59.6 ± 2.4 years). Vestibular-evoked myogenic potentials were recorded by electromyographic surface electrodes applied to both sternocleidomastoid muscles (band-pass filter, 8-1600 Hz; sampling rate, 5 kHz) and averaged in response to bilateral auditory tone bursts (120 dB SPL; sine waves, 7 ms; 1000 Hz) applied through earphones. Adjusted vestibular-evoked myogenic potential amplitudes were significantly smaller in parkinsonian patients than in controls, in particular in patients without surgery. Administration of dopa, but not subthalamic stimulation, significantly increased amplitudes. Onset latencies were similar for all groups and treatment conditions. Decreased vestibular-evoked myogenic potential amplitudes in parkinsonian patients suggest reduced vestibular nuclei excitability within the brain stem, which is modulated by dopa but not by subthalamic stimulation. This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 REICH (Martin M.)`
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C01	`01`		`ENG`	@0 Postural disturbances in advanced Parkinson's disease are less responsive to therapy than other cardinal motor signs. The vestibulocollic reflex represents one brain-stem neuronal circuit involved in postural adjustments. The objective of this study was to investigate the vestibulocollic reflex in parkinsonian patients and the effects of subthalamic stimulation and dopa by recording vestibular-evoked myogenic potentials. After overnight withdrawal of medication, 20 patients with Parkinson's disease with (6 men, 4 women; mean age, 64.4 ± 2.2 years) or without (8 men, 2 women; mean age, 62.7 ± 3.9 years) implanted subthalamic electrodes in different treatment conditions were compared with 10 age-matched controls (5 men, 5 women; mean age, 59.6 ± 2.4 years). Vestibular-evoked myogenic potentials were recorded by electromyographic surface electrodes applied to both sternocleidomastoid muscles (band-pass filter, 8-1600 Hz; sampling rate, 5 kHz) and averaged in response to bilateral auditory tone bursts (120 dB SPL; sine waves, 7 ms; 1000 Hz) applied through earphones. Adjusted vestibular-evoked myogenic potential amplitudes were significantly smaller in parkinsonian patients than in controls, in particular in patients without surgery. Administration of dopa, but not subthalamic stimulation, significantly increased amplitudes. Onset latencies were similar for all groups and treatment conditions. Decreased vestibular-evoked myogenic potential amplitudes in parkinsonian patients suggest reduced vestibular nuclei excitability within the brain stem, which is modulated by dopa but not by subthalamic stimulation. This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances.
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C03	`01`	`X`	`ENG`	`@0 Vestibular syndrome @5 01`
C03	`01`	`X`	`SPA`	`@0 Vestibular síndrome @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 02`
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C03	`05`	`X`	`FRE`	`@0 Potentiel évoqué @5 10`
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C03	`05`	`X`	`SPA`	`@0 Potencial evocado @5 10`
C03	`06`	`X`	`FRE`	`@0 Réflexe @5 11`
C03	`06`	`X`	`ENG`	`@0 Reflex @5 11`
C03	`06`	`X`	`SPA`	`@0 Reflejo @5 11`
C07	`01`	`X`	`FRE`	`@0 Pathologie ORL @5 37`
C07	`01`	`X`	`ENG`	`@0 ENT disease @5 37`
C07	`01`	`X`	`SPA`	`@0 ORL patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'oreille interne @5 39`
C07	`02`	`X`	`ENG`	`@0 Internal ear disease @5 39`
C07	`02`	`X`	`SPA`	`@0 Oido interno patología @5 39`
C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 40`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 40`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 40`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 41`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 42`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 42`
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C07	`07`	`X`	`FRE`	`@0 Electrophysiologie @5 44`
C07	`07`	`X`	`ENG`	`@0 Electrophysiology @5 44`
C07	`07`	`X`	`SPA`	`@0 Electrofisiología @5 44`
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N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 12-0369636 INIST
ET :	Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease
AU :	PÖTTER-NERGER (Monika); REICH (Martin M.); COLEBATCH (James G.); DEUSCHL (G.); VOLKMANN (Jens)
AF :	Department of Neurology, Christian-Albrecht-University/Kiel/Allemagne (1 aut., 2 aut., 4 aut., 5 aut.); Prince of Wales Clinical School and Medical Research Institute, University New South Wales/Sydney/Australie (3 aut.); Department of Neurology, Julius-Maximilian- University/Würzburg/Allemagne (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 10; Pp. 1268-1275; Bibl. 36 ref.
LA :	Anglais
EA :	Postural disturbances in advanced Parkinson's disease are less responsive to therapy than other cardinal motor signs. The vestibulocollic reflex represents one brain-stem neuronal circuit involved in postural adjustments. The objective of this study was to investigate the vestibulocollic reflex in parkinsonian patients and the effects of subthalamic stimulation and dopa by recording vestibular-evoked myogenic potentials. After overnight withdrawal of medication, 20 patients with Parkinson's disease with (6 men, 4 women; mean age, 64.4 ± 2.2 years) or without (8 men, 2 women; mean age, 62.7 ± 3.9 years) implanted subthalamic electrodes in different treatment conditions were compared with 10 age-matched controls (5 men, 5 women; mean age, 59.6 ± 2.4 years). Vestibular-evoked myogenic potentials were recorded by electromyographic surface electrodes applied to both sternocleidomastoid muscles (band-pass filter, 8-1600 Hz; sampling rate, 5 kHz) and averaged in response to bilateral auditory tone bursts (120 dB SPL; sine waves, 7 ms; 1000 Hz) applied through earphones. Adjusted vestibular-evoked myogenic potential amplitudes were significantly smaller in parkinsonian patients than in controls, in particular in patients without surgery. Administration of dopa, but not subthalamic stimulation, significantly increased amplitudes. Onset latencies were similar for all groups and treatment conditions. Decreased vestibular-evoked myogenic potential amplitudes in parkinsonian patients suggest reduced vestibular nuclei excitability within the brain stem, which is modulated by dopa but not by subthalamic stimulation. This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances.
CC :	002B17; 002B17G
FD :	Syndrome vestibulaire; Maladie de Parkinson; Pathologie du système nerveux; Dopa; Potentiel évoqué; Réflexe
FG :	Pathologie ORL; Pathologie de l'oreille interne; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Electrophysiologie
ED :	Vestibular syndrome; Parkinson disease; Nervous system diseases; Dopa; Evoked potential; Reflex
EG :	ENT disease; Internal ear disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Electrophysiology
SD :	Vestibular síndrome; Parkinson enfermedad; Sistema nervioso patología; Dopa; Potencial evocado; Reflejo
LO :	INIST-20953.354000502011860140
ID :	12-0369636

Links to Exploration step

Pascal:12-0369636

Le document en format XML

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<front><div type="abstract" xml:lang="en">Postural disturbances in advanced Parkinson's disease are less responsive to therapy than other cardinal motor signs. The vestibulocollic reflex represents one brain-stem neuronal circuit involved in postural adjustments. The objective of this study was to investigate the vestibulocollic reflex in parkinsonian patients and the effects of subthalamic stimulation and dopa by recording vestibular-evoked myogenic potentials. After overnight withdrawal of medication, 20 patients with Parkinson's disease with (6 men, 4 women; mean age, 64.4 ± 2.2 years) or without (8 men, 2 women; mean age, 62.7 ± 3.9 years) implanted subthalamic electrodes in different treatment conditions were compared with 10 age-matched controls (5 men, 5 women; mean age, 59.6 ± 2.4 years). Vestibular-evoked myogenic potentials were recorded by electromyographic surface electrodes applied to both sternocleidomastoid muscles (band-pass filter, 8-1600 Hz; sampling rate, 5 kHz) and averaged in response to bilateral auditory tone bursts (120 dB SPL; sine waves, 7 ms; 1000 Hz) applied through earphones. Adjusted vestibular-evoked myogenic potential amplitudes were significantly smaller in parkinsonian patients than in controls, in particular in patients without surgery. Administration of dopa, but not subthalamic stimulation, significantly increased amplitudes. Onset latencies were similar for all groups and treatment conditions. Decreased vestibular-evoked myogenic potential amplitudes in parkinsonian patients suggest reduced vestibular nuclei excitability within the brain stem, which is modulated by dopa but not by subthalamic stimulation. This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances.</div>
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<fC03 i1="01" i2="X" l="FRE"><s0>Syndrome vestibulaire</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Vestibular syndrome</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Vestibular síndrome</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Potentiel évoqué</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Evoked potential</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Potencial evocado</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Réflexe</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Reflex</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Reflejo</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie ORL</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>ENT disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>ORL patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'oreille interne</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Internal ear disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Oido interno patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Electrophysiologie</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Electrophysiology</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Electrofisiología</s0>
<s5>44</s5>
</fC07>
<fN21><s1>289</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0369636 INIST</NO>
<ET>Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease</ET>
<AU>PÖTTER-NERGER (Monika); REICH (Martin M.); COLEBATCH (James G.); DEUSCHL (G.); VOLKMANN (Jens)</AU>
<AF>Department of Neurology, Christian-Albrecht-University/Kiel/Allemagne (1 aut., 2 aut., 4 aut., 5 aut.); Prince of Wales Clinical School and Medical Research Institute, University New South Wales/Sydney/Australie (3 aut.); Department of Neurology, Julius-Maximilian- University/Würzburg/Allemagne (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 10; Pp. 1268-1275; Bibl. 36 ref.</SO>
<LA>Anglais</LA>
<EA>Postural disturbances in advanced Parkinson's disease are less responsive to therapy than other cardinal motor signs. The vestibulocollic reflex represents one brain-stem neuronal circuit involved in postural adjustments. The objective of this study was to investigate the vestibulocollic reflex in parkinsonian patients and the effects of subthalamic stimulation and dopa by recording vestibular-evoked myogenic potentials. After overnight withdrawal of medication, 20 patients with Parkinson's disease with (6 men, 4 women; mean age, 64.4 ± 2.2 years) or without (8 men, 2 women; mean age, 62.7 ± 3.9 years) implanted subthalamic electrodes in different treatment conditions were compared with 10 age-matched controls (5 men, 5 women; mean age, 59.6 ± 2.4 years). Vestibular-evoked myogenic potentials were recorded by electromyographic surface electrodes applied to both sternocleidomastoid muscles (band-pass filter, 8-1600 Hz; sampling rate, 5 kHz) and averaged in response to bilateral auditory tone bursts (120 dB SPL; sine waves, 7 ms; 1000 Hz) applied through earphones. Adjusted vestibular-evoked myogenic potential amplitudes were significantly smaller in parkinsonian patients than in controls, in particular in patients without surgery. Administration of dopa, but not subthalamic stimulation, significantly increased amplitudes. Onset latencies were similar for all groups and treatment conditions. Decreased vestibular-evoked myogenic potential amplitudes in parkinsonian patients suggest reduced vestibular nuclei excitability within the brain stem, which is modulated by dopa but not by subthalamic stimulation. This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances.</EA>
<CC>002B17; 002B17G</CC>
<FD>Syndrome vestibulaire; Maladie de Parkinson; Pathologie du système nerveux; Dopa; Potentiel évoqué; Réflexe</FD>
<FG>Pathologie ORL; Pathologie de l'oreille interne; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Electrophysiologie</FG>
<ED>Vestibular syndrome; Parkinson disease; Nervous system diseases; Dopa; Evoked potential; Reflex</ED>
<EG>ENT disease; Internal ear disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Electrophysiology</EG>
<SD>Vestibular síndrome; Parkinson enfermedad; Sistema nervioso patología; Dopa; Potencial evocado; Reflejo</SD>
<LO>INIST-20953.354000502011860140</LO>
<ID>12-0369636</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease

Differential Effect of Dopa and Subthalamic Stimulation on Vestibular Activity in Parkinson's Disease

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